(19 nodes) Activation of the pre-replicative complex network (Theileria annulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TA09840	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2210 aa)
	TA08800	DNA replication protein (MCM homologue), putative; Belongs to the MCM family. (945 aa)
	TA08125	CBFD_NFYB_HMF domain-containing protein. (182 aa)
	TA07425	Zf-primase domain-containing protein. (438 aa)
	TA07375	J domain-containing protein. (230 aa)
	TA18575	Uncharacterized protein. (129 aa)
	TA18570	Hypothtical protein. (227 aa)
	TA04740	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (681 aa)
	TA04485	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (510 aa)
	TA03330	DNA polymerase. (1074 aa)
	TA03325	Uncharacterized protein. (145 aa)
	TA15495	Replication protein A subunit. (625 aa)
	TA12280	DNA_pol_E_B domain-containing protein. (627 aa)
	TA12985	Uncharacterized protein. (418 aa)
	TA13200	Replication factor A-related protein, putative. (466 aa)
	TA14555	CDC6-like ATPase, putative. (458 aa)
	TA15420	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (397 aa)
	TA15035	Uncharacterized protein. (2184 aa)
	TA19765	Origin recognition complex-like protein, putative. (509 aa)

Your Current Organism:

Theileria annulata

NCBI taxonomy Id: 5874
Other names: T. annulata

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TA03325	TA03330	Q4UCM9	Q4UCM8	Uncharacterized protein.	DNA polymerase.	0.526
TA03325	TA04485	Q4UCM9	Q4UC16	Uncharacterized protein.	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.983
TA03325	TA04740	Q4UCM9	Q4UBW0	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.812
TA03325	TA07425	Q4UCM9	Q4UA61	Uncharacterized protein.	Zf-primase domain-containing protein.	0.898
TA03325	TA08125	Q4UCM9	Q4U9T4	Uncharacterized protein.	CBFD_NFYB_HMF domain-containing protein.	0.905
TA03325	TA08800	Q4UCM9	Q4U9G0	Uncharacterized protein.	DNA replication protein (MCM homologue), putative; Belongs to the MCM family.	0.903
TA03325	TA09840	Q4UCM9	Q4U8N2	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.934
TA03325	TA12280	Q4UCM9	Q4UDY0	Uncharacterized protein.	DNA_pol_E_B domain-containing protein.	0.948
TA03325	TA12985	Q4UCM9	Q4UEA6	Uncharacterized protein.	Uncharacterized protein.	0.708
TA03325	TA13200	Q4UCM9	Q4UEE5	Uncharacterized protein.	Replication factor A-related protein, putative.	0.756
TA03325	TA14555	Q4UCM9	Q4UF40	Uncharacterized protein.	CDC6-like ATPase, putative.	0.812
TA03325	TA15035	Q4UCM9	Q4UFU6	Uncharacterized protein.	Uncharacterized protein.	0.731
TA03325	TA15420	Q4UCM9	Q4UFH5	Uncharacterized protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.973
TA03325	TA15495	Q4UCM9	Q4UDF8	Uncharacterized protein.	Replication protein A subunit.	0.756
TA03325	TA18570	Q4UCM9	Q4UBH4	Uncharacterized protein.	Hypothtical protein.	0.945
TA03325	TA18575	Q4UCM9	Q4UBH3	Uncharacterized protein.	Uncharacterized protein.	0.945
TA03325	TA19765	Q4UCM9	Q4UFZ9	Uncharacterized protein.	Origin recognition complex-like protein, putative.	0.758
TA03330	TA03325	Q4UCM8	Q4UCM9	DNA polymerase.	Uncharacterized protein.	0.526
TA03330	TA04485	Q4UCM8	Q4UC16	DNA polymerase.	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.983
TA03330	TA04740	Q4UCM8	Q4UBW0	DNA polymerase.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.812