STRINGSTRING
fixB fixB ribF ribF ileS ileS fixA fixA panC panC yadB yadB tilS tilS CAR11479.1 CAR11479.1 thiI thiI queC queC cysS cysS ibrA ibrA uspG uspG citC citC nadD nadD leuS leuS asnB asnB glnS glnS phr phr CAR12069.1 CAR12069.1 ycbC ycbC trmU trmU ydaO ydaO uspF uspF ydcF ydcF tyrS tyrS ydiQ ydiQ ydiR ydiR nadE nadE argS argS yecG yecG metG metG gltX gltX guaA guaA cysD cysD cysH cysH ygcQ ygcQ ygcR ygcR rfaE rfaE argG argG trpS trpS uspA uspA coaD coaD yiiT yiiT valS valS nadR nadR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fixBProtein FixB; Required for anaerobic carnitine reduction. May bring reductant to CaiA. (313 aa)
ribFBifunctional riboflavin kinase and FAD synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the ribF family. (313 aa)
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (938 aa)
fixAPutative electron transfer flavoprotein subunit, ETFP adenine nucleotide-binding domain; Required for anaerobic carnitine reduction. May bring reductant to CaiA. (256 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa)
yadBglutamyl-Q tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (308 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (431 aa)
CAR11479.1Glycerol-3-phosphate cytidylyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (134 aa)
thiISulfurtransferase required for thiamine and 4-thiouridine biosynthesis; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa)
queCQueuosine biosynthesis protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa)
cysScysteinyl-tRNA synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. (461 aa)
ibrAImmunoglobulin-binding regulator; Function of strongly homologous gene; regulator. (406 aa)
uspGUniversal stress protein UP12; Function experimentally demonstrated in the studied species; factor. (142 aa)
citCCitrate lyase synthetase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (352 aa)
nadDNicotinic acid mononucleotide adenylyltransferase, NAD(P)-dependent; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (213 aa)
leuSleucyl-tRNA synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. (860 aa)
asnBAsparagine synthetase B; Function experimentally demonstrated in the studied species; enzyme. (554 aa)
glnSglutamyl-tRNA synthetase; Function experimentally demonstrated in the studied species; enzyme. (554 aa)
phrDeoxyribodipyrimidine photolyase, FAD-binding; Function experimentally demonstrated in the studied species; enzyme; Belongs to the DNA photolyase family. (472 aa)
CAR12069.1Putative phosphoadenosine phosphosulfate reductase from phage origin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; extrachromosomal origin. (292 aa)
ycbCConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (259 aa)
trmUtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. (368 aa)
ydaOPutative C32 tRNA thiolase; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (311 aa)
uspFStress-induced protein, ATP-binding protein; Function experimentally demonstrated in the studied species; factor. (144 aa)
ydcFConserved hypothetical protein; Homologs of previously reported genes of unknown function. (266 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (424 aa)
ydiQPutative electron transfer flavoprotein subunit (etfB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (254 aa)
ydiRPutative electron transfer flavoprotein subunit, FAD-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (312 aa)
nadENAD synthetase, NH3/glutamine-dependent; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa)
argSarginyl-tRNA synthetase; Function experimentally demonstrated in the studied species; enzyme. (577 aa)
yecGUniversal stress protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (142 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (677 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (471 aa)
guaAGMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (525 aa)
cysDSulfate adenylyltransferase, subunit 2; Function experimentally demonstrated in the studied species; enzyme. (302 aa)
cysH3'-phosphoadenosine 5'-phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (244 aa)
ygcQPutative flavoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (286 aa)
ygcRPutative flavoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (259 aa)
rfaEFused heptose 7-phosphate kinase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (477 aa)
argGArgininosuccinate synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (334 aa)
uspAUniversal stress global response regulator; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (144 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
yiiTStress-induced protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (142 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (951 aa)
nadRBifunctional DNA-binding transcriptional repressor and NMN adenylyltransferase; Function experimentally demonstrated in the studied species; regulator. (410 aa)
Your Current Organism:
Escherichia coli UMN026
NCBI taxonomy Id: 585056
Other names: E. coli UMN026
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