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| | yjgB | Putative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (339 aa) |
| | mtnB | Methyl-thioribulose-1-phosphate dehydratase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (213 aa) |
| | yjiA | Putative GTPase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (318 aa) |
| | hpaD | 3,4-dihydroxyphenylacetate 2,3-dioxygenase (Homoprotocatechuate 2,3-dioxygenase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (283 aa) |
| | yjjN | Putative oxidoreductase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (340 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa) |
| | yehQ | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (666 aa) |
| | dnaJ | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] (376 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (938 aa) |
| | fixX | Putative 4Fe-4S ferredoxin; Could be a 3Fe-4S cluster-containing protein. (95 aa) |
| | pdxA | 4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa) |
| | araD | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). (231 aa) |
| | araA | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (500 aa) |
| | cueO | Multicopper oxidase (laccase); Function experimentally demonstrated in the studied species; enzyme. (516 aa) |
| | can | Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (220 aa) |
| | yadB | glutamyl-Q tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (308 aa) |
| | dksA | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. (151 aa) |
| | yadR | Putative chaperone involved in Fe-S cluster assembly and activation; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa) |
| | map | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (264 aa) |
| | rnhB | Ribonuclease HII, degrades RNA of DNA-RNA hybrids; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (198 aa) |
| | gmhB | D,D-heptose 1,7-bisphosphate phosphatase; Function experimentally demonstrated in the studied species; enzyme. (190 aa) |
| | lpcA | D-sedoheptulose 7-phosphate isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (192 aa) |
| | yagR | Putative oxidoreductase with molybdenum-binding domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (732 aa) |
| | yahK | Putative oxidoreductase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (349 aa) |
| | cynT | Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (219 aa) |
| | mhpB | 2,3-dihydroxyphenylpropionate 1,2-dioxygenase; Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6- ketononatrienedioate, respectively; Belongs to the LigB/MhpB extradiol dioxygenase family. (314 aa) |
| | mhpD | 2-keto-4-pentenoate hydratase; Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid. Belongs to the hydratase/decarboxylase family. MhpD subfamily. (269 aa) |
| | mhpE | 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase, class I; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (337 aa) |
| | frmA | Alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa) |
| | nrdR | Transcriptional repressor of nrd genes; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (149 aa) |
| | ribD | Fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa) |
| | cyoA | Cytochrome o ubiquinol oxidase subunit II; Function experimentally demonstrated in the studied species; carrier. (315 aa) |
| | clpX | ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa) |
| | queC | Queuosine biosynthesis protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa) |
| | cueR | DNA-binding transcriptional activator of copper-responsive regulon genes; Function experimentally demonstrated in the studied species; regulator. (135 aa) |
| | allB | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (453 aa) |
| | allC | Allantoate amidohydrolase; Function experimentally demonstrated in the studied species; enzyme. (411 aa) |
| | lpxH | UDP-2,3-diacylglucosamine pyrophosphatase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa) |
| | cysS | cysteinyl-tRNA synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. (461 aa) |
| | CAR11794.1 | Conserved hypothetical protein from bacteriophage origin; Homologs of previously reported genes of unknown function; extrachromosomal origin. (72 aa) |
| | fes | Enterobactin/ferric enterobactin esterase; Function experimentally demonstrated in the studied species; enzyme. (374 aa) |
| | ybeY | Putative metal-dependent hydrolase; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (155 aa) |
| | nei | Endonuclease VIII; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (263 aa) |
| | galT | Galactose-1-phosphate uridylyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (348 aa) |
| | modE | DNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator. (262 aa) |
| | yfdR | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; extrachromosomal origin. (178 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (346 aa) |
| | ybiI | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (88 aa) |
| | ybiX | Conserved hypothetical protein with PKHD hydroxylase domain; Homologs of previously reported genes of unknown function. (225 aa) |
| | dps | Fe-binding and storage protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and cop [...] (167 aa) |
| | mntR | DNA-binding transcriptional regulator of mntH; Function experimentally demonstrated in the studied species; regulator. (155 aa) |
| | rumB | 23S rRNA m(5)U747 methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily. (375 aa) |
| | dmsA | Dimethyl sulfoxide reductase, anaerobic, subunit A; Function experimentally demonstrated in the studied species; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (814 aa) |
| | pepN | Function experimentally demonstrated in the studied species; enzyme. (870 aa) |
