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mogA mogA thiI thiI moaA moaA moaB moaB moaC moaC moaD moaD moaE moaE moeB moeB ynjE ynjE trmU trmU tusE tusE sseA sseA iscS iscS tusB tusB tusC tusC tusD tusD tusA tusA thiS thiS thiF thiF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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mogAMolybdochelatase MogA, involved in Moco biosynthesis; Function experimentally demonstrated in the studied species; factor. (195 aa)
thiISulfurtransferase required for thiamine and 4-thiouridine biosynthesis; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa)
moaAMolybdopterin biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa)
moaBMolybdopterin biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (170 aa)
moaCMolybdopterin biosynthesis, protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa)
moaDMolybdopterin synthase, small subunit; Function experimentally demonstrated in the studied species; enzyme. (81 aa)
moaEMolybdopterin synthase, large subunit; Function experimentally demonstrated in the studied species; enzyme. (150 aa)
moeBMolybdopterin synthase sulfurylase; Function experimentally demonstrated in the studied species; enzyme. (249 aa)
ynjEPutative exported thiosulfate sulfur transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (435 aa)
trmUtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. (368 aa)
tusESubunit of enzyme for 2-thio modification of mnm5s2U of tRNA anticodon U; Part of a sulfur-relay system. (109 aa)
sseA3-mercaptopyruvate sulfurtransferase; Function experimentally demonstrated in the studied species; enzyme. (281 aa)
iscSCysteine desulfurase (tRNA sulfurtransferase), PLP-dependent; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate; Belongs to the class-V pyr [...] (404 aa)
tusBMethylsulfur transfer protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. (95 aa)
tusCMethylsulfur transfer protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. (119 aa)
tusDMethylsulfur transfer protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE. (128 aa)
tusASulfurtransferase; Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin. (81 aa)
thiSSulphur carrier protein; Function experimentally demonstrated in the studied species; carrier. (66 aa)
thiFThiamin (thiazole moiety) biosynthesis protein; Function experimentally demonstrated in the studied species; enzyme. (251 aa)
Your Current Organism:
Escherichia coli IAI39
NCBI taxonomy Id: 585057
Other names: E. coli IAI39
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