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ftsI ftsI murE murE murF murF mraY mraY murD murD murG murG murC murC ddlB ddlB mrcB mrcB ispU ispU ddlA ddlA dacA dacA mrdA mrdA dacC dacC ybjG ybjG dacD dacD murQ murQ pbpC pbpC bacA bacA dacB dacB murA murA mtgA mtgA mrcA mrcA murB murB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ftsITranspeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (588 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (495 aa)
murFUDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa)
murDUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (438 aa)
murGN-acetylglucosaminyl transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa)
murCUDP-N-acetylmuramate:L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (491 aa)
ddlBD-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa)
mrcBFused glycosyl transferase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (844 aa)
ispUUndecaprenyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (253 aa)
ddlAD-alanine-D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (364 aa)
dacAD-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5); Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S11 family. (403 aa)
mrdATranspeptidase involved in peptidoglycan synthesis (penicillin-binding protein 2); Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa)
dacCD-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6a); Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S11 family. (400 aa)
ybjGUndecaprenyl pyrophosphate phosphatase; Function experimentally demonstrated in the studied species; enzyme. (198 aa)
dacDD-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6b); Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S11 family. (388 aa)
murQD-lactyl ether N-acetylmuramic-6-phosphate acid etherase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the peptidase S12 family. YfeW subfamily. (432 aa)
pbpCFused transglycosylase; Function experimentally demonstrated in the studied species; enzyme. (770 aa)
bacAUndecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (273 aa)
dacBD-alanyl-D-alanine carboxypeptidase; Function experimentally demonstrated in the studied species; enzyme. (477 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
mtgABiosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (242 aa)
mrcAFused penicillin-binding protein 1a: murein transglycosylase; Function experimentally demonstrated in the studied species; enzyme. (850 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding; Cell wall formation. (342 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
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