STRINGSTRING
TA21475 TA21475 TA18320 TA18320 TA18370 TA18370 TA17345 TA17345 TA07290 TA07290 TA09185 TA09185 TA07345 TA07345 TA07365 TA07365 TA07639 TA07639 TA07680 TA07680 TA07840 TA07840 TA07845 TA07845 TA07975 TA07975 TA08020 TA08020 TA08070 TA08070 TA08125 TA08125 TA08255 TA08255 TA08265 TA08265 TA08295 TA08295 TA08380 TA08380 TA08755 TA08755 TA08790 TA08790 TA08895 TA08895 TA08900 TA08900 TA10875 TA10875 TA10820 TA10820 TA10610 TA10610 TA10535 TA10535 TA10290 TA10290 TA09740 TA09740 TA09515 TA09515 TA16885 TA16885 TA16710 TA16710 TA06645 TA06645 TA06565 TA06565 TA06550 TA06550 TA06455 TA06455 TA06335 TA06335 TA06290 TA06290 TA06270 TA06270 TA06230 TA06230 TA06155 TA06155 TA06105 TA06105 TA06040 TA06040 TA05875 TA05875 LSM5 LSM5 TA06995 TA06995 TA06950 TA06950 TA06865 TA06865 TA06835 TA06835 TA20170 TA20170 TA20200 TA20200 TA20305 TA20305 TA20935 TA20935 TA20995 TA20995 TA21000 TA21000 TA21090 TA21090 TA21415 TA21415 TA17880 TA17880 TA19535 TA19535 TA19315 TA19315 TA19155 TA19155 TA19065 TA19065 TA19000 TA19000 TA19925 TA19925 TA19770 TA19770 TA15875 TA15875 FEN1 FEN1 TA14800 TA14800 TA14695 TA14695 TA14640 TA14640 TA14475 TA14475 TA14260 TA14260 TA14155 TA14155 TA14075 TA14075 TA13565 TA13565 TA13400 TA13400 TA12830 TA12830 TA12715 TA12715 TA12660 TA12660 EIF6 EIF6 TA12145 TA12145 TA12125 TA12125 TA12040 TA12040 TA11715 TA11715 TA11620 TA11620 TA11615 TA11615 TA11440 TA11440 LSM3 LSM3 TA15495 TA15495 TA09995 TA09995 TA09855 TA09855 TA09850 TA09850 TA09840 TA09840 TA11350 TA11350 TA11345 TA11345 TA11330 TA11330 TA11215 TA11215 TA11075 TA11075 RPL5 RPL5 TA12910 TA12910 TA12690 TA12690 TA02685 TA02685 TA04860 TA04860 TA05395 TA05395 MCM7 MCM7 TA03785 TA03785 TA03880 TA03880 TA04215 TA04215 TA04270 TA04270 LSM8 LSM8 TA04575 TA04575 TA04590 TA04590 TA04595 TA04595 TA04735 TA04735 TA04740 TA04740 MED6 MED6 LSM4 LSM4 TA05010 TA05010 TA18270 TA18270 TA18630 TA18630 TA18790 TA18790 TA17840 TA17840 TA17855 TA17855
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TA21475Uncharacterized protein; Belongs to the CGI121/TPRKB family. (215 aa)
TA18320Proteasome subunit alpha type. (236 aa)
TA18370Sld5 domain-containing protein. (459 aa)
TA17345DNA helicase; Belongs to the MCM family. (916 aa)
TA07290Histone H2B; Belongs to the histone H2B family. (123 aa)
TA09185FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (490 aa)
TA07345Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (451 aa)
TA07365TFIIS N-terminal domain-containing protein. (335 aa)
TA07639WD_REPEATS_REGION domain-containing protein. (459 aa)
TA07680Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (363 aa)
TA07840Histone H3; Belongs to the histone H3 family. (136 aa)
TA07845Histone H2A; Belongs to the histone H2A family. (127 aa)
TA07975H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (174 aa)
TA08020Small nuclear ribonucleoprotein Sm D3. (118 aa)
TA08070Proteasome subunit alpha type. (276 aa)
TA08125CBFD_NFYB_HMF domain-containing protein. (182 aa)
TA08255DNA-binding chaperone, putative. (655 aa)
TA08265Histone H2B; Belongs to the histone H2B family. (107 aa)
TA08295Structural maintenance of chromosomes protein. (1266 aa)
TA0838060S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (182 aa)
TA08755ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (925 aa)
TA08790Uncharacterized protein. (1545 aa)
TA08895DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
TA08900Endonuclease (Xp-g/RAD2 homologue), putative. (899 aa)
TA10875Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (220 aa)
TA10820Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (226 aa)
TA10610RuvB-like helicase; Belongs to the RuvB family. (494 aa)
TA10535Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
TA10290Uncharacterized protein. (229 aa)
TA09740Uncharacterized protein. (752 aa)
TA09515U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (151 aa)
TA16885Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (225 aa)
TA16710General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (645 aa)
TA06645Nuclear cap-binding protein subunit 2. (177 aa)
TA06565Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (125 aa)
TA06550Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (239 aa)
TA06455SANT domain-containing protein. (665 aa)
TA06335Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (271 aa)
TA06290DNA polymerase. (1088 aa)
TA06270Uncharacterized protein. (493 aa)
TA06230Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (138 aa)
TA06155Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (270 aa)
TA06105SNF2-family protein (Chromodomain-helicase-DNA-binding protein 1 homologue), putative. (1816 aa)
TA06040H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (197 aa)
TA0587560S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (512 aa)
LSM5U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (90 aa)
TA06995Transcriptional adaptor (ADA2 homologue), putative. (1146 aa)
