STRINGSTRING
gntX gntX pfs pfs dgt dgt rnhB rnhB xseB xseB yafQ yafQ rnhA rnhA yedJ yedJ yciA yciA rnb rnb rne rne cdd cdd rihB rihB CAR18675.1 CAR18675.1 xseA xseA csrA csrA surE surE rhlB rhlB gpp gpp CAR19167.1 CAR19167.1 CAR19170.1 CAR19170.1 CAR19171.1 CAR19171.1 udp udp mazG mazG nudH nudH yqfB yqfB yggV yggV deaD deaD pnp pnp csrD csrD yrfA yrfA yrfB yrfB yrfC yrfC yrfD yrfD CAR19995.1 CAR19995.1 dut dut rph rph yicC yicC nudC nudC cpdB cpdB chpB chpB yjiK yjiK deoC deoC deoB deoB deoD deoD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gntXGluconate periplasmic binding protein with phosphoribosyltransferase domain, GNT I system; Function experimentally demonstrated in the studied species; transporter. (227 aa)
pfs5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] (232 aa)
dgtDeoxyguanosine triphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (505 aa)
rnhBRibonuclease HII, degrades RNA of DNA-RNA hybrids; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (198 aa)
xseBExonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa)
yafQToxin of the YafQ-DinJ toxin-antitoxin system; Function experimentally demonstrated in the studied species; factor. (82 aa)
rnhARibonuclease HI, degrades RNA of DNA-RNA hybrids; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (155 aa)
yedJPutative metal-dependent phosphohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (231 aa)
yciAPutative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (132 aa)
rnbRibonuclease II; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. (644 aa)
rneFused ribonucleaseE: endoribonuclease; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1061 aa)
cddCytidine/deoxycytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
rihBRibonucleoside hydrolase 2; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides; Belongs to the IUNH family. RihB subfamily. (313 aa)
CAR18675.1Conserved hypothetical protein. (309 aa)
xseAExonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (455 aa)
csrAPleiotropic regulatory protein for carbon source metabolism; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small [...] (61 aa)
surEBroad specificity 5'(3')-nucleotidase and polyphosphatase; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (253 aa)
rhlBATP-dependent RNA helicase; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (421 aa)
gppGuanosine pentaphosphatase/exopolyphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (494 aa)
CAR19167.1Putative phosphoesterase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the 5'-nucleotidase family. (519 aa)
CAR19170.1Putative 5'-nucleotidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the 5'-nucleotidase family. (517 aa)
CAR19171.1Putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the 5'-nucleotidase family. (541 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (256 aa)
mazGNucleoside triphosphate pyrophosphohydrolase; Function experimentally demonstrated in the studied species; enzyme. (263 aa)
nudHNucleotide hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (176 aa)
yqfBConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0267 family. (103 aa)
yggVdITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
deaDATP-dependent RNA helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (629 aa)
pnpPolynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (734 aa)
csrDInner membrane associated factor modulating specific RNAseE dependent RNA degradation pathways; Function experimentally demonstrated in the studied species; factor. (646 aa)
yrfAConserved hypothetical protein; Homologs of previously reported genes of unknown function. (134 aa)
yrfBConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (146 aa)
yrfCPutative fimbrial assembly protein (pilN-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure. (179 aa)
yrfDPutative pilus assembly protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (259 aa)
CAR19995.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (105 aa)
dutDeoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (151 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (246 aa)
yicCConserved hypothetical protein; Homologs of previously reported genes of unknown function. (287 aa)
nudCNADH pyrophosphatase; Function experimentally demonstrated in the studied species; enzyme. (257 aa)
cpdB2':3'-cyclic-nucleotide 2'-phosphodiesterase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the 5'-nucleotidase family. (647 aa)
chpBToxin of the ChpB-ChpS toxin-antitoxin system; Function experimentally demonstrated in the studied species; factor. (116 aa)
yjiKFragment of conserved hypothetical protein; Gene remnant; putative membrane component. (322 aa)
deoCFragment of conserved hypothetical protein (part 1); Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (259 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa)
deoDPurine-nucleoside phosphorylase; Function experimentally demonstrated in the studied species; enzyme. (239 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
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