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| | citC | Citrate lyase synthetase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (352 aa) |
| | citE | Citrate lyase, citryl-ACP lyase (beta) subunit; Function experimentally demonstrated in the studied species; enzyme; Belongs to the HpcH/HpaI aldolase family. (302 aa) |
| | citF | Citrate lyase, citrate-ACP transferase (alpha) subunit; Function experimentally demonstrated in the studied species; enzyme. (510 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | purK | N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa) |
| | mhpD | 2-keto-4-pentenoate hydratase; Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid. Belongs to the hydratase/decarboxylase family. MhpD subfamily. (269 aa) |
| | cynS | Cyanate aminohydrolase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family. (156 aa) |
| | cynT | Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (219 aa) |
| | prpD | 2-methylcitrate dehydratase; Function experimentally demonstrated in the studied species; enzyme. (483 aa) |
| | prpB | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (296 aa) |
| | acnB | Bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aconitase/IPM isomerase family. (865 aa) |
| | leuC | 3-isopropylmalate isomerase subunit, dehydratase component; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | leuD | 3-isopropylmalate isomerase subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | rluA | Pseudouridine synthase for 23S rRNA (position 746) and tRNAphe(position 32); Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (219 aa) |
| | caiD | Crotonobetainyl CoA hydratase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA. (297 aa) |
| | thrC | Threonine synthase; Function experimentally demonstrated in the studied species; enzyme. (428 aa) |
| | menB | Dihydroxynaphthoic acid synthetase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). (285 aa) |
| | menC | o-succinylbenzoyl-CoA synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (320 aa) |
| | yfaU | Putative 2,4-dihydroxyhept-2-ene-1,7-dioic acid-like aldolase; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily. (267 aa) |
| | CAR18496.1 | Mandelate racemase/muconate lactonizing enzyme family protein. (404 aa) |
| | ccmF | Heme lyase, CcmF subunit; Function experimentally demonstrated in the studied species; enzyme. (647 aa) |
| | ccmH | Heme lyase, CcmH subunit; Possible subunit of a heme lyase. (350 aa) |
| | rsuA | 16S rRNA pseudouridylate 516 synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pseudouridine synthase RsuA family. (231 aa) |
| | yeiN | Conserved hypothetical protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (312 aa) |
| | pflA | Pyruvate formate lyase activating enzyme 1; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (246 aa) |
| | pflB | Pyruvate formate lyase I; Function experimentally demonstrated in the studied species; enzyme. (760 aa) |
| | fabA | Beta-hydroxydecanoyl thioester dehydrase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (172 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (152 aa) |
| | rluC | 23S rRNA pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (319 aa) |
| | pabC | 4-amino-4-deoxychorismate lyase component of para-aminobenzoate synthase multienzyme complex; Function experimentally demonstrated in the studied species; enzyme. (269 aa) |
| | yceG | Putative conserved membrane associated protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (340 aa) |
| | purB | Adenylosuccinate lyase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | ymfC | 23S rRNA pseudouridine synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pseudouridine synthase RsuA family. (216 aa) |
| | CAR18035.1 | Putative Outer membrane autotransporter barrel, putative pectin lyase fold; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (882 aa) |
| | gadB | Glutamate decarboxylase B, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the group II decarboxylase family. (466 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa) |
| | acnA | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa) |
| | rluB | 23S rRNA pseudouridylate synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pseudouridine synthase RsuA family. (291 aa) |
| | trpE | Component I of anthranilate synthase; Function experimentally demonstrated in the studied species; enzyme. (520 aa) |
| | trpD | Fused glutamine amidotransferase (component II) of anthranilate synthase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa) |
| | trpC | Fused indole-3-glycerolphosphate synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the TrpC family. (452 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | adhE | Fused acetaldehyde-CoA dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (891 aa) |
| | chaC | Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (238 aa) |
| | emtA | Lytic murein endotransglycosylase E; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. (203 aa) |
| | fumC | Fumarate hydratase (fumarase C),aerobic Class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa) |
| | fumA | Fumarate hydratase (fumarase A), aerobic Class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa) |
| | malY | Bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon; Function experimentally demonstrated in the studied species; enzyme. (390 aa) |
