(166 nodes) Processing of Capped Intron-Containing Pre-mRNA network (Theileria annulata)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TA09515	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (151 aa)
	TA09585	Uncharacterized protein. (213 aa)
	TA09605	Pre-mRNA splicing protein (Prp18 homologue), putative. (410 aa)
	TA09650	Pinin_SDK_memA domain-containing protein. (292 aa)
	TA09635	Uncharacterized protein. (426 aa)
	TA10195	DNA-directed RNA polymerase, subunit (RPB5 homologue), putative. (205 aa)
	TA10200	DUF2040 domain-containing protein. (260 aa)
	TA10585	RRM domain-containing protein. (1139 aa)
	TA10155	Matrin-type domain-containing protein. (893 aa)
	TA10170	Uncharacterized protein. (746 aa)
	TA10260	Nucleoporin, putative. (1033 aa)
	TA10430	Uncharacterized protein. (284 aa)
	TA10440	Uncharacterized protein. (561 aa)
	TA10560	WD_REPEATS_REGION domain-containing protein. (407 aa)
	TA10595	WD_REPEATS_REGION domain-containing protein. (521 aa)
	TA10820	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (226 aa)
	TA09040	Uncharacterized protein. (330 aa)
	TA08945	RNA binding protein, putative. (479 aa)
	TA08570	RNA polymerase common subunit (Rpb6 homologue), putative. (153 aa)
	TA08230	Symplekin_C domain-containing protein. (1337 aa)
	TA08190	SLBP_RNA_bind domain-containing protein. (177 aa)
	TA08155	U1-type domain-containing protein. (261 aa)
	TA08040	WD_REPEATS_REGION domain-containing protein. (571 aa)
	TA08030	Microfibrillar-associated protein, putative. (431 aa)
	TA08020	Small nuclear ribonucleoprotein Sm D3. (118 aa)
	TA07965	U4/U6-associated splicing factor, putative. (603 aa)
	TA07925	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1223 aa)
	TA07860	Splicing factor (Hs SLU7 homologue), putative. (387 aa)
	TA07830	Uncharacterized protein. (556 aa)
	TA07805	Splicing factor, putative. (269 aa)
	TA07525	DEAD-family helicase, putative; Belongs