(13 nodes) Cellular iron ion homeostasis, and Cobalamin transport network (Escherichia coli IAI39)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fhuC	Iron-hydroxamate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (265 aa)
	fhuD	Iron-hydroxamate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (296 aa)
	fhuB	Fused iron-hydroxamate transporter subunits of ABC superfamily: membrane components; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (660 aa)
	btuF	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. (266 aa)
	btuC	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane. (326 aa)
	btuD	Vitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. (249 aa)
	fecE	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (255 aa)
	fecD	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (328 aa)
	fecC	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (332 aa)
	fecB	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter. (300 aa)
	fecA	Ferric citrate outer membrane transporter; Function experimentally demonstrated in the studied species; transporter. (774 aa)
	fecR	Transmembrane signal transducer for ferric citrate transport; Function experimentally demonstrated in the studied species; regulator. (317 aa)
	fecI	RNA polymerase, sigma 19 factor; Function experimentally demonstrated in the studied species; regulator; Belongs to the sigma-70 factor family. ECF subfamily. (173 aa)

Your Current Organism:

Escherichia coli IAI39

NCBI taxonomy Id: 585057
Other names: E. coli IAI39

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
btuC	btuD	ECIAI39_1342	ECIAI39_1344	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.	Vitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.	0.999
btuC	btuF	ECIAI39_1342	ECIAI39_0162	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.	0.999
btuC	fecE	ECIAI39_1342	ECIAI39_4765	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter.	0.775
btuC	fhuC	ECIAI39_1342	ECIAI39_0155	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.	Iron-hydroxamate transporter subunit; Function experimentally demonstrated in the studied species; transporter.	0.773
btuC	fhuD	ECIAI39_1342	ECIAI39_0156	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.	Iron-hydroxamate transporter subunit; Function experimentally demonstrated in the studied species; transporter.	0.617
btuD	btuC	ECIAI39_1344	ECIAI39_1342	Vitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.	0.999
btuD	btuF	ECIAI39_1344	ECIAI39_0162	Vitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.	0.997
btuD	fecC	ECIAI39_1344	ECIAI39_4767	Vitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.495
btuD	fecD	ECIAI39_1344	ECIAI39_4766	Vitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.493
btuD	fhuB	ECIAI39_1344	ECIAI39_0157	Vitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.	Fused iron-hydroxamate transporter subunits of ABC superfamily: membrane components; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.490
btuF	btuC	ECIAI39_0162	ECIAI39_1342	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.	Vitamin B12 transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.	0.999
btuF	btuD	ECIAI39_0162	ECIAI39_1344	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.	Vitamin B12 transporter subunit : ATP-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.	0.997
btuF	fecC	ECIAI39_0162	ECIAI39_4767	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.806
btuF	fecD	ECIAI39_0162	ECIAI39_4766	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.811
btuF	fecE	ECIAI39_0162	ECIAI39_4765	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter.	0.692
btuF	fhuB	ECIAI39_0162	ECIAI39_0157	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.	Fused iron-hydroxamate transporter subunits of ABC superfamily: membrane components; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.696
btuF	fhuC	ECIAI39_0162	ECIAI39_0155	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.	Iron-hydroxamate transporter subunit; Function experimentally demonstrated in the studied species; transporter.	0.687
btuF	fhuD	ECIAI39_0162	ECIAI39_0156	Vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.	Iron-hydroxamate transporter subunit; Function experimentally demonstrated in the studied species; transporter.	0.639
fecA	fecB	ECIAI39_4769	ECIAI39_4768	Ferric citrate outer membrane transporter; Function experimentally demonstrated in the studied species; transporter.	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter.	0.994
fecA	fecC	ECIAI39_4769	ECIAI39_4767	Ferric citrate outer membrane transporter; Function experimentally demonstrated in the studied species; transporter.	Iron-dicitrate transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.989