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ydfG ydfG thrA thrA pdxA pdxA leuB leuB gcd gcd dxr dxr panE panE ribD ribD frmA frmA betA betA ykgE ykgE ybdH ybdH CAR16807.1 CAR16807.1 CAR16808.1 CAR16808.1 ybiC ybiC yliI yliI dld dld gatD gatD fcl fcl rmlD rmlD gnd gnd ugd ugd hisD hisD zwf zwf yeaU yeaU ydjJ ydjJ chbF chbF CAR17487.1 CAR17487.1 ydiB ydiB hdhA hdhA adhE adhE ldhA ldhA adhP adhP sfcA sfcA uxaB uxaB ydfI ydfI icd-2 icd-2 fabG fabG ycdW ycdW rutE rutE yeiQ yeiQ mqo mqo glpA glpA glpB glpB yfbG yfbG pdxB pdxB yfcX yfcX eutG eutG maeB maeB guaB guaB yphC yphC ygaF ygaF srlD srlD rffD rffD ilvC ilvC gldA gldA metL metL yihU yihU fadB fadB fucO fucO kduD kduD serA serA glcF glcF glcE glcE glcD glcD yghZ yghZ yqhD yqhD dkgA dkgA garR garR mdh mdh aroE aroE glpD glpD tiaE tiaE yiaK yiaK yiaY yiaY mtlD mtlD lldD lldD gpsA gpsA tdh tdh CAR20390.1 CAR20390.1 murB murB CAR20517.1 CAR20517.1 melA melA idnO idnO idnD idnD yjgB yjgB uxuB uxuB
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
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gene co-occurrence
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textmining
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ydfGL-allo-threonine dehydrogenase, NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
thrAFused aspartokinase I; Function experimentally demonstrated in the studied species; enzyme; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa)
pdxA4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
gcdGlucose dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (796 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (398 aa)
panE2-dehydropantoate reductase, NADPH-specific; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (303 aa)
ribDFused diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa)
frmAAlcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
betACholine dehydrogenase, a flavoprotein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (577 aa)
ykgEPutative hydroxyacid oxidoreductase (Fe-S centre); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (239 aa)
ybdHPutative oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (362 aa)
CAR16807.1Putative zinc-type alcohol dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (337 aa)
CAR16808.1Putative Short-chain dehydrogenase/reductase SDR precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (251 aa)
ybiCPutative hydroxyacid dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the LDH2/MDH2 oxidoreductase family. (361 aa)
yliIPQQ-dependent aldose sugar dehydrogenase precursor (asd); Function experimentally demonstrated in the studied species; enzyme. (371 aa)
dldD-lactate dehydrogenase, FAD-binding, NADH independent; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (585 aa)
gatDGalactitol-1-phosphate dehydrogenase, Zn-dependent and NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme. (346 aa)
fclGDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
rmlDdTDP-4-dehydrorhamnose reductase subunit, NAD(P)-binding, of dTDP-L-rhamnose synthase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (299 aa)
gndGluconate-6-phosphate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
ugdUDP-glucose 6-dehydrogenase; Function experimentally demonstrated in the studied species; enzyme. (388 aa)
hisDBifunctional histidinal dehydrogenase and histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
yeaUPutative tartrate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (361 aa)
ydjJPutative iditol dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (347 aa)
chbFCryptic phospho-beta-glucosidase, NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme. (450 aa)
CAR17487.1Putative 2-hydroxyacid dehydrogenase/reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
ydiBQuinate/shikimate 5-dehydrogenase, NAD(P)-binding; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. (288 aa)
hdhA7-alpha-hydroxysteroid dehydrogenase, NAD-dependent; Function experimentally demonstrated in the studied species; enzyme. (255 aa)
adhEFused acetaldehyde-CoA dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (891 aa)
ldhAFermentative D-lactate dehydrogenase, NAD-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa)
adhPAlcohol dehydrogenase, 1-propanol preferring; Function experimentally demonstrated in the studied species; carrier. (336 aa)
sfcAMalate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme); Function experimentally demonstrated in the studied species; enzyme; Belongs to the malic enzymes family. (565 aa)
uxaBAltronate oxidoreductase, NAD-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannitol dehydrogenase family. UxaB subfamily. (483 aa)
ydfIPutative mannonate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the mannitol dehydrogenase family. (486 aa)
icd-2Isocitrate dehydrogenase, specific for NADP+; Function experimentally demonstrated in the studied species; extrachromosomal origin. (416 aa)
fabG3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
ycdW2-ketoacid reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa)
rutEOxidoreductase subunit of the alternative pyrimidine degradation pathway; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted; Belongs to the nitroreductase family. HadB/RutE subfamily. (196 aa)