TA06950Chromatin assembly factor subunit, putative. (463 aa)
TA06865GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (211 aa)
TA06835Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (452 aa)
TA20170HAP-family transcription factor, putative. (251 aa)
TA20200Proteasome subunit alpha type. (254 aa)
TA20305Transcription elongation factor, putative. (418 aa)
TA20935TFIIS N-terminal domain-containing protein. (652 aa)
TA20995tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (290 aa)
TA21000Small nuclear ribonucleoprotein f, putative. (91 aa)
TA21090Uncharacterized protein. (147 aa)
TA21415Structural maintenance of chromosomes protein. (1299 aa)
TA17880SWI3-like protein, putative. (588 aa)
TA19535DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (145 aa)
TA19315Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (212 aa)
TA19155Rad3-like DNA helicase-related, putative. (894 aa)
TA19065Chromatin assembly factor 1 protein, putative. (371 aa)
TA19000Transcriptional adaptor2-related protein, putative. (610 aa)
TA19925Jumonji family zinc finger protein, putative. (709 aa)
TA19770Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (512 aa)
TA15875Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (239 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (506 aa)
TA14800Small nuclear ribonucleoprotein Sm D2. (106 aa)
TA14695Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (550 aa)
TA14640Small nuclear ribonucleoprotein G. (82 aa)
TA14475WD_REPEATS_REGION domain-containing protein. (451 aa)
TA14260KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (355 aa)
TA14155Histone H2A; Belongs to the histone H2A family. (152 aa)
TA14075Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
TA13565ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (875 aa)
TA13400Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (346 aa)
TA12830Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (286 aa)
TA12715Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (416 aa)
TA12660Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (382 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (249 aa)
TA12145RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (927 aa)
TA12125Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (597 aa)
TA12040Importin N-terminal domain-containing protein. (1060 aa)
TA11715Importin-like protein, putative. (1281 aa)
TA11620Cleavage and polyadenylation specificity factor subunit 2. (830 aa)
TA11615E3 ubiquitin protein ligase. (685 aa)
TA11440Structural maintenance of chromosomes protein. (1348 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (94 aa)
TA15495Replication protein A subunit. (625 aa)
TA09995Helicase, putative. (951 aa)
TA09855Microtubule-associated protein (YTM1 homologue), putative. (433 aa)
TA09850Uncharacterized protein. (1083 aa)
TA09840DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2210 aa)
TA11350Proteasome subunit alpha type. (254 aa)
TA11345Proteasome subunit alpha type. (236 aa)
TA11330Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (920 aa)
TA11215Uncharacterized protein. (250 aa)
TA11075Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (129 aa)
RPL560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (306 aa)
TA12910Histone h3-like, putative. (324 aa)
TA12690Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (446 aa)
TA02685Chromodomain protein (HP1-like), putative. (341 aa)
TA04860Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (438 aa)
TA05395Histone H3; Belongs to the histone H3 family. (136 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (827 aa)
TA03785Proteasome subunit alpha type. (256 aa)
TA03880Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (128 aa)
TA04215Xpo1 domain-containing protein. (1446 aa)
TA04270Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (91 aa)
LSM8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (113 aa)
TA04575RuvB-like helicase; Belongs to the RuvB family. (492 aa)
TA04590Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (274 aa)
TA04595Proteasome subunit beta; Belongs to the peptidase T1B family. (229 aa)
TA04735High-mobility-group (HMG) protein, putative. (94 aa)
TA04740Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (681 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (214 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (105 aa)
TA05010Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1182 aa)
TA18270Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (659 aa)
TA18630Replication factor C subunit 1. (961 aa)
TA18790Chl1 protein, putative. (829 aa)
TA17840Protein MAK16 homolog; Belongs to the MAK16 family. (238 aa)
TA17855tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family. (463 aa)
Your Current Organism:
Theileria annulata
NCBI taxonomy Id: 5874
Other names: T. annulata
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