(21 nodes) beta-Lactam resistance network (Escherichia coli IAI39)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ftsI	Transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (588 aa)
	acrA	Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (397 aa)
	ampG	Muropeptide transporter; Function experimentally demonstrated in the studied species; transporter. (491 aa)
	CAR16555.1	Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (383 aa)
	mrdA	Transpeptidase involved in peptidoglycan synthesis (penicillin-binding protein 2); Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa)
	CAR17225.1	Outer membrane protein N precursor (porin); Function of strongly homologous gene; membrane component. (375 aa)
	oppA	Oligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter. (543 aa)
	oppB	Oligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter. (306 aa)
	oppC	Oligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter. (302 aa)
	oppD	Oligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (337 aa)
	oppF	Oligopeptide transporter subunit; Function experimentally demonstrated in the studied species; transporter; Belongs to the ABC transporter superfamily. (334 aa)
	CAR17764.1	Putative efflux protein, membrane fusion (MFP) family precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (383 aa)
	CAR17769.1	Putative efflux pump (Putative multidrug-efflux transport protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (1035 aa)
	CAR17770.1	Putative outer membrane channel protein of an efflux system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (457 aa)
	mppA	Murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit; Function experimentally demonstrated in the studied species; transporter. (537 aa)
	nagZ	Beta N-acetyl-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (341 aa)
	ompF	Outer membrane porin 1a (Ia;b;F); Function experimentally demonstrated in the studied species; transporter; Belongs to the Gram-negative porin family. (357 aa)
	ompC	Outer membrane porin protein C; Function experimentally demonstrated in the studied species; transporter; Belongs to the Gram-negative porin family. (364 aa)
	tolC	Transport channel; Function experimentally demonstrated in the studied species; transporter. (493 aa)
	mrcA	Fused penicillin-binding protein 1a: murein transglycosylase; Function experimentally demonstrated in the studied species; enzyme. (850 aa)
	ampC	beta-lactamase/D-alanine carboxypeptidase; Function experimentally demonstrated in the studied species; enzyme. (377 aa)

Your Current Organism:

Escherichia coli IAI39

NCBI taxonomy Id: 585057
Other names: E. coli IAI39

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAR17225.1	ompF	ECIAI39_1091	ECIAI39_2218	Outer membrane protein N precursor (porin); Function of strongly homologous gene; membrane component.	Outer membrane porin 1a (Ia;b;F); Function experimentally demonstrated in the studied species; transporter; Belongs to the Gram-negative porin family.	0.904
CAR17225.1	tolC	ECIAI39_1091	ECIAI39_3532	Outer membrane protein N precursor (porin); Function of strongly homologous gene; membrane component.	Transport channel; Function experimentally demonstrated in the studied species; transporter.	0.672
CAR17764.1	CAR17769.1	ECIAI39_1633	ECIAI39_1638	Putative efflux protein, membrane fusion (MFP) family precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Putative efflux pump (Putative multidrug-efflux transport protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.986
CAR17764.1	CAR17770.1	ECIAI39_1633	ECIAI39_1639	Putative efflux protein, membrane fusion (MFP) family precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Putative outer membrane channel protein of an efflux system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.965
CAR17764.1	acrA	ECIAI39_1633	ECIAI39_0208	Putative efflux protein, membrane fusion (MFP) family precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.905
CAR17764.1	tolC	ECIAI39_1633	ECIAI39_3532	Putative efflux protein, membrane fusion (MFP) family precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Transport channel; Function experimentally demonstrated in the studied species; transporter.	0.953
CAR17769.1	CAR17764.1	ECIAI39_1638	ECIAI39_1633	Putative efflux pump (Putative multidrug-efflux transport protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Putative efflux protein, membrane fusion (MFP) family precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.986
CAR17769.1	CAR17770.1	ECIAI39_1638	ECIAI39_1639	Putative efflux pump (Putative multidrug-efflux transport protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Putative outer membrane channel protein of an efflux system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.993
CAR17769.1	acrA	ECIAI39_1638	ECIAI39_0208	Putative efflux pump (Putative multidrug-efflux transport protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.987
CAR17769.1	tolC	ECIAI39_1638	ECIAI39_3532	Putative efflux pump (Putative multidrug-efflux transport protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Transport channel; Function experimentally demonstrated in the studied species; transporter.	0.957
CAR17770.1	CAR17764.1	ECIAI39_1639	ECIAI39_1633	Putative outer membrane channel protein of an efflux system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Putative efflux protein, membrane fusion (MFP) family precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.965
CAR17770.1	CAR17769.1	ECIAI39_1639	ECIAI39_1638	Putative outer membrane channel protein of an efflux system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Putative efflux pump (Putative multidrug-efflux transport protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.993
CAR17770.1	acrA	ECIAI39_1639	ECIAI39_0208	Putative outer membrane channel protein of an efflux system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.965
CAR17770.1	tolC	ECIAI39_1639	ECIAI39_3532	Putative outer membrane channel protein of an efflux system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Transport channel; Function experimentally demonstrated in the studied species; transporter.	0.907
acrA	CAR17764.1	ECIAI39_0208	ECIAI39_1633	Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Putative efflux protein, membrane fusion (MFP) family precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.905
acrA	CAR17769.1	ECIAI39_0208	ECIAI39_1638	Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Putative efflux pump (Putative multidrug-efflux transport protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.987
acrA	CAR17770.1	ECIAI39_0208	ECIAI39_1639	Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Putative outer membrane channel protein of an efflux system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.965
acrA	ompF	ECIAI39_0208	ECIAI39_2218	Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Outer membrane porin 1a (Ia;b;F); Function experimentally demonstrated in the studied species; transporter; Belongs to the Gram-negative porin family.	0.630
acrA	tolC	ECIAI39_0208	ECIAI39_3532	Multidrug efflux system; Function experimentally demonstrated in the studied species; transporter; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Transport channel; Function experimentally demonstrated in the studied species; transporter.	0.999
ampC	ampG	ECIAI39_4617	ECIAI39_0240	beta-lactamase/D-alanine carboxypeptidase; Function experimentally demonstrated in the studied species; enzyme.	Muropeptide transporter; Function experimentally demonstrated in the studied species; transporter.	0.825