| | nth | DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa) |
| | gloA | Glyoxalase I, Ni-dependent; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (135 aa) |
| | sufS | Selenocysteine lyase, PLP-dependent; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (252 aa) |
| | sdaA | L-serine deaminase I; Function experimentally demonstrated in the studied species; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | eda | 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase; Function experimentally demonstrated in the studied species; enzyme. (213 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (603 aa) |
| | yedO | D-cysteine desulfhydrase, PLP-dependent; Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. (328 aa) |
| | hisB | Fused histidinol-phosphatase; Function experimentally demonstrated in the studied species; enzyme; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisF | Imidazole glycerol phosphate synthase, catalytic subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | rmlB | dTDP-glucose 4,6 dehydratase, NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (361 aa) |
| | gmd | GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (373 aa) |
| | gatY | D-tagatose 1,6-bisphosphate aldolase 2, catalytic subunit; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol. (284 aa) |
| | fbaB | Fructose-bisphosphate aldolase class I; Function experimentally demonstrated in the studied species; enzyme. (350 aa) |
| | ltaE | L-allo-threonine aldolase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (333 aa) |
| | fsaA | Fructose-6-phosphate aldolase 1; Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction; Belongs to the transaldolase family. Type 3A subfamily. (220 aa) |
| | moaC | Molybdopterin biosynthesis, protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa) |
| | moaA | Molybdopterin biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa) |
| | CAR16838.1 | Methylaspartate ammonia-lyase (Beta-methylaspartase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (413 aa) |
| | CAR16837.1 | Putative 3-methylaspartate ammonia-lyase, glutamate mutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (456 aa) |
| | CAR16834.1 | Fumarate hydratase class I, beta subunit, aerobic (Fumarase); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (550 aa) |
| | hutH | Histidine ammonia-lyase (histidase) pre-protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (556 aa) |
| | hutU | Urocanate hydratase (Urocanase) (Imidazolonepropionate hydrolase); Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (598 aa) |
| | CAR16810.1 | Putative Altronate dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (398 aa) |
| | nei | Endonuclease VIII; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (263 aa) |
| | mhpE | 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase, class I; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (337 aa) |
| | hemB | Porphobilinogen synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the ALAD family. (324 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (320 aa) |
| | yaeR | Putative S-C lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (129 aa) |
| | ldcC | Lysine decarboxylase 2, constitutive; Function experimentally demonstrated in the studied species; enzyme. (713 aa) |
| | fabZ | (3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (151 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | can | Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (220 aa) |
| | speD | S-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (264 aa) |
| | deoC | Fragment of conserved hypothetical protein (part 1); Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (259 aa) |
| | yjjW | Putative pyruvate formate lyase activating enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (287 aa) |
| | uxuA | Mannonate hydrolase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family. (394 aa) |
| | CAR20770.1 | Putative acyl-CoA hydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa) |
| | ulaD | 3-keto-L-gulonate 6-phosphate decarboxylase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/KGPDC family. KGPDC subfamily. (216 aa) |
| | yjeF | Putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...] (515 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (322 aa) |
| | aspA | Aspartate ammonia-lyase; Function experimentally demonstrated in the studied species; enzyme. (478 aa) |
| | cadA | Lysine decarboxylase 1; Function experimentally demonstrated in the studied species; enzyme. (715 aa) |
| | fumB | Anaerobic class I fumarate hydratase (fumarase B); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa) |
| | adiA | Biodegradative arginine decarboxylase; Function experimentally demonstrated in the studied species; enzyme. (756 aa) |
| | phnG | Carbon-phosphorus lyase complex subunit; Function experimentally demonstrated in the studied species; enzyme. (150 aa) |
| | phnH | Carbon-phosphorus lyase complex subunit; Function experimentally demonstrated in the studied species; enzyme. (194 aa) |
| | phnI | Carbon-phosphorus lyase complex subunit; Function experimentally demonstrated in the studied species; enzyme. (354 aa) |
| | phnJ | Carbon-phosphorus lyase complex subunit; Catalyzes the breakage of the C-P bond in alpha-D-ribose 1- methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose. Belongs to the PhnJ family. (281 aa) |
| | phnK | Carbon-phosphorus lyase complex subunit; Function experimentally demonstrated in the studied species; enzyme. (252 aa) |
| | phnL | Carbon-phosphorus lyase complex subunit; Function experimentally demonstrated in the studied species; enzyme. (226 aa) |
| | phnM | Carbon-phosphorus lyase complex subunit; Function experimentally demonstrated in the studied species; enzyme. (378 aa) |
| | phnP | Carbon-phosphorus lyase complex accessory protein; Function experimentally demonstrated in the studied species; enzyme. (252 aa) |
| | nrfG | Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfG; Function experimentally demonstrated in the studied species; factor. (198 aa) |
| | nrfF | Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfF; Possible subunit of a heme lyase. (127 aa) |
| | nrfE | Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfE; Function experimentally demonstrated in the studied species; factor. (552 aa) |
| | ubiC | Chorismate pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway. (165 aa) |
| | yjbC | 23S rRNA pseudouridine synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pseudouridine synthase RsuA family. (290 aa) |
| | aceA | Isocitrate lyase; Function experimentally demonstrated in the studied species; enzyme. (434 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa) |
| | thiC | Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (631 aa) |
| | tnaA | tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the beta-eliminating lyase family. (471 aa) |
| | dgoA | 2-oxo-3-deoxygalactonate 6-phosphate aldolase; Function experimentally demonstrated in the studied species; enzyme. (205 aa) |
| | phr | Deoxyribodipyrimidine photolyase, FAD-binding; Function experimentally demonstrated in the studied species; enzyme; Belongs to the DNA photolyase family. (472 aa) |
| | dgoD | Galactonate dehydratase; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate. (382 aa) |
| | yeiN-2 | Conserved hypothetical protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (311 aa) |
| | dsdA-2 | D-serine ammonia-lyase; Function experimentally demonstrated in the studied species; enzyme. (443 aa) |
| | cutD | Putative pyruvate formate-lyase activating enzyme; Catalyzes activation of the choline trimethylamine-lyase CutC under anaerobic conditions by generation of an organic free radical on a glycine residue, via an homolytic cleavage of S-adenosyl-L-methionine (SAM). (315 aa) |
| | adhE-3 | Fragment of fused acetaldehyde-CoA dehydrogenase; Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde. Belongs to the glycyl radical enzyme (GRE) family. CutC subfamily. (1140 aa) |
| | CAR20287.1 | Putative fructose-bisphosphate aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (286 aa) |
| | dfp | Fused 4'-phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (406 aa) |
| | mutM | Formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (269 aa) |
| | sgbH | 3-keto-L-gulonate 6-phosphate decarboxylase; Function experimentally demonstrated in the studied species; enzyme. (220 aa) |
| | gadA | Glutamate decarboxylase A, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the group II decarboxylase family. (466 aa) |
| | pck | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (540 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (362 aa) |
| | cysG | Fused siroheme synthase 1, 3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (457 aa) |
| | GatY | Putative fructose/tagatose biphosphate aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (284 aa) |
| | nanA | N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (297 aa) |
| | elbB | Isoprenoid biosynthesis protein with amidotransferase-like domain; Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate; Belongs to the peptidase C56 family. (217 aa) |
| | truB | tRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (314 aa) |
| | kbaY | Tagatose 6-phosphate aldolase 1, kbaY subunit; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability. (286 aa) |
| | garD | (D)-galactarate dehydrogenase; Catalyzes the dehydration of galactarate to form 5-dehydro-4- deoxy-D-glucarate. (523 aa) |
| | garL | alpha-dehydro-beta-deoxy-D-glucarate aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. (256 aa) |
| | tdcB | Catabolic threonine dehydratase, PLP-dependent; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (329 aa) |
| | tdcE | Pyruvate formate-lyase 4/2-ketobutyrate formate-lyase; Function experimentally demonstrated in the studied species; enzyme. (764 aa) |
| | tdcG | L-serine dehydratase 3; Function experimentally demonstrated in the studied species; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | uxaA | Altronate hydrolase; Function experimentally demonstrated in the studied species; enzyme. (495 aa) |
| | ttdB | L-tartrate dehydratase, beta subunit; Function experimentally demonstrated in the studied species; enzyme. (201 aa) |
| | ttdA | L-tartrate dehydratase, alpha subunit; Function experimentally demonstrated in the studied species; enzyme. (303 aa) |
| | folB | Bifunctioal dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (122 aa) |
| | ribB | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (217 aa) |
| | metC | Cystathionine beta-lyase, PLP-dependent; Function experimentally demonstrated in the studied species; enzyme. (395 aa) |
| | speC | Ornithine decarboxylase, constitutive; Function experimentally demonstrated in the studied species; enzyme. (711 aa) |
| | mltC | Membrane-bound lytic murein transglycosylase C; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (359 aa) |
| | speA | Biosynthetic arginine decarboxylase, PLP-binding; Catalyzes the biosynthesis of agmatine from arginine. (658 aa) |
| | fbaA | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | ygfG | methylmalonyl-CoA decarboxylase, biotin-independent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa) |
| | ygeX | 2,3-diaminopropionate ammonia-lyase; Function experimentally demonstrated in the studied species; enzyme. (398 aa) |
| | lysA | Diaminopimelate decarboxylase, PLP-binding; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | mltA | Membrane-bound lytic murein transglycosylase A; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (365 aa) |
| | csdA | Cysteine sulfinate desulfinase; Function experimentally demonstrated in the studied species; enzyme. (401 aa) |
| | fucA | L-fuculose-1-phosphate aldolase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (215 aa) |
| | sdaB | L-serine deaminase II; Function experimentally demonstrated in the studied species; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) |
| | truC | tRNA pseudouridine synthase; Function experimentally demonstrated in the studied species; enzyme. (260 aa) |
| | gudX | Glucarate dehydratase; Function of strongly homologous gene; enzyme. (446 aa) |
| | gudD | Fragment of hybrid sensory histidine kinase, in two-component regulatory system with UvrY (part 2); Gene remnant; regulator. (446 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa) |
| | ubiD | 3-octaprenyl-4-hydroxybenzoate decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (497 aa) |
| | fadB | Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (729 aa) |
| | yihT | Putative aldolase; Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). Belongs to the aldolase LacD family. (292 aa) |
| | rhaD | Rhamnulose-1-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. Belongs to the aldolase class II family. RhaD subfamily. (274 aa) |
| | fsaB | Fructose-6-phosphate aldolase 2; Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction; Belongs to the transaldolase family. Type 3A subfamily. (220 aa) |
| | pflD | Putative formate acetyltransferase 2 (pyruvate formate lyase II); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (765 aa) |
| | pflC | Pyruvate formate lyase II activase; Function experimentally demonstrated in the studied species; enzyme. (292 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (883 aa) |
| | argH | Argininosuccinate lyase; Function experimentally demonstrated in the studied species; enzyme. (457 aa) |
| | ilvD | Dihydroxyacid dehydratase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the IlvD/Edd family. (616 aa) |
| | ilvA | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa) |
| | rffG | dTDP-glucose 4,6-dehydratase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (355 aa) |
| | hemD | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (246 aa) |
| | cyaA | Adenylate cyclase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the adenylyl cyclase class-1 family. (848 aa) |
| | ygcF | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa) |
| | ygcM | 6-pyruvoyl tetrahydrobiopterin synthase (PTPS); Function experimentally demonstrated in the studied species; enzyme. (121 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa) |
| | CAR19046.1 | Conserved putative non-oxidative hydroxyarylic acid decarboxylase activity; Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives. (475 aa) |
| | hycF | Formate hydrogenlyase complex iron-sulfur protein; Function experimentally demonstrated in the studied species; carrier. (180 aa) |
| | luxS | S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa) |
| | pheA | Fused chorismate mutase P; Function experimentally demonstrated in the studied species; enzyme. (386 aa) |
| | rluD | 23S rRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (326 aa) |
| | yfhD | Putative transglycosylase; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (472 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | eutA | Fragment of ethanolamine ammonia-lyase, large subunit, heavy chain (part 1); Gene remnant; enzyme. (467 aa) |
| | eutC | Ethanolamine ammonia-lyase, small subunit (light chain); Function experimentally demonstrated in the studied species; enzyme; Belongs to the EutC family. (295 aa) |
| | yfeU | Putative PTS component; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (298 aa) |
| | dsdA | D-serine ammonia-lyase; Function experimentally demonstrated in the studied species; enzyme. (443 aa) |
| | yfcX | Fused enoyl-CoA hydratase and epimerase and isomerase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (714 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (189 aa) |
| | CAR18579.1 | Cystathionine gamma-synthase (CGS) (O-succinylhomoserine (thiol)-lyase). (405 aa) |
| | yfbB | Putative thioesterase, menaquinone synthesis; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). (252 aa) |
| | speF | Ornithine decarboxylase isozyme, inducible; Function experimentally demonstrated in the studied species; enzyme. (732 aa) |
| | rlpA | Minor lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (362 aa) |