| | ycbX | Putative 2Fe-2S cluster-containing protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (369 aa) |
| | yccR | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (209 aa) |
| | hyaB | Hydrogenase 1, large subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (597 aa) |
| | hyaC | Hydrogenase 1, b-type cytochrome subunit; Function experimentally demonstrated in the studied species; carrier. (235 aa) |
| | hyaF | Protein involved in nickel incorporation into hydrogenase-1 proteins; Function experimentally demonstrated in the studied species; factor. (285 aa) |
| | torC | Trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit; Function experimentally demonstrated in the studied species; carrier; Belongs to the TorC/TorY family. (390 aa) |
| | torA | Trimethylamine N-oxide (TMAO) reductase I, catalytic subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (848 aa) |
| | ycdX | Putative PHP hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the PHP family. (245 aa) |
| | pyrC | Dihydro-orotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) |
| | rne | Fused ribonucleaseE: endoribonuclease; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1061 aa) |
| | ycfX | N-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (303 aa) |
| | cobB | Deacetylase of acetyl-CoA synthetase, NAD-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the sirtuin family. Class III subfamily. (273 aa) |
| | pepT | Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. (408 aa) |
| | ycfD | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (373 aa) |
| | CAR12593.1 | Conserved hypothetical protein from bacteriophage origin; Homologs of previously reported genes of unknown function; extrachromosomal origin. (72 aa) |
| | tdk | Thymidine kinase/deoxyuridine kinase; Function experimentally demonstrated in the studied species; enzyme. (205 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. (196 aa) |
| | yciM | Conserved hypothetical protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (389 aa) |
| | mpaA | Murein peptide amidase A; Function experimentally demonstrated in the studied species; enzyme. (262 aa) |
| | ydbK | Putative 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (1174 aa) |
| | adhP | Alcohol dehydrogenase, 1-propanol preferring; Function experimentally demonstrated in the studied species; carrier. (336 aa) |
| | ddpX | D-ala-D-ala dipeptidase, Zn-dependent; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. (193 aa) |
| | ydeP | Putative oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa) |
| | rspB | Putative oxidoreductase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (339 aa) |
| | ynfE | Oxidoreductase subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (808 aa) |
| | ynfF | Oxidoreductase subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (807 aa) |
| | manA | Mannose-6-phosphate isomerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannose-6-phosphate isomerase type 1 family. (391 aa) |
| | add | Adenosine deaminase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa) |
| | ydiT | Putative 4Fe-4S ferredoxin-type oxidoreductase subunit; Could be a 3Fe-4S cluster-containing protein. (97 aa) |
| | astE | Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (322 aa) |
| | ydjI | Putative aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (278 aa) |
| | ydjJ | Putative iditol dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (347 aa) |
| | ydjL | Putative oxidoreductase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (358 aa) |
| | msrB | Methionine sulfoxide reductase B; Function experimentally demonstrated in the studied species; enzyme; Belongs to the MsrB Met sulfoxide reductase family. (137 aa) |
| | yeaW | Fragment of putative transporter (partial); Converts carnitine to trimethylamine and malic semialdehyde. (374 aa) |
| | yeaB | Putative NUDIX hydrolase; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. PCD1 subfamily. (192 aa) |
| | htpX | Membrane-associated Zn-dependent endopeptidase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase M48B family. (293 aa) |
| | yebZ | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (290 aa) |
| | yobA | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (124 aa) |
| | torY | TMAO reductase III (TorYZ), cytochrome c-type subunit; Function experimentally demonstrated in the studied species; carrier; Belongs to the TorC/TorY family. (366 aa) |
| | cutC | Copper homeostasis protein; Participates in the control of copper homeostasis. (248 aa) |
| | flhC | DNA-binding transcriptional dual regulator with FlhD; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (192 aa) |
| | yecI | Putative ferritin-like protein; Iron-storage protein. (167 aa) |
| | ftn | Ferritin iron storage protein (cytoplasmic); Iron-storage protein. (165 aa) |
| | yecA | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0149 family. (221 aa) |
| | hchA | Hsp31 molecular chaperone; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), [...] (283 aa) |
| | yodA | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; 12480884, 12909634, 9579078. (216 aa) |
| | CAR13471.1 | Putative lambdoid prophage protein from the DksA/TraR family with a zinc finger; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; extrachromosomal origin. (69 aa) |
| | hisD | Bifunctional histidinal dehydrogenase and histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | gatD | Galactitol-1-phosphate dehydrogenase, Zn-dependent and NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme. (346 aa) |
| | gatY | D-tagatose 1,6-bisphosphate aldolase 2, catalytic subunit; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol. (284 aa) |
