(41 nodes) Proteasome-mediated ubiquitin-dependent protein catabolic process network (Theileria annulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TA10110	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (239 aa)
	TA10125	Uncharacterized protein. (630 aa)
	TA10500	Heat-shock (HSP70 homologue) protein, putative; Belongs to the heat shock protein 70 family. (655 aa)
	TA10720	Heat shock protein (HSP90 homologue), putative. (913 aa)
	TA10875	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (220 aa)
	TA08845	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (2154 aa)
	TA08355	26S proteasome regulatory subunit, putative; Belongs to the proteasome subunit S1 family. (1041 aa)
	TA08210	26S proteasome regulatory subunit, putative. (425 aa)
	TA08080	VWFA domain-containing protein. (332 aa)
	TA07520	WD_REPEATS_REGION domain-containing protein. (591 aa)
	TA07380	26S proteasome (Regulatory) subunit, putative. (298 aa)
	TA17225	26s protease regulatory subunit, putative; Belongs to the AAA ATPase family. (396 aa)
	TA04855	Cell divison cycle CDC48 homologue, putative or transitional endoplasmic reticulum ATPase, putative. (905 aa)
	TA04025	CTLH domain-containing protein. (447 aa)
	TA03980	Ubiquitin-conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family. (168 aa)
	TA03810	SEP domain-containing protein. (211 aa)
	TA03425	Sulfur metabolism negative regulator, putative; Belongs to the SKP1 family. (172 aa)
	TA02555	26S proteasome regulatory subunit, putative. (278 aa)
	TA11460	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (209 aa)
	TA11615	E3 ubiquitin protein ligase. (685 aa)
	TA12235	Uncharacterized protein. (640 aa)
	TA12340	Ubiquitin-conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family. (162 aa)
	TA13670	Ubiquitin fusion degradation protein (UFD1 homologue), putative. (270 aa)
	TA15700	26S proteasome ATPase subunit (Rpt6A homologue), putative; Belongs to the AAA ATPase family. (393 aa)
	TA15835	RING-type domain-containing protein. (1745 aa)
	TA15910	Uncharacterized protein. (1337 aa)
	TA19965	Ubiquitin-related protein, putative. (1736 aa)
	TA19160	Ubiquitin regulatory protein, putative. (338 aa)
	TA19295	CLTH domain-containing protein. (234 aa)
	TA19515	Ubiquitin-protein ligase 1, putative. (4418 aa)
	TA21405	226S proteasome regulatory particle, putative; Belongs to the AAA ATPase family. (419 aa)
	TA20200	Proteasome subunit alpha type. (254 aa)
	TA06145	26S proteasome regulatory subunit, putative. (1105 aa)
	TA06255	26S proteasome subunit, putative; Belongs to the AAA ATPase family. (435 aa)
	TA06755	Ubiquitin conjugating enzyme, putative; Belongs to the ubiquitin-conjugating enzyme family. (197 aa)
	TA05765	Ubiquitination-mediated degradation component, putative. (1110 aa)
	TA05905	RING-type domain-containing protein. (1011 aa)
	TA05950	26S proteasome subunit 4, putative; Belongs to the AAA ATPase family. (438 aa)
	TA06130	DNA repair protein (RAD23 homologue), putative. (328 aa)
	TA06470	Chaperone protein (HSP90 homologue), putative. (988 aa)
	TA16520	Ubiquitin-fusion degradation pathway component, UFD1 homologue, putative. (321 aa)

Your Current Organism:

Theileria annulata

NCBI taxonomy Id: 5874
Other names: T. annulata

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TA02555	TA03425	Q4UD14	Q4UCL0	26S proteasome regulatory subunit, putative.	Sulfur metabolism negative regulator, putative; Belongs to the SKP1 family.	0.664
TA02555	TA03980	Q4UD14	Q4UCA9	26S proteasome regulatory subunit, putative.	Ubiquitin-conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family.	0.510
TA02555	TA04855	Q4UD14	Q4UBT9	26S proteasome regulatory subunit, putative.	Cell divison cycle CDC48 homologue, putative or transitional endoplasmic reticulum ATPase, putative.	0.732
TA02555	TA05950	Q4UD14	Q4UI30	26S proteasome regulatory subunit, putative.	26S proteasome subunit 4, putative; Belongs to the AAA ATPase family.	0.999
TA02555	TA06130	Q4UD14	Q4UI64	26S proteasome regulatory subunit, putative.	DNA repair protein (RAD23 homologue), putative.	0.901
TA02555	TA06145	Q4UD14	Q4UHP5	26S proteasome regulatory subunit, putative.	26S proteasome regulatory subunit, putative.	0.999
TA02555	TA06255	Q4UD14	Q4UHP7	26S proteasome regulatory subunit, putative.	26S proteasome subunit, putative; Belongs to the AAA ATPase family.	0.999
TA02555	TA06755	Q4UD14	Q4UHS2	26S proteasome regulatory subunit, putative.	Ubiquitin conjugating enzyme, putative; Belongs to the ubiquitin-conjugating enzyme family.	0.517
TA02555	TA07380	Q4UD14	Q4UA69	26S proteasome regulatory subunit, putative.	26S proteasome (Regulatory) subunit, putative.	0.999
TA02555	TA08080	Q4UD14	Q4U9U3	26S proteasome regulatory subunit, putative.	VWFA domain-containing protein.	0.999
TA02555	TA08210	Q4UD14	Q4U9R8	26S proteasome regulatory subunit, putative.	26S proteasome regulatory subunit, putative.	0.999
TA02555	TA08355	Q4UD14	Q4U9P2	26S proteasome regulatory subunit, putative.	26S proteasome regulatory subunit, putative; Belongs to the proteasome subunit S1 family.	0.999
TA02555	TA10875	Q4UD14	Q4U969	26S proteasome regulatory subunit, putative.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.999
TA02555	TA12340	Q4UD14	Q4UDY9	26S proteasome regulatory subunit, putative.	Ubiquitin-conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family.	0.510
TA02555	TA13670	Q4UD14	Q4UEN1	26S proteasome regulatory subunit, putative.	Ubiquitin fusion degradation protein (UFD1 homologue), putative.	0.615
TA02555	TA15700	Q4UD14	Q4UFM6	26S proteasome regulatory subunit, putative.	26S proteasome ATPase subunit (Rpt6A homologue), putative; Belongs to the AAA ATPase family.	0.999
TA02555	TA16520	Q4UD14	Q4UIX9	26S proteasome regulatory subunit, putative.	Ubiquitin-fusion degradation pathway component, UFD1 homologue, putative.	0.615
TA02555	TA17225	Q4UD14	Q4UAQ2	26S proteasome regulatory subunit, putative.	26s protease regulatory subunit, putative; Belongs to the AAA ATPase family.	0.999
TA02555	TA20200	Q4UD14	Q4UHB7	26S proteasome regulatory subunit, putative.	Proteasome subunit alpha type.	0.996
TA02555	TA21405	Q4UD14	Q4UGM6	26S proteasome regulatory subunit, putative.	226S proteasome regulatory particle, putative; Belongs to the AAA ATPase family.	0.999