yeiQPutative sugar dehydrogenase, NAD-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the mannitol dehydrogenase family. (488 aa)
mqoMalate dehydrogenase, FAD/NAD(P)-binding domain; Function experimentally demonstrated in the studied species; enzyme. (548 aa)
glpASn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit, FAD/NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (542 aa)
glpBSn-glycerol-3-phosphate dehydrogenase (anaerobic), membrane anchor subunit; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor. (419 aa)
yfbGFused UDP-L-Ara4N formyltransferase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa)
pdxBErythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa)
yfcXFused enoyl-CoA hydratase and epimerase and isomerase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (714 aa)
eutGPutative alcohol dehydrogenase in ethanolamine utilization; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (395 aa)
maeBPutative fused malic enzyme oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (759 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
yphCPutative oxidoreductase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (353 aa)
ygaFPutative enzyme; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (422 aa)
srlDSorbitol-6-phosphate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
rffDUDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
ilvCKetol-acid reductoisomerase, NAD(P)-binding; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa)
gldAGlycerol dehydrogenase, NAD; Function experimentally demonstrated in the studied species; enzyme. (367 aa)
metLFused aspartokinase II; Function experimentally demonstrated in the studied species; enzyme; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa)
yihUPutative oxidoreductase with NAD(P)-binding Rossmann-fold domain; Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS); Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily. (298 aa)
fadBEnoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (729 aa)
fucOL-1,2-propanediol oxidoreductase; Function experimentally demonstrated in the studied species; enzyme. (383 aa)
kduD2-deoxy-D-gluconate 3-dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (253 aa)
serAD-3-phosphoglycerate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
glcFGlycolate oxidase iron-sulfur subunit; Function experimentally demonstrated in the studied species; carrier. (407 aa)
glcEGlycolate oxidase FAD binding subunit; Function experimentally demonstrated in the studied species; enzyme. (350 aa)
glcDGlycolate oxidase subunit, FAD-linked; Function experimentally demonstrated in the studied species; enzyme. (499 aa)
yghZAldo-keto reductase; Function experimentally demonstrated in the studied species; enzyme. (346 aa)
yqhDAlcohol dehydrogenase, NAD(P)-dependent; Function experimentally demonstrated in the studied species; enzyme. (387 aa)
dkgA2,5-diketo-D-gluconate reductase A; Function experimentally demonstrated in the studied species; enzyme. (275 aa)
garRTartronate semialdehyde reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate; Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily. (296 aa)
mdhMalate dehydrogenase, NAD(P)-binding; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
aroEDehydroshikimate reductase, NAD(P)-binding; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
glpDSn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (501 aa)
tiaE2-oxo-carboxylic acid reductase (glyoxalate reductase) (2-ketoaldonate reductase); Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (324 aa)
yiaK2,3-diketo-L-gulonate dehydrogenase, NADH-dependent; Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. (332 aa)
yiaYFe-containing alcohol dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (368 aa)
mtlDMannitol-1-phosphate dehydrogenase, NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme. (382 aa)
lldDL-lactate dehydrogenase, FMN-linked; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (396 aa)
gpsAGlycerol-3-phosphate dehydrogenase (NAD+); Function experimentally demonstrated in the studied species; enzyme; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa)
tdhThreonine 3-dehydrogenase, NAD(P)-binding; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
CAR20390.16-phospho-glucosidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (440 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding; Cell wall formation. (342 aa)
CAR20517.1Putative Shikimate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (270 aa)
melAAlpha-galactosidase, NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme. (451 aa)
idnO5-keto-D-gluconate-5-reductase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)
idnDL-idonate 5-dehydrogenase, NAD-binding; Function experimentally demonstrated in the studied species; enzyme. (343 aa)
yjgBPutative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (339 aa)
uxuBD-mannonate oxidoreductase, NAD-binding; Function experimentally demonstrated in the studied species; enzyme; Belongs to the mannitol dehydrogenase family. (486 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
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