| | yohN | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (172 aa) |
| | yehR | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; lipoprotein. (153 aa) |
| | cdd | Cytidine/deoxycytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa) |
| | folE | GTP cyclohydrolase I; Function experimentally demonstrated in the studied species; enzyme. (222 aa) |
| | nfo | Endonuclease IV with intrinsic 3'-5' exonuclease activity; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (285 aa) |
| | yeiR | Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (328 aa) |
| | napA | Nitrate reductase, periplasmic, large subunit; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa) |
| | ada | Fused DNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator. (354 aa) |
| | menD | Bifunctional 2-oxoglutarate decarboxylase and SHCHC synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (556 aa) |
| | elaC | Binuclear zinc phosphodiesterase; Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities. (305 aa) |
| | nuoI | NADH:ubiquinone oxidoreductase, chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (180 aa) |
| | nuoB | NADH:ubiquinone oxidoreductase, chain B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (220 aa) |
| | accD | acetyl-CoA carboxylase, beta (carboxyltranferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (304 aa) |
| | ypdF | Xaa-Pro and Met-Xaa peptidase; Function experimentally demonstrated in the studied species; enzyme. (361 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (471 aa) |
| | pdxK | Pyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. (283 aa) |
| | hemF | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (299 aa) |
| | dapE | N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | hyfG | Hydrogenase 4, subunit; Function experimentally demonstrated in the studied species; carrier. (555 aa) |
| | yfgC | Putative peptidase; Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state. (487 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (372 aa) |
| | pepB | Aminopeptidase B; Probably plays an important role in intracellular peptide degradation. (427 aa) |
| | yfhJ | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; putative factor. (66 aa) |
| | iscA | FeS cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. (107 aa) |
| | iscU | Scaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa) |
| | iscR | DNA-binding transcriptional repressor; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. (162 aa) |
| | hcaE | 3-phenylpropionate dioxygenase, large (alpha) subunit; Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively; Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. (453 aa) |
| | yphC | Putative oxidoreductase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (353 aa) |
| | tadA | tRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (178 aa) |
| | CAR14122.1 | Conserved hypothetical protein from bacteriophage origin; Homologs of previously reported genes of unknown function; extrachromosomal origin. (689 aa) |
| | ygaT | Conserved hypothetical protein; Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (325 aa) |
| | luxS | S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. (876 aa) |
| | norV | Flavorubredoxin oxidoreductase; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. (479 aa) |
| | hypF | Carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (770 aa) |
| | hycE | Hydrogenase 3, large subunit; Function experimentally demonstrated in the studied species; enzyme. (569 aa) |
| | hypA | Protein involved in nickel insertion into hydrogenases 3; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (116 aa) |
| | hypB | GTP hydrolase involved in nickel liganding into hydrogenases; Function experimentally demonstrated in the studied species; enzyme. (290 aa) |
| | hypC | Protein required for maturation of hydrogenases 1 and 3; Function experimentally demonstrated in the studied species; factor. (90 aa) |
| | CAR14223.1 | Putative molybdenum-pterin-binding-protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (155 aa) |
| | CAR14254.1 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (522 aa) |
| | ygcO | Putative 4Fe-4S cluster-containing protein; Could be a 3Fe-4S cluster-containing protein. (86 aa) |
| | rumA | 23S rRNA (uracil-5)-methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (433 aa) |
| | fucA | L-fuculose-1-phosphate aldolase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (215 aa) |
| | fucI | L-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose. (591 aa) |
| | kduI | 5-keto 4-deoxyuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. (278 aa) |
| | xdhA | Xanthine dehydrogenase, molybdenum binding subunit; Function experimentally demonstrated in the studied species; enzyme. (752 aa) |
| | xdhD | Fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (956 aa) |
| | guaD | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (439 aa) |
| | pepP | Proline aminopeptidase P II; Function experimentally demonstrated in the studied species; enzyme. (441 aa) |
| | fbaA | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | speB | Agmatinase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily. (306 aa) |
| | sprT | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; 8113204; Belongs to the SprT family. (165 aa) |
| | yggX | Protein that protects iron-sulfur proteins against oxidative damage; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. (91 aa) |
| | nanK | N-acetylmannosamine kinase 2; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. (291 aa) |
| | hybG | Hydrogenase 2 accessory protein; Function experimentally demonstrated in the studied species; putative factor. (82 aa) |
