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aceE aceE aceF aceF lpd lpd frmA frmA pgm pgm gpmA gpmA galM galM fbaB fbaB pykA pykA yeaD yeaD gapA gapA chbF chbF pfkB pfkB pps pps pykF pykF malX malX adhE adhE ydbK ydbK adhP adhP CelA CelA ptsG ptsG agp agp glk glk crr crr eutG eutG ascF ascF ascB ascB glpX glpX tpiA tpiA pfkA pfkA yihX yihX yihR yihR eno eno bglA bglA fbaA fbaA pgk pgk yggF yggF pck pck aldB aldB yiaY yiaY gpmI gpmI CAR20287.1 CAR20287.1 CAR20288.1 CAR20288.1 pgi pgi acs acs fbp fbp yjgB yjgB ytjC ytjC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aceEPyruvate dehydrogenase, decarboxylase component E1, thiamin-binding; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
aceFPyruvate dehydrogenase, dihydrolipoyltransacetylase component E2; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (630 aa)
lpdLipoamide dehydrogenase, E3 component is part of three enzyme complexes; Function experimentally demonstrated in the studied species; enzyme. (474 aa)
frmAAlcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
pgmPhosphoglucomutase; Function experimentally demonstrated in the studied species; enzyme. (546 aa)
gpmAPhosphoglyceromutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa)
galMGalactose-1-epimerase (mutarotase); Converts alpha-aldose to the beta-anomer. (346 aa)
fbaBFructose-bisphosphate aldolase class I; Function experimentally demonstrated in the studied species; enzyme. (350 aa)
pykAPyruvate kinase II; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pyruvate kinase family. (480 aa)
yeaDConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the glucose-6-phosphate 1-epimerase family. (294 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase A; Function experimentally demonstrated in the studied species; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
chbFCryptic phospho-beta-glucosidase, NAD(P)-binding; Function experimentally demonstrated in the studied species; enzyme. (450 aa)
pfkB6-phosphofructokinase II; Function experimentally demonstrated in the studied species; enzyme; Belongs to the carbohydrate kinase PfkB family. (309 aa)
ppsPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa)
pykFPyruvate kinase I; Function experimentally demonstrated in the studied species; enzyme; Belongs to the pyruvate kinase family. (470 aa)
malXFused maltose and glucose-specific PTS enzymes: IIB and IIC components; Function experimentally demonstrated in the studied species; transporter. (530 aa)
adhEFused acetaldehyde-CoA dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (891 aa)
ydbKPutative 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (1174 aa)
adhPAlcohol dehydrogenase, 1-propanol preferring; Function experimentally demonstrated in the studied species; carrier. (336 aa)
CelAPutative 6-phospho-beta-glucosidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the glycosyl hydrolase 1 family. (481 aa)
ptsGFragment of ferric-rhodotorulic acid outer membrane transporter (part 2); Gene remnant; transporter. (477 aa)
agpGlucose-1-phosphatase/inositol phosphatase; Function experimentally demonstrated in the studied species; enzyme. (413 aa)
glkGlucokinase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the bacterial glucokinase family. (321 aa)
crrGlucose-specific enzyme IIA component of PTS; Function experimentally demonstrated in the studied species; transporter. (169 aa)
eutGPutative alcohol dehydrogenase in ethanolamine utilization; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (395 aa)
ascFFused cellobiose/arbutin/salicin-specific PTS enzymes: IIB component; Function experimentally demonstrated in the studied species; transporter. (485 aa)
ascBCryptic 6-phospho-beta-glucosidase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the glycosyl hydrolase 1 family. (474 aa)
glpXFructose 1,6-bisphosphatase II; Function experimentally demonstrated in the studied species; enzyme. (336 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
pfkA6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
yihXPutative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (199 aa)
yihRPutative aldose-1-epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (303 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa)
bglAFunction experimentally demonstrated in the studied species; enzyme; Belongs to the glycosyl hydrolase 1 family. (479 aa)
fbaAFructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
pgkPhosphoglycerate kinase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the phosphoglycerate kinase family. (387 aa)
yggFPutative hexoseP phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (321 aa)
pckPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (540 aa)
aldBAldehyde dehydrogenase B; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aldehyde dehydrogenase family. (512 aa)
yiaYFe-containing alcohol dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (368 aa)
gpmIPhosphoglycero mutase III, cofactor-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa)
CAR20287.1Putative fructose-bisphosphate aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (286 aa)
CAR20288.1Putative sugar aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (283 aa)
pgiGlucosephosphate isomerase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the GPI family. (549 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa)
fbpFragment of putative sugar transporter subunit: membrane component of ABC superfamily (part 2); Gene remnant; putative transporter. (332 aa)
yjgBPutative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (339 aa)
ytjCPhosphoglyceromutase 2, co-factor independent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
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