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cueO cueO acrA acrA cueR cueR cusS cusS cusR cusR cusC cusC cusF cusF cusB cusB cusA cusA pheP pheP cmr cmr CAR17071.1 CAR17071.1 baeR baeR baeS baeS mdtD mdtD mdtC mdtC mdtB mdtB mdtA mdtA yebE yebE spy spy mdtK mdtK CAR17764.1 CAR17764.1 CAR17769.1 CAR17769.1 CAR17770.1 CAR17770.1 ycfS ycfS mdtH mdtH mdtG mdtG macB macB macA macA acrD acrD mprA mprA emrA emrA emrB emrB tolC tolC acrE acrE yhdV yhdV mdtE mdtE mdtF mdtF emrD emrD yjcP yjcP yjcQ yjcQ yjcR yjcR yjeJ yjeJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cueOMulticopper oxidase (laccase); Function experimentally demonstrated in the studied species; enzyme. (516 aa)
acrAMultidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (397 aa)
cueRDNA-binding transcriptional activator of copper-responsive regulon genes; Function experimentally demonstrated in the studied species; regulator. (137 aa)
cusSFragment of bacteriophage N4 receptor, inner membrane subunit (part 1); Member of a two-component regulatory system. (480 aa)
cusRDNA-binding response regulator in two-component regulatory system with CusS; Function experimentally demonstrated in the studied species; regulator. (227 aa)
cusCCopper/silver efflux system, outer membrane component; Function experimentally demonstrated in the studied species; transporter. (460 aa)
cusFPeriplasmic copper-binding protein; Function of strongly homologous gene; factor. (110 aa)
cusBCopper/silver efflux system, membrane fusion protein; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (407 aa)
cusACopper/silver efflux system, membrane component; Function experimentally demonstrated in the studied species; transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1047 aa)
phePPhenylalanine transporter; Function experimentally demonstrated in the studied species; transporter. (458 aa)
cmrMultidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter. (410 aa)
CAR17071.1Conserved hypothetical protein; Doubtful CDS. (64 aa)
baeRDNA-binding response regulator in two-component regulatory system with BaeS; Function experimentally demonstrated in the studied species; regulator. (240 aa)
baeSSensory histidine kinase in two-component regulatory system with BaeR; Function experimentally demonstrated in the studied species; regulator. (467 aa)
mdtDMultidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter. (471 aa)
mdtCMultidrug efflux system, subunit C; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily. (1025 aa)
mdtBMultidrug efflux system, subunit B; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. (1040 aa)
mdtAMultidrug efflux system, subunit A; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (415 aa)
yebEConserved hypothetical protein; Homologs of previously reported genes of unknown function. (219 aa)
spyEnvelope stress induced periplasmic protein; Function experimentally demonstrated in the studied species; cell process. (161 aa)
mdtKMultidrug efflux system transporter; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. (457 aa)
CAR17764.1Putative efflux protein, membrane fusion (MFP) family precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (383 aa)
CAR17769.1Putative efflux pump (Putative multidrug-efflux transport protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (1035 aa)
CAR17770.1Putative outer membrane channel protein of an efflux system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (457 aa)
ycfSConserved hypothetical protein; Homologs of previously reported genes of unknown function. (320 aa)
mdtHPutative metabolite efflux permease; Confers resistance to norfloxacin and enoxacin. Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily. (402 aa)
mdtGPutative metabolite efflux transporter; Confers resistance to fosfomycin and deoxycholate. Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. (408 aa)
macBFused macrolide transporter subunits of ABC superfamily: ATP-binding component; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (648 aa)
macAMacrolide transporter subunit, membrane fusion protein (MFP) component; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (371 aa)
acrDAminoglycoside/multidrug efflux system; Function experimentally demonstrated in the studied species; transporter. (1037 aa)
mprADNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; Function experimentally demonstrated in the studied species; regulator. (176 aa)
emrAMultidrug efflux system; Function experimentally demonstrated in the studied species; transporter. (390 aa)
emrBMultidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter; Belongs to the major facilitator superfamily. (512 aa)
tolCTransport channel; Function experimentally demonstrated in the studied species; transporter. (493 aa)
acrECytoplasmic membrane lipoprotein; Function experimentally demonstrated in the studied species; lipoprotein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (385 aa)
yhdVFragment of multidrug efflux system protein (part 2); Gene remnant; transporter. (73 aa)
mdtEMultidrug resistance efflux transporter; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (385 aa)
mdtFMultidrug transporter, RpoS-dependent; Function experimentally demonstrated in the studied species; transporter. (1037 aa)
emrDMultidrug efflux system protein; Function experimentally demonstrated in the studied species; transporter. (394 aa)
yjcPOuter membrane factor of efflux pump; Function of strongly homologous gene; putative transporter. (488 aa)
yjcQMultidrug efflux system component; Function of strongly homologous gene; transporter. (683 aa)
yjcRMembrane fusion protein of efflux pump; Function of strongly homologous gene; transporter. (343 aa)
yjeJConserved hypothetical protein; Homologs of previously reported genes of unknown function. (289 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
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