STRINGSTRING
nadC nadC nadD nadD nadA nadA pncA pncA nadE nadE pntA pntA pntB pntB yneI yneI cobB cobB pncB pncB nadB nadB yfjB yfjB gabD gabD ygaD ygaD surE surE sthA sthA CAR19167.1 CAR19167.1 mazG mazG yrfG yrfG nudC nudC yjjG yjjG deoD deoD nadR nadR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nadCQuinolinate phosphoribosyltransferase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the NadC/ModD family. (297 aa)
nadDNicotinic acid mononucleotide adenylyltransferase, NAD(P)-dependent; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (213 aa)
nadAQuinolinate synthase, subunit A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (347 aa)
pncANicotinamidase/pyrazinamidase; Function experimentally demonstrated in the studied species; enzyme. (213 aa)
nadENAD synthetase, NH3/glutamine-dependent; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa)
pntAPyridine nucleotide transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. (510 aa)
pntBPyridine nucleotide transhydrogenase, beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (462 aa)
yneIPutative aldehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (462 aa)
cobBDeacetylase of acetyl-CoA synthetase, NAD-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the sirtuin family. Class III subfamily. (273 aa)
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (400 aa)
nadBQuinolinate synthase, L-aspartate oxidase (B protein) subunit; Catalyzes the oxidation of L-aspartate to iminoaspartate. (540 aa)
yfjBNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa)
gabDSuccinate-semialdehyde dehydrogenase I, NADP-dependent; Function experimentally demonstrated in the studied species; enzyme; Belongs to the aldehyde dehydrogenase family. (482 aa)
ygaDConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the CinA family. (165 aa)
surEBroad specificity 5'(3')-nucleotidase and polyphosphatase; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (253 aa)
sthAPyridine nucleotide transhydrogenase, soluble; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (466 aa)
CAR19167.1Putative phosphoesterase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the 5'-nucleotidase family. (519 aa)
mazGNucleoside triphosphate pyrophosphohydrolase; Function experimentally demonstrated in the studied species; enzyme. (263 aa)
yrfGPutative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (222 aa)
nudCNADH pyrophosphatase; Function experimentally demonstrated in the studied species; enzyme. (257 aa)
yjjGdUMP phosphatase; Function experimentally demonstrated in the studied species; enzyme. (225 aa)
deoDPurine-nucleoside phosphorylase; Function experimentally demonstrated in the studied species; enzyme. (239 aa)
nadRBifunctional DNA-binding transcriptional repressor and NMN adenylyltransferase; Function experimentally demonstrated in the studied species; regulator. (410 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.