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yafV yafV metN metN metI metI metQ metQ ybdH ybdH ybdL ybdL yeeE yeeE yeeD yeeD yedO yedO ydjN ydjN malY malY cysB cysB yciW yciW CAR18579.1 CAR18579.1 cysK cysK cysM cysM cysA cysA cysW cysW cysU cysU cysP cysP sseA sseA cysC cysC cysN cysN cysD cysD cysH cysH cysI cysI cysJ cysJ metF metF metB metB sbp sbp metE metE metR metR metK metK metC metC glpE glpE cysE cysE CAR20303.1 CAR20303.1 nlpA nlpA metA metA metH metH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yafVPutative C-N hydrolase family amidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (256 aa)
metNDL-methionine transporter subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
metIDL-methionine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (217 aa)
metQDL-methionine transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the nlpA lipoprotein family. (271 aa)
ybdHPutative oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (362 aa)
ybdLMethionine aminotransferase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (386 aa)
yeeEConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (352 aa)
yeeDConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the sulfur carrier protein TusA family. (75 aa)
yedOD-cysteine desulfhydrase, PLP-dependent; Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. (328 aa)
ydjNPutative cation-acid symporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (463 aa)
malYBifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon; Function experimentally demonstrated in the studied species; enzyme. (390 aa)
cysBDNA-binding transcriptional dual regulator, O-acetyl-L-serine-binding; Function experimentally demonstrated in the studied species; regulator; Belongs to the LysR transcriptional regulatory family. (324 aa)
yciWPutative amidase or amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (375 aa)
CAR18579.1Cystathionine gamma-synthase (CGS) (O-succinylhomoserine (thiol)-lyase). (405 aa)
cysKCysteine synthase A, O-acetylserine sulfhydrolase A subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa)
cysMCysteine synthase B (O-acetylserine sulfhydrolase B); Function experimentally demonstrated in the studied species; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa)
cysASulfate/thiosulfate transporter subunit; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (365 aa)
cysWSulfate/thiosulfate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (291 aa)
cysUSulfate/thiosulfate transporter subunit; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (277 aa)
cysPThiosulfate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (338 aa)
sseA3-mercaptopyruvate sulfurtransferase; Function experimentally demonstrated in the studied species; enzyme. (281 aa)
cysCAdenosine 5'-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa)
cysNSulfate adenylyltransferase, subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (475 aa)
cysDSulfate adenylyltransferase, subunit 2; Function experimentally demonstrated in the studied species; enzyme. (302 aa)
cysH3'-phosphoadenosine 5'-phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (244 aa)
cysISulfite reductase, beta subunit, NAD(P)-binding, heme-binding; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa)
cysJSulfite reductase, alpha subunit, flavoprotein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. (599 aa)
metF5,10-methylenetetrahydrofolate reductase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the methylenetetrahydrofolate reductase family. (296 aa)
metBCystathionine gamma-synthase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (386 aa)
sbpSulfate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (329 aa)
metE5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa)
metRDNA-binding transcriptional activator, homocysteine-binding; Function experimentally demonstrated in the studied species; regulator; Belongs to the LysR transcriptional regulatory family. (317 aa)
metKMethionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
metCCystathionine beta-lyase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (395 aa)
glpEThiosulfate:cyanide sulfurtransferase (rhodanese); Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (108 aa)
cysESerine acetyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the transferase hexapeptide repeat family. (273 aa)
CAR20303.1Putative Aspartate transaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (430 aa)
nlpACytoplasmic membrane lipoprotein-28; Function experimentally demonstrated in the studied species; lipoprotein; Belongs to the nlpA lipoprotein family. (272 aa)
metAHomoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa)
metHhomocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
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