STRINGSTRING
phoR phoR phoB phoB nlpE nlpE crcA crcA yedW yedW yedV yedV rstB rstB rstA rstA ydgC ydgC CAR17896.1 CAR17896.1 phoP phoP phoQ phoQ yeiU yeiU ais ais yfbE yfbE yfbF yfbF yfbG yfbG yfbH yfbH arnT arnT yfbW yfbW yfbJ yfbJ pmrD pmrD yfhA yfhA yfhG yfhG yfhK yfhK cpxP cpxP cpxR cpxR cpxA cpxA ygiV ygiV ygiW ygiW qseB qseB qseC qseC arcB arcB envZ envZ ompR ompR rpoH rpoH eptB eptB basS basS basR basR eptA eptA mgtA mgtA rob rob creA creA creB creB creC creC creD creD arcA arcA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
phoRSensory histidine kinase in two-component regulatory system with PhoB; Function experimentally demonstrated in the studied species; regulator. (431 aa)
phoBDNA-binding response regulator in two-component regulatory system with PhoR (or CreC); Function experimentally demonstrated in the studied species; regulator. (229 aa)
nlpELipoprotein involved with copper homeostasis and adhesion; Function experimentally demonstrated in the studied species; lipoprotein. (236 aa)
crcAPalmitoyl transferase for Lipid A; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (186 aa)
yedWDNA-binding response regulator in two-component system with YedV; Function experimentally demonstrated in the studied species; regulator. (223 aa)
yedVSensory kinase in two-component regulatory system with YedW; Member of a two-component regulatory system. (452 aa)
rstBSensory histidine kinase in two-component regulatory system with RstA; Function experimentally demonstrated in the studied species; regulator. (433 aa)
rstADNA-binding response regulator in two-component regulatory system with RstB; Function experimentally demonstrated in the studied species; regulator. (242 aa)
ydgCConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (111 aa)
CAR17896.1Conserved hypothetical protein; Connects the signal transduction between the two-component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions; Belongs to the SafA family. (65 aa)
phoPDNA-binding response regulator in two-component regulatory system with PhoQ; Function experimentally demonstrated in the studied species; regulator. (223 aa)
phoQSensory histidine kinase in two-compoent regulatory system with PhoP; Function experimentally demonstrated in the studied species; regulator. (486 aa)
yeiUUndecaprenyl pyrophosphate phosphatase; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (237 aa)
aisConserved hypothetical protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. (200 aa)
yfbEUridine 5'-(beta-1-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase, PLP-dependent; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (385 aa)
yfbFUndecaprenyl phosphate-L-Ara4FN transferase; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (322 aa)
yfbGFused UDP-L-Ara4N formyltransferase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa)
yfbHConserved hypothetical protein; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (296 aa)
arnT4-amino-4-deoxy-L-arabinose transferase; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (550 aa)
yfbWConserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (111 aa)
yfbJConserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (128 aa)
pmrDPolymyxin resistance protein B; Function experimentally demonstrated in the studied species; putative transporter. (88 aa)
yfhAPutative DNA-binding response regulator in two-component system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (444 aa)
yfhGConserved hypothetical protein; Homologs of previously reported genes of unknown function. (237 aa)
yfhKPutative sensory kinase in two-component system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (475 aa)
cpxPPeriplasmic protein combats stress; Function experimentally demonstrated in the studied species; regulator. (166 aa)
cpxRDNA-binding response regulator in two-component regulatory system with CpxA; Function experimentally demonstrated in the studied species; regulator. (232 aa)
cpxASensory histidine kinase in two-component regulatory system with CpxR; Function experimentally demonstrated in the studied species; regulator. (457 aa)
ygiVPutative transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (160 aa)
ygiWConserved hypothetical protein; Homologs of previously reported genes of unknown function. (130 aa)
qseBDNA-binding response regulator in two-component regulatory system with QseC; Function experimentally demonstrated in the studied species; regulator. (219 aa)
qseCSensory histidine kinase in two-component regulatory system with QseB; Function experimentally demonstrated in the studied species; regulator. (449 aa)
arcBHybrid sensory histidine kinase in two-component regulatory system with ArcA; Function experimentally demonstrated in the studied species; regulator. (778 aa)
envZSensory histidine kinase in two-component regulatory system with OmpR; Function experimentally demonstrated in the studied species; regulator. (450 aa)
ompRDNA-binding response regulator in two-component regulatory system with EnvZ; Function experimentally demonstrated in the studied species; regulator. (239 aa)
rpoHRNA polymerase, sigma 32 (sigma H) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (284 aa)
eptBPutative metal dependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (563 aa)
basSSensory histidine kinase in two-component regulatory system with BasR; Function experimentally demonstrated in the studied species; regulator. (366 aa)
basRDNA-binding response regulator in two-component regulatory system with BasS; Function experimentally demonstrated in the studied species; regulator. (222 aa)
eptAPutative metal dependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (547 aa)
mgtAMagnesium transporter; Function experimentally demonstrated in the studied species; transporter. (898 aa)
robDNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (289 aa)
creAConserved hypothetical protein; Homologs of previously reported genes of unknown function; 8449900. (157 aa)
creBDNA-binding response regulator in two-component regulatory system with CreC; Function experimentally demonstrated in the studied species; regulator. (229 aa)
creCTwo-component system, OmpR family, sensor histidine kinase CreC; Function experimentally demonstrated in the studied species; regulator. (474 aa)
creDInner membrane protein; Function experimentally demonstrated in the studied species; membrane component. (450 aa)
arcADNA-binding response regulator in two-component regulatory system with ArcB or CpxA; Function experimentally demonstrated in the studied species; regulator. (238 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
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