(38 nodes) RNA Polymerase II Transcription Termination network (Plasmodium knowlesi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PKH_080300	RNA-binding protein, putative. (837 aa)
	PKH_082910	Splicing factor, putative. (552 aa)
	PKH_092460	Small Nuclear ribonucleoprotein F, Putative. (86 aa)
	PKH_060650	Serine/arginine-rich splicing factor 4, putative. (495 aa)
	PKH_070720	Small nuclear ribonucleoprotein Sm D3. (116 aa)
	PKH_094570	Histone RNA hairpin-binding protein, putative. (314 aa)
	PKH_041020	ATP-dependent RNA helicase UAP56, putative. (472 aa)
	PKH_072540	RNA-binding protein, putative. (553 aa)
	PKH_051220	Cleavage and polyadenylation specificity factor subunit 2. (1278 aa)
	PKH_113330	RNA and export factor binding protein, putative. (153 aa)
	PKH_120570	Step II splicing factor, putative. (220 aa)
	PKH_050940	Polyribonucleotide 5'-hydroxyl-kinase Clp1, putative. (577 aa)
	PKH_092860	RNA-binding protein s1, putative. (156 aa)
	PKH_146710	THO complex subunit 2, putative. (2515 aa)
	PKH_020430	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (257 aa)
	PKH_112870	Cleavage stimulation factor subunit 1-like protein, putative. (525 aa)
	PKH_082050	Histone RNA hairpin-binding protein, putative. (285 aa)
	PKH_040770	Uncharacterized protein. (3751 aa)
	PKH_030250	RNA-binding protein, putative. (1014 aa)
	PKH_072110	Polyadenylate-binding protein 2, putative. (202 aa)
	PKH_143670	Pre-mRNA-processing factor 17, putative. (613 aa)
	PKH_110640	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative. (1142 aa)
	PKH_101380	SLBP_RNA_bind domain-containing protein. (363 aa)
	PKH_100560	Uncharacterized protein. (1246 aa)
	PKH_122660	RRM domain-containing protein. (513 aa)
	PKH_073120	CSTF domain-containing protein, putative. (820 aa)
	PKH_112370	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (637 aa)
	PKH_073200	Fip1 domain-containing protein. (271 aa)
	PKH_133440	Uncharacterized protein. (403 aa)
	PKH_126790	Cleavage and polyadenylation specificity factor subunit 3, putative. (938 aa)
	PKH_091720	Alternative splicing factor ASF-1, putative. (206 aa)
	PKH_101550	Serine/arginine-rich splicing factor 1, putative. (312 aa)
	PKH_123660	Splicing factor U2AF large subunit, putative. (865 aa)
	PKH_090380	DEAD/DEAH box helicase, putative. (1272 aa)
	PKH_113890	Pre-mRNA-splicing factor SLU7, putative. (440 aa)
	PKH_120370	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (96 aa)
	PKH_050870	Small nuclear ribonucleoprotein G. (83 aa)
	PKH_070980	SAP domain-containing protein. (306 aa)

Your Current Organism:

Plasmodium knowlesi

NCBI taxonomy Id: 5851
Other names: P. knowlesi strain H, Plasmodium knowlesi (STRAIN H), Plasmodium knowlesi H, Plasmodium knowlesi Malayan H, Plasmodium knowlesi strain H

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PKH_020430	PKH_030250	A0A384KMN1	A0A384KZ88	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	RNA-binding protein, putative.	0.688
PKH_020430	PKH_040770	A0A384KMN1	A0A384KYE3	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Uncharacterized protein.	0.676
PKH_020430	PKH_041020	A0A384KMN1	A0A384KI41	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	ATP-dependent RNA helicase UAP56, putative.	0.698
PKH_020430	PKH_050940	A0A384KMN1	A0A384KKR6	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Polyribonucleotide 5'-hydroxyl-kinase Clp1, putative.	0.811
PKH_020430	PKH_051220	A0A384KMN1	A0A384KJA2	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Cleavage and polyadenylation specificity factor subunit 2.	0.914
PKH_020430	PKH_060650	A0A384KMN1	A0A384KE18	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Serine/arginine-rich splicing factor 4, putative.	0.697
PKH_020430	PKH_070980	A0A384KMN1	B3L3D6	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	SAP domain-containing protein.	0.753
PKH_020430	PKH_072110	A0A384KMN1	A0A384KZZ7	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Polyadenylate-binding protein 2, putative.	0.748
PKH_020430	PKH_073120	A0A384KMN1	A0A384L8G1	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	CSTF domain-containing protein, putative.	0.887
PKH_020430	PKH_073200	A0A384KMN1	A0A384LA27	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Fip1 domain-containing protein.	0.973
PKH_020430	PKH_080300	A0A384KMN1	B3L3H4	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	RNA-binding protein, putative.	0.697
PKH_020430	PKH_090380	A0A384KMN1	A0A384LLV3	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	DEAD/DEAH box helicase, putative.	0.698
PKH_020430	PKH_091720	A0A384KMN1	A0A384LH68	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Alternative splicing factor ASF-1, putative.	0.741
PKH_020430	PKH_092860	A0A384KMN1	A0A384KL85	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	RNA-binding protein s1, putative.	0.748
PKH_020430	PKH_100560	A0A384KMN1	A0A384L7C6	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Uncharacterized protein.	0.863
PKH_020430	PKH_101550	A0A384KMN1	A0A384LK14	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Serine/arginine-rich splicing factor 1, putative.	0.741
PKH_020430	PKH_110640	A0A384KMN1	A0A384L4S1	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative.	0.733
PKH_020430	PKH_112370	A0A384KMN1	A0A384L8J4	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's.	0.836
PKH_020430	PKH_112870	A0A384KMN1	A0A384KQA2	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	Cleavage stimulation factor subunit 1-like protein, putative.	0.916
PKH_020430	PKH_113330	A0A384KMN1	A0A384KJV8	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	RNA and export factor binding protein, putative.	0.829

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