STRINGSTRING
pgm pgm gpt gpt phoE phoE lacZ lacZ hemB hemB sbcD sbcD bolA bolA apt apt ibpA ibpA pgi pgi fklB fklB deoC deoC CAR18813.1 CAR18813.1 yphA yphA alaS alaS ebgA ebgA ygjK ygjK yqjF yqjF fkpA fkpA ibpB ibpB pdxK pdxK ompC ompC cdd cdd serS serS ompF ompF pncB pncB pepN pepN yccA yccA flgL flgL CAR17865.1 CAR17865.1 ompN ompN uidA uidA pdxY pdxY katE katE fliC fliC CAR17225.1 CAR17225.1 yedX yedX ybhM ybhM ybhL ybhL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pgmPhosphoglucomutase; Function experimentally demonstrated in the studied species; enzyme. (546 aa)
gptGuanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa)
phoEOuter membrane phosphoporin protein E; Function experimentally demonstrated in the studied species; transporter; Belongs to the Gram-negative porin family. (351 aa)
lacZbeta-D-galactosidase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the glycosyl hydrolase 2 family. (1024 aa)
hemBPorphobilinogen synthase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the ALAD family. (324 aa)
sbcDExonuclease, dsDNA, ATP-dependent; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (400 aa)
bolARegulator of penicillin binding proteins and beta lactamase transcription (morphogene); Function experimentally demonstrated in the studied species; regulator; Belongs to the BolA/IbaG family. (105 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa)
ibpAHeat shock chaperone; Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent. (137 aa)
pgiGlucosephosphate isomerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the GPI family. (549 aa)
fklBFKBP-type peptidyl-prolyl cis-trans isomerase (rotamase); Function experimentally demonstrated in the studied species; enzyme. (206 aa)
deoCFragment of conserved hypothetical protein (part 1); Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (259 aa)
CAR18813.1Conserved hypothetical protein from phage origin; Homologs of previously reported genes of unknown function; extrachromosomal origin. (188 aa)
yphAConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (164 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. (876 aa)
ebgACryptic beta-D-galactosidase, alpha subunit; Function experimentally demonstrated in the studied species; enzyme. (1030 aa)
ygjKPutative glycosyl hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (783 aa)
yqjFPutative quinol oxidase subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (130 aa)
fkpAFKBP-type peptidyl-prolyl cis-trans isomerase (rotamase); Function experimentally demonstrated in the studied species; enzyme. (270 aa)
ibpBHeat shock chaperone; Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent. (142 aa)
pdxKPyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. (283 aa)
ompCOuter membrane porin protein C; Function experimentally demonstrated in the studied species; transporter; Belongs to the Gram-negative porin family. (364 aa)
cddCytidine/deoxycytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
serSseryl-tRNA synthetase, also charges selenocysteinyl-tRNA with serine; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa)
ompFOuter membrane porin 1a (Ia;b;F); Function experimentally demonstrated in the studied species; transporter; Belongs to the Gram-negative porin family. (357 aa)
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (400 aa)
pepNFunction experimentally demonstrated in the studied species; enzyme. (870 aa)
yccAConserved hypothetical protein; Homologs of previously reported genes of unknown function; membrane component; Belongs to the BI1 family. (219 aa)
flgLFlagellar hook-filament junction protein; Function experimentally demonstrated in the studied species; structure. (317 aa)
CAR17865.1Outer membrane porin protein ompD precursor; Function of homologous gene experimentally demonstrated in an other organism; membrane component; Belongs to the Gram-negative porin family. (366 aa)
ompNOuter membrane pore protein N, non-specific; Function experimentally demonstrated in the studied species; transporter. (377 aa)
uidAbeta-D-glucuronidase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the glycosyl hydrolase 2 family. (603 aa)
pdxYPyridoxal kinase 2/pyridoxine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (287 aa)
katEHydroperoxidase HPII(III) (catalase); Serves to protect cells from the toxic effects of hydrogen peroxide. (753 aa)
fliCFlagellar filament structural protein, flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (568 aa)
CAR17225.1Outer membrane protein N precursor (porin); Function of strongly homologous gene; membrane component. (375 aa)
yedXConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (137 aa)
ybhMConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component. (237 aa)
ybhLConserved hypothetical protein; Homologs of previously reported genes of unknown function; putative membrane component; Belongs to the BI1 family. (234 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
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