(18 nodes) Interconversion of nucleotide di- and triphosphates, and Pyruvate kinase network (Theileria annulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TA10915	Pyruvate kinase; Belongs to the pyruvate kinase family. (513 aa)
	TA08775	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. (523 aa)
	TA07740	Bis-(5' nucleosyl)-tetraphosphatase, putative. (151 aa)
	TA18255	Cytidine and deoxycytidylate deaminase family protein, putative. (183 aa)
	TA17785	Ham1-like protein, putative. (181 aa)
	TA05060	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (891 aa)
	TA04650	Deaminase, putative. (297 aa)
	TA11540	Pyruvate kinase, putative. (699 aa)
	TA11865	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity; Belongs to the adenylate kinase family. AK6 subfamily. (185 aa)
	TA12510	Thymidylate kinase, putative. (214 aa)
	TA13095	Nucleoside diphosphate kinase, putative; Belongs to the NDK family. (149 aa)
	TA13945	Guanylate kinase, putative. (196 aa)
	TA14600	UMP-CMP kinase, putative; Belongs to the adenylate kinase family. (188 aa)
	TA15425	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (565 aa)
	TA20975	Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative. (203 aa)
	TA03055	Adenylate kinase, putative; Belongs to the adenylate kinase family. (242 aa)
	TA06715	Ribonucleotide reductase R2 subunit or ribonucleoside-diphosphate reductase small chain, putative. (322 aa)
	TA09665	Ribonucleoside reductase, putative. (332 aa)

Your Current Organism:

Theileria annulata

NCBI taxonomy Id: 5874
Other names: T. annulata

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TA03055	TA05060	Q4UHG4	Q4UBQ2	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.980
TA03055	TA06715	Q4UHG4	Q4UHR4	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Ribonucleotide reductase R2 subunit or ribonucleoside-diphosphate reductase small chain, putative.	0.961
TA03055	TA08775	Q4UHG4	Q4U9G5	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.879
TA03055	TA09665	Q4UHG4	Q4UJ43	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Ribonucleoside reductase, putative.	0.961
TA03055	TA10915	Q4UHG4	Q4U977	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.933
TA03055	TA11540	Q4UHG4	Q4UDJ5	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Pyruvate kinase, putative.	0.933
TA03055	TA11865	Q4UHG4	Q4UDQ4	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity; Belongs to the adenylate kinase family. AK6 subfamily.	0.950
TA03055	TA12510	Q4UHG4	Q4UE21	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Thymidylate kinase, putative.	0.790
TA03055	TA13095	Q4UHG4	Q4UEC7	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Nucleoside diphosphate kinase, putative; Belongs to the NDK family.	0.985
TA03055	TA13945	Q4UHG4	Q4UET2	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Guanylate kinase, putative.	0.943
TA03055	TA14600	Q4UHG4	Q4UF48	Adenylate kinase, putative; Belongs to the adenylate kinase family.	UMP-CMP kinase, putative; Belongs to the adenylate kinase family.	0.779
TA03055	TA15425	Q4UHG4	Q4UFH6	Adenylate kinase, putative; Belongs to the adenylate kinase family.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.799
TA03055	TA17785	Q4UHG4	Q4UB88	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Ham1-like protein, putative.	0.425
TA03055	TA20975	Q4UHG4	Q4UGW1	Adenylate kinase, putative; Belongs to the adenylate kinase family.	Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative.	0.791
TA04650	TA05060	Q4UBY6	Q4UBQ2	Deaminase, putative.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.421
TA04650	TA08775	Q4UBY6	Q4U9G5	Deaminase, putative.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.930
TA04650	TA12510	Q4UBY6	Q4UE21	Deaminase, putative.	Thymidylate kinase, putative.	0.705
TA04650	TA18255	Q4UBY6	Q4UB02	Deaminase, putative.	Cytidine and deoxycytidylate deaminase family protein, putative.	0.998
TA04650	TA20975	Q4UBY6	Q4UGW1	Deaminase, putative.	Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative.	0.477
TA05060	TA03055	Q4UBQ2	Q4UHG4	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Adenylate kinase, putative; Belongs to the adenylate kinase family.	0.980