(21 nodes) Mixed, incl. Cellular iron ion homeostasis, and ABC transporter, permease protein, BtuC-like network (Escherichia coli IAI39)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fhuC	Iron-hydroxamate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (265 aa)
	fhuD	Iron-hydroxamate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (296 aa)
	fhuB	Fused iron-hydroxamate transporter subunits of ABC superfamily: membrane components; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (660 aa)
	btuF	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. (266 aa)
	btuC	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane. (326 aa)
	btuD	Vitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. (249 aa)
	chuS	Heme oxygenase; Function experimentally demonstrated in the studied species; enzyme. (342 aa)
	chuA	Outer membrane hemin receptor; Function experimentally demonstrated in the studied species; transporter. (660 aa)
	chuT	Putative periplasmic binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (330 aa)
	CAR20116.1	Putative oxygen independent coproporphyrinogen III oxidase (chuW-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (445 aa)
	CAR20117.1	Conserved hypothetical protein (chuX protein); Homologs of previously reported genes of unknown function. (164 aa)
	CAR20118.1	Conserved hypothetical protein (chuY); Homologs of previously reported genes of unknown function. (207 aa)
	chuU	Putative hemin transport system permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (330 aa)
	chuV	Putative hemin ABC-type transport system ATP-binding protein; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. (266 aa)
	fecE	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (255 aa)
	fecD	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (328 aa)
	fecC	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (332 aa)
	fecB	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (300 aa)
	fecA	Ferric citrate outer membrane transporter; Function experimentally demonstrated in the studied species; transporter. (774 aa)
	fecR	Transmembrane signal transducer for ferric citrate transport; Function experimentally demonstrated in the studied species; regulator. (317 aa)
	fecI	RNA polymerase, sigma 19 factor; Function experimentally demonstrated in the studied species; regulator; Belongs to the sigma-70 factor family. ECF subfamily. (173 aa)

Your Current Organism:

Escherichia coli IAI39

NCBI taxonomy Id: 585057
Other names: E. coli IAI39

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAR20116.1	CAR20117.1	ECIAI39_4005	ECIAI39_4006	Putative oxygen independent coproporphyrinogen III oxidase (chuW-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Conserved hypothetical protein (chuX protein); Homologs of previously reported genes of unknown function.	0.993
CAR20116.1	CAR20118.1	ECIAI39_4005	ECIAI39_4007	Putative oxygen independent coproporphyrinogen III oxidase (chuW-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Conserved hypothetical protein (chuY); Homologs of previously reported genes of unknown function.	0.968
CAR20116.1	chuS	ECIAI39_4005	ECIAI39_4001	Putative oxygen independent coproporphyrinogen III oxidase (chuW-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Heme oxygenase; Function experimentally demonstrated in the studied species; enzyme.	0.639
CAR20116.1	chuT	ECIAI39_4005	ECIAI39_4004	Putative oxygen independent coproporphyrinogen III oxidase (chuW-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Putative periplasmic binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.757
CAR20116.1	chuU	ECIAI39_4005	ECIAI39_4008	Putative oxygen independent coproporphyrinogen III oxidase (chuW-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Putative hemin transport system permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.631
CAR20116.1	chuV	ECIAI39_4005	ECIAI39_4009	Putative oxygen independent coproporphyrinogen III oxidase (chuW-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Putative hemin ABC-type transport system ATP-binding protein; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.	0.631
CAR20117.1	CAR20116.1	ECIAI39_4006	ECIAI39_4005	Conserved hypothetical protein (chuX protein); Homologs of previously reported genes of unknown function.	Putative oxygen independent coproporphyrinogen III oxidase (chuW-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.993
CAR20117.1	CAR20118.1	ECIAI39_4006	ECIAI39_4007	Conserved hypothetical protein (chuX protein); Homologs of previously reported genes of unknown function.	Conserved hypothetical protein (chuY); Homologs of previously reported genes of unknown function.	0.989
CAR20117.1	chuS	ECIAI39_4006	ECIAI39_4001	Conserved hypothetical protein (chuX protein); Homologs of previously reported genes of unknown function.	Heme oxygenase; Function experimentally demonstrated in the studied species; enzyme.	0.721
CAR20117.1	chuT	ECIAI39_4006	ECIAI39_4004	Conserved hypothetical protein (chuX protein); Homologs of previously reported genes of unknown function.	Putative periplasmic binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.840
CAR20117.1	chuU	ECIAI39_4006	ECIAI39_4008	Conserved hypothetical protein (chuX protein); Homologs of previously reported genes of unknown function.	Putative hemin transport system permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.655
CAR20117.1	chuV	ECIAI39_4006	ECIAI39_4009	Conserved hypothetical protein (chuX protein); Homologs of previously reported genes of unknown function.	Putative hemin ABC-type transport system ATP-binding protein; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.	0.727
CAR20118.1	CAR20116.1	ECIAI39_4007	ECIAI39_4005	Conserved hypothetical protein (chuY); Homologs of previously reported genes of unknown function.	Putative oxygen independent coproporphyrinogen III oxidase (chuW-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.968
CAR20118.1	CAR20117.1	ECIAI39_4007	ECIAI39_4006	Conserved hypothetical protein (chuY); Homologs of previously reported genes of unknown function.	Conserved hypothetical protein (chuX protein); Homologs of previously reported genes of unknown function.	0.989
CAR20118.1	chuT	ECIAI39_4007	ECIAI39_4004	Conserved hypothetical protein (chuY); Homologs of previously reported genes of unknown function.	Putative periplasmic binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.740
CAR20118.1	chuU	ECIAI39_4007	ECIAI39_4008	Conserved hypothetical protein (chuY); Homologs of previously reported genes of unknown function.	Putative hemin transport system permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.643
CAR20118.1	chuV	ECIAI39_4007	ECIAI39_4009	Conserved hypothetical protein (chuY); Homologs of previously reported genes of unknown function.	Putative hemin ABC-type transport system ATP-binding protein; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.	0.632
btuC	btuD	ECIAI39_1342	ECIAI39_1344	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.	Vitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.	0.999
btuC	btuF	ECIAI39_1342	ECIAI39_0162	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.	0.999
btuC	chuT	ECIAI39_1342	ECIAI39_4004	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.	Putative periplasmic binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.763