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dksA dksA yaiC yaiC mlrA mlrA yegE yegE wza wza yedQ yedQ rcsA rcsA fliA fliA fliZ fliZ sdiA sdiA uvrY uvrY flhD flhD adrB adrB ycgR ycgR gmr gmr ydaM ydaM flgM flgM csgC csgC csgA csgA csgB csgB csgD csgD pgaA pgaA pgaB pgaB pgaC pgaC pgaD pgaD rcsD rcsD rcsB rcsB rcsC rcsC crr crr gcvR gcvR luxS luxS csrA csrA rpoS rpoS cyaA cyaA oxyR oxyR gcvA gcvA arcB arcB crp crp envZ envZ ompR ompR malP malP glgP glgP glgA glgA glgC glgC yhjH yhjH bcsA bcsA arcA arcA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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dksADNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. (151 aa)
yaiCPutative diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (371 aa)
mlrADNA-binding transcriptional regulator; Function experimentally demonstrated in the studied species; regulator. (215 aa)
yegEPutative diguanylate cyclase, GGDEF domain signalling protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (1105 aa)
wzaLipoprotein required for capsular polysaccharide translocation through the outer membrane; Function of strongly homologous gene; lipoprotein. (379 aa)
yedQPutative diguanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (564 aa)
rcsADNA-binding transcriptional activator, co-regulator with RcsB; Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes. (207 aa)
fliARNA polymerase, sigma 28 (sigma F) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa)
fliZPutative regulator of FliA activity; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (183 aa)
sdiADNA-binding transcriptional activator; Function experimentally demonstrated in the studied species; regulator. (240 aa)
uvrYDNA-binding response regulator in two-component regulatory system with BarA; Function experimentally demonstrated in the studied species; regulator. (218 aa)
flhDDNA-binding transcriptional dual regulator with FlhC; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (119 aa)
adrBPutative cyclic di-GMP phosphodiesterase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (532 aa)
ycgRProtein involved in flagellar function; Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility. (244 aa)
gmrModulator of Rnase II stability; Function experimentally demonstrated in the studied species; putative factor. (661 aa)
ydaMPutative diguanylate cyclase, GG[D/E]EF domain signalling protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (410 aa)
flgMAnti-sigma factor for FliA (sigma 28); Function experimentally demonstrated in the studied species; factor. (96 aa)
csgCPutative curli production protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (110 aa)
csgACryptic curlin major subunit; Function experimentally demonstrated in the studied species; structure. (151 aa)
csgBCurlin nucleator protein, minor subunit in curli complex; Function experimentally demonstrated in the studied species; factor. (151 aa)
csgDDNA-binding transcriptional activator in two-component regulatory system; Function experimentally demonstrated in the studied species; regulator. (216 aa)
pgaAPutative outer membrane protein associated with biofilm formation; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (807 aa)
pgaBPutative polysaccharide deacetylase associated with biofilm formation; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (672 aa)
pgaCPutative glycosyl transferase associated with biofilm formation; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (424 aa)
pgaDPutative inner membrane protein associated with biofilm formation; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (137 aa)
rcsDPhosphotransfer intermediate protein in two-component regulatory system with RcsBC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (890 aa)
rcsBDNA-binding response regulator in two-component regulatory system with RcsC and YojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (216 aa)
rcsCHybrid sensory kinase in two-component regulatory system with RcsB and YojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (933 aa)
crrGlucose-specific enzyme IIA component of PTS; Function experimentally demonstrated in the studied species; transporter. (169 aa)
gcvRDNA-binding transcriptional repressor, regulatory protein accessory to GcvA; Function experimentally demonstrated in the studied species; regulator. (190 aa)
luxSS-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
csrAPleiotropic regulatory protein for carbon source metabolism; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small [...] (61 aa)
rpoSRNA polymerase, sigma S (sigma 38) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
cyaAAdenylate cyclase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the adenylyl cyclase class-1 family. (848 aa)
oxyRDNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator; Belongs to the LysR transcriptional regulatory family. (305 aa)
gcvADNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator; Belongs to the LysR transcriptional regulatory family. (305 aa)
arcBHybrid sensory histidine kinase in two-component regulatory system with ArcA; Function experimentally demonstrated in the studied species; regulator. (778 aa)
crpDNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator. (210 aa)
envZSensory histidine kinase in two-component regulatory system with OmpR; Function experimentally demonstrated in the studied species; regulator. (450 aa)
ompRDNA-binding response regulator in two-component regulatory system with EnvZ; Function experimentally demonstrated in the studied species; regulator. (239 aa)
malPMaltodextrin phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (797 aa)
glgPGlycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (815 aa)
glgAGlycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (477 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. (431 aa)
yhjHEAL domain containing protein involved in flagellar function; Function experimentally demonstrated in the studied species; regulator. (255 aa)
bcsACellulose synthase, catalytic subunit; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose. (868 aa)
arcADNA-binding response regulator in two-component regulatory system with ArcB or CpxA; Function experimentally demonstrated in the studied species; regulator. (238 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
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