STRINGSTRING
metB metB cysB cysB sufS sufS ynjE ynjE wcaB wcaB cysZ cysZ cysK cysK cysM cysM sseA sseA cysI cysI cysJ cysJ csdA csdA ygdK ygdK metC metC yhaM yhaM cysE cysE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
metBCystathionine gamma-synthase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (386 aa)
cysBDNA-binding transcriptional dual regulator, O-acetyl-L-serine-binding; Function experimentally demonstrated in the studied species; regulator; Belongs to the LysR transcriptional regulatory family. (324 aa)
sufSSelenocysteine lyase, PLP-dependent; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)
ynjEPutative exported thiosulfate sulfur transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (435 aa)
wcaBPutative acyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the transferase hexapeptide repeat family. (162 aa)
cysZPutative inner membrane protein; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (253 aa)
cysKCysteine synthase A, O-acetylserine sulfhydrolase A subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa)
cysMCysteine synthase B (O-acetylserine sulfhydrolase B); Function experimentally demonstrated in the studied species; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa)
sseA3-mercaptopyruvate sulfurtransferase; Function experimentally demonstrated in the studied species; enzyme. (281 aa)
cysISulfite reductase, beta subunit, NAD(P)-binding, heme-binding; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa)
cysJSulfite reductase, alpha subunit, flavoprotein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. (599 aa)
csdACysteine sulfinate desulfinase; Function experimentally demonstrated in the studied species; enzyme. (401 aa)
ygdKPutative Fe-S metabolism protein (sufE-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (147 aa)
metCCystathionine beta-lyase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (395 aa)
yhaMConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0597 family. (436 aa)
cysESerine acetyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the transferase hexapeptide repeat family. (273 aa)
Your Current Organism:
Escherichia coli UMN026
NCBI taxonomy Id: 585056
Other names: E. coli UMN026
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