STRINGSTRING
speD speD speE speE ldcC ldcC yahL yahL CAR16785.1 CAR16785.1 CAR16786.1 CAR16786.1 potE potE speF speF CAR16789.1 CAR16789.1 ybjC ybjC rimK rimK ybjN ybjN CAR16970.1 CAR16970.1 potF potF potG potG potH potH potI potI ybjO ybjO rumB rumB speG speG ynfB ynfB ynfA ynfA ymjA ymjA puuP puuP puuA puuA puuD puuD puuR puuR puuC puuC puuB puuB puuE puuE yneI yneI potA potA potB potB potC potC potD potD ymfA ymfA ycfZ ycfZ ygaT ygaT ygaF ygaF gabD gabD gabT gabT gabP gabP csiR csiR speB speB speA speA yqgB yqgB speC speC ygjG ygjG adiA adiA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
speDS-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (264 aa)
speESpermidine synthase (putrescine aminopropyltransferase); Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (288 aa)
ldcCLysine decarboxylase 2, constitutive; Function experimentally demonstrated in the studied species; enzyme. (713 aa)
yahLConserved hypothetical protein; Homologs of previously reported genes of unknown function. (271 aa)
CAR16785.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (252 aa)
CAR16786.1Hypothetical protein; Doubtful CDS. (49 aa)
potEPutrescine/proton symporter: putrescine/ornithine antiporter; Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (439 aa)
speFOrnithine decarboxylase isozyme, inducible; Function experimentally demonstrated in the studied species; enzyme. (732 aa)
CAR16789.1Hypothetical protein; Doubtful CDS. (85 aa)
ybjCConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (95 aa)
rimKRibosomal protein S6 modification protein; Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH. Belongs to the RimK family. (300 aa)
ybjNConserved hypothetical protein; Homologs of previously reported genes of unknown function. (158 aa)
CAR16970.1Hypothetical protein. (53 aa)
potFPutrescine transporter subunit: periplasmic-binding component of ABC superfamily; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family. (370 aa)
potGPutrescine transporter subunit: ATP-binding component of ABC superfamily; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (377 aa)
potHPutrescine transporter subunit: membrane component of ABC superfamily; Function experimentally demonstrated in the studied species; transporter. (317 aa)
potIPutrescine transporter subunit: membrane component of ABC superfamily; Function experimentally demonstrated in the studied species; transporter. (281 aa)
ybjOConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (162 aa)
rumB23S rRNA m(5)U747 methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily. (375 aa)
speGSpermidine N1-acetyltransferase; Function experimentally demonstrated in the studied species; enzyme. (186 aa)
ynfBConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0482 family. (113 aa)
ynfAConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (108 aa)
ymjAConserved hypothetical protein; Homologs of previously reported genes of unknown function. (81 aa)
puuPPutrescine importer; Function experimentally demonstrated in the studied species; transporter. (461 aa)
puuAgamma-Glu-putrescine synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the glutamine synthetase family. (472 aa)
puuDgamma-Glu-GABA hydrolase; Function experimentally demonstrated in the studied species; enzyme. (254 aa)
puuRDNA-binding transcriptional repressor; Function experimentally demonstrated in the studied species; regulator. (185 aa)
puuCgamma-Glu-gamma-aminobutyraldehyde dehydrogenase, NAD(P)H-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aldehyde dehydrogenase family. (495 aa)
puuBgamma-Glu-putrescine oxidase, FAD/NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme. (426 aa)
puuEGABA aminotransferase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
yneIPutative aldehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (462 aa)
potAPolyamine transporter subunit; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (378 aa)
potBPolyamine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (275 aa)
potCPolyamine transporter subunit; Function experimentally demonstrated in the studied species; transporter. (264 aa)
potDPolyamine transporter subunit; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family. (348 aa)
ymfAConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (153 aa)
ycfZConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (262 aa)
ygaTConserved hypothetical protein; Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (325 aa)
ygaFPutative enzyme; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (422 aa)
gabDSuccinate-semialdehyde dehydrogenase I, NADP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aldehyde dehydrogenase family. (482 aa)
gabT4-aminobutyrate aminotransferase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa)
gabPGamma-aminobutyrate transporter; Function experimentally demonstrated in the studied species; transporter. (466 aa)
csiRDNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator. (220 aa)
speBAgmatinase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily. (306 aa)
speABiosynthetic arginine decarboxylase, PLP-binding; Catalyzes the biosynthesis of agmatine from arginine. (658 aa)
yqgBConserved hypothetical protein; Homologs of previously reported genes of unknown function. (48 aa)
speCOrnithine decarboxylase, constitutive; Function experimentally demonstrated in the studied species; enzyme. (711 aa)
ygjGPutrescine:2-oxoglutaric acid aminotransferase, PLP-dependent; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (468 aa)
adiABiodegradative arginine decarboxylase; Function experimentally demonstrated in the studied species; enzyme. (756 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.