(6 nodes) Mixed, incl. NADP+ binding, and Nucleotidyl transferase network (Escherichia coli IAI39)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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experimentally determined

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protein homology

Your Input:
	gmd	GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (373 aa)
	fcl	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
	nudD	GDP-mannose mannosyl hydrolase; Hydrolyzes GDP-mannose; Belongs to the Nudix hydrolase family. (159 aa)
	wcaI	Putative glycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (407 aa)
	cpsB	Mannose-1-phosphate guanyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family. (478 aa)
	wcaJ	Putative UDP-sugar lipid carrier transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (464 aa)

Your Current Organism:

Escherichia coli IAI39

NCBI taxonomy Id: 585057
Other names: E. coli IAI39

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cpsB	fcl	ECIAI39_0966	ECIAI39_0963	Mannose-1-phosphate guanyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family.	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.	0.882
cpsB	gmd	ECIAI39_0966	ECIAI39_0962	Mannose-1-phosphate guanyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family.	GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.	0.991
cpsB	nudD	ECIAI39_0966	ECIAI39_0964	Mannose-1-phosphate guanyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family.	GDP-mannose mannosyl hydrolase; Hydrolyzes GDP-mannose; Belongs to the Nudix hydrolase family.	0.847
cpsB	wcaI	ECIAI39_0966	ECIAI39_0965	Mannose-1-phosphate guanyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family.	Putative glycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.855
cpsB	wcaJ	ECIAI39_0966	ECIAI39_0968	Mannose-1-phosphate guanyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family.	Putative UDP-sugar lipid carrier transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.993
fcl	cpsB	ECIAI39_0963	ECIAI39_0966	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.	Mannose-1-phosphate guanyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family.	0.882
fcl	gmd	ECIAI39_0963	ECIAI39_0962	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.	GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.	0.999
fcl	nudD	ECIAI39_0963	ECIAI39_0964	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.	GDP-mannose mannosyl hydrolase; Hydrolyzes GDP-mannose; Belongs to the Nudix hydrolase family.	0.991
fcl	wcaI	ECIAI39_0963	ECIAI39_0965	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.	Putative glycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.982
fcl	wcaJ	ECIAI39_0963	ECIAI39_0968	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.	Putative UDP-sugar lipid carrier transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.929
gmd	cpsB	ECIAI39_0962	ECIAI39_0966	GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.	Mannose-1-phosphate guanyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family.	0.991
gmd	fcl	ECIAI39_0962	ECIAI39_0963	GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.	0.999
gmd	nudD	ECIAI39_0962	ECIAI39_0964	GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.	GDP-mannose mannosyl hydrolase; Hydrolyzes GDP-mannose; Belongs to the Nudix hydrolase family.	0.997
gmd	wcaI	ECIAI39_0962	ECIAI39_0965	GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.	Putative glycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.984
gmd	wcaJ	ECIAI39_0962	ECIAI39_0968	GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.	Putative UDP-sugar lipid carrier transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.977
nudD	cpsB	ECIAI39_0964	ECIAI39_0966	GDP-mannose mannosyl hydrolase; Hydrolyzes GDP-mannose; Belongs to the Nudix hydrolase family.	Mannose-1-phosphate guanyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family.	0.847
nudD	fcl	ECIAI39_0964	ECIAI39_0963	GDP-mannose mannosyl hydrolase; Hydrolyzes GDP-mannose; Belongs to the Nudix hydrolase family.	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.	0.991
nudD	gmd	ECIAI39_0964	ECIAI39_0962	GDP-mannose mannosyl hydrolase; Hydrolyzes GDP-mannose; Belongs to the Nudix hydrolase family.	GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.	0.997
nudD	wcaI	ECIAI39_0964	ECIAI39_0965	GDP-mannose mannosyl hydrolase; Hydrolyzes GDP-mannose; Belongs to the Nudix hydrolase family.	Putative glycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.997
nudD	wcaJ	ECIAI39_0964	ECIAI39_0968	GDP-mannose mannosyl hydrolase; Hydrolyzes GDP-mannose; Belongs to the Nudix hydrolase family.	Putative UDP-sugar lipid carrier transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.853