| | hybF | Protein involved with the maturation of hydrogenases 1 and 2; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa) |
| | hybE | Hydrogenase 2-specific chaperone; Function experimentally demonstrated in the studied species; factor. (162 aa) |
| | hybC | Hydrogenase 2, large subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa) |
| | ygiQ | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (739 aa) |
| | sufI | Repressor protein for FtsI; Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress; Belongs to the FtsP family. (470 aa) |
| | zupT | Putative dioxygenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (271 aa) |
| | ribB | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (217 aa) |
| | gcp | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (337 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (581 aa) |
| | kbaY | Tagatose 6-phosphate aldolase 1, kbaY subunit; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability. (286 aa) |
| | ftsH | Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (644 aa) |
| | nanK-2 | Putative N-acetylmannosamine kinase; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. (291 aa) |
| | zntR | DNA-binding transcriptional activator in response to Zn(II); Function experimentally demonstrated in the studied species; regulator. (141 aa) |
| | bfr | Bacterioferritin, iron storage and detoxification protein; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. (158 aa) |
| | php | Putative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (292 aa) |
| | feoA | Ferrous iron transporter, protein A; Function experimentally demonstrated in the studied species; transporter. (75 aa) |
| | yhgG | Putative DNA-binding transcriptional regulator; May function as a transcriptional regulator that controls feoABC expression. (78 aa) |
| | gntY | Putative gluconate transport associated protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (191 aa) |
| | nikA | Nickel transporter subunit; Function experimentally demonstrated in the studied species; transporter. (524 aa) |
| | nikD | Nickel transporter subunit; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (254 aa) |
| | nikE | Nickel transporter subunit; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa) |
| | nikR | DNA-binding transcriptional repressor, Ni-binding; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel. (133 aa) |
| | CAR15115.1 | Putative aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (283 aa) |
| | yiaF | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (236 aa) |
| | sgbU | Putative L-xylulose 5-phosphate 3-epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (286 aa) |
| | sgbE | L-ribulose-5-phosphate 4-epimerase; Function experimentally demonstrated in the studied species; enzyme. (231 aa) |
| | gpmI | Phosphoglycero mutase III, cofactor-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
| | tdh | Threonine 3-dehydrogenase, NAD(P)-binding; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa) |
| | mutM | Formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (269 aa) |
| | rfe | UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (367 aa) |
| | cyaY | Frataxin, iron-binding and oxidizing protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (106 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa) |
| | fdhE | Formate dehydrogenase formation protein; Necessary for formate dehydrogenase activity. Belongs to the FdhE family. (309 aa) |
| | rhaA | L-rhamnose isomerase; Function experimentally demonstrated in the studied species; enzyme. (419 aa) |
| | yiiM | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (224 aa) |
| | priA | Primosome factor n' (replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (732 aa) |
| | argE | Acetylornithine deacetylase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase M20A family. ArgE subfamily. (383 aa) |
| | rpoC | RNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1407 aa) |
| | thiH | Thiamin biosynthesis ThiGH complex subunit; Function experimentally demonstrated in the studied species; enzyme. (377 aa) |
| | thiC | Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (631 aa) |
| | nudC | NADH pyrophosphatase; Function experimentally demonstrated in the studied species; enzyme. (257 aa) |
| | zraP | Zn-binding periplasmic protein; Binds zinc. Could be an important component of the zinc- balancing mechanism; Belongs to the ZraP family. (139 aa) |
| | metH | homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa) |
| | qor | Quinone oxidoreductase, NADPH-dependent; Function experimentally demonstrated in the studied species; enzyme. (327 aa) |
| | uvrA | ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (940 aa) |
| | nrfA | Nitrite reductase, formate-dependent, cytochrome; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa) |
| | cutA | Copper binding protein, copper sensitivity; Involved in resistance toward heavy metals. Belongs to the CutA family. (112 aa) |
| | nsrR | DNA-binding transcriptional regulator; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. (141 aa) |
| | ulaG | Putative L-ascorbate 6-phosphate lactonase; Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3- keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions; Belongs to the UlaG family. (354 aa) |
| | ulaF | L-ribulose 5-phosphate 4-epimerase; Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization. (228 aa) |
| | cybC | Soluble cytochrome b562; Function experimentally demonstrated in the studied species; carrier. (128 aa) |
| | pepA | Aminopeptidase A, a cyteinylglycinase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (503 aa) |
