(24 nodes) Glutathione metabolism network (Escherichia coli IAI39)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	speE	Spermidine synthase (putrescine aminopropyltransferase); Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (288 aa)
	pepD	Aminoacyl-histidine dipeptidase (peptidase D); Function experimentally demonstrated in the studied species; enzyme. (485 aa)
	ybdK	Gamma-glutamyl:cysteine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity. (372 aa)
	speF	Ornithine decarboxylase isozyme, inducible; Function experimentally demonstrated in the studied species; enzyme. (732 aa)
	ybgJ	Putative hydrolase subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (218 aa)
	ybgK	Putative hydrolase subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (310 aa)
	ybgL	Putative lactam utilization protein, UPF0271 family; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (244 aa)
	yliJ	Putative glutathione S-transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (208 aa)
	gnd	Gluconate-6-phosphate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
	zwf	Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
	btuE	Putative glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent. (183 aa)
	gst	Glutathionine S-transferase; Function experimentally demonstrated in the studied species; enzyme. (201 aa)
	chaC	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (238 aa)
	icd-2	Isocitrate dehydrogenase, specific for NADP+; Function experimentally demonstrated in the studied species; extrachromosomal origin. (416 aa)
	pepN	Function experimentally demonstrated in the studied species; enzyme. (870 aa)
	yfcF	Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (214 aa)
	pepB	Aminopeptidase B; Probably plays an important role in intracellular peptide degradation. (427 aa)
	gshA	Gamma-glutamate-cysteine ligase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (518 aa)
	gshB	Glutathione synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the prokaryotic GSH synthase family. (316 aa)
	speC	Ornithine decarboxylase, constitutive; Function experimentally demonstrated in the studied species; enzyme. (711 aa)
	gss	Fused glutathionylspermidine amidase; Function experimentally demonstrated in the studied species; enzyme. (619 aa)
	ggt	Gamma-glutamyltranspeptidase; Function experimentally demonstrated in the studied species; enzyme. (590 aa)
	gor	Glutathione oxidoreductase; Function experimentally demonstrated in the studied species; carrier. (450 aa)
	pepA	Aminopeptidase A, a cyteinylglycinase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (503 aa)

Your Current Organism:

Escherichia coli IAI39

NCBI taxonomy Id: 585057
Other names: E. coli IAI39

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
btuE	chaC	ECIAI39_1343	ECIAI39_1556	Putative glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.900
btuE	ggt	ECIAI39_1343	ECIAI39_3927	Putative glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.	Gamma-glutamyltranspeptidase; Function experimentally demonstrated in the studied species; enzyme.	0.918
btuE	gor	ECIAI39_1343	ECIAI39_3990	Putative glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.	Glutathione oxidoreductase; Function experimentally demonstrated in the studied species; carrier.	0.964
btuE	gshB	ECIAI39_1343	ECIAI39_3365	Putative glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.	Glutathione synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the prokaryotic GSH synthase family.	0.919
btuE	gss	ECIAI39_1343	ECIAI39_3484	Putative glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.	Fused glutathionylspermidine amidase; Function experimentally demonstrated in the studied species; enzyme.	0.900
btuE	gst	ECIAI39_1343	ECIAI39_1420	Putative glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.	Glutathionine S-transferase; Function experimentally demonstrated in the studied species; enzyme.	0.913
btuE	yfcF	ECIAI39_1343	ECIAI39_2448	Putative glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.	Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.916
btuE	yliJ	ECIAI39_1343	ECIAI39_0817	Putative glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.	Putative glutathione S-transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.916
chaC	btuE	ECIAI39_1556	ECIAI39_1343	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Putative glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.	0.900
chaC	ggt	ECIAI39_1556	ECIAI39_3927	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Gamma-glutamyltranspeptidase; Function experimentally demonstrated in the studied species; enzyme.	0.903
chaC	gor	ECIAI39_1556	ECIAI39_3990	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione oxidoreductase; Function experimentally demonstrated in the studied species; carrier.	0.900
chaC	gshB	ECIAI39_1556	ECIAI39_3365	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione synthetase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the prokaryotic GSH synthase family.	0.904
chaC	gss	ECIAI39_1556	ECIAI39_3484	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Fused glutathionylspermidine amidase; Function experimentally demonstrated in the studied species; enzyme.	0.900
chaC	gst	ECIAI39_1556	ECIAI39_1420	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathionine S-transferase; Function experimentally demonstrated in the studied species; enzyme.	0.900
chaC	pepA	ECIAI39_1556	ECIAI39_4733	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Aminopeptidase A, a cyteinylglycinase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.900
chaC	pepB	ECIAI39_1556	ECIAI39_2724	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Aminopeptidase B; Probably plays an important role in intracellular peptide degradation.	0.900
chaC	pepD	ECIAI39_1556	ECIAI39_0414	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Aminoacyl-histidine dipeptidase (peptidase D); Function experimentally demonstrated in the studied species; enzyme.	0.900
chaC	pepN	ECIAI39_1556	ECIAI39_2215	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Function experimentally demonstrated in the studied species; enzyme.	0.900
chaC	ybgJ	ECIAI39_1556	ECIAI39_0663	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Putative hydrolase subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.900
chaC	ybgK	ECIAI39_1556	ECIAI39_0664	Regulatory protein for cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Putative hydrolase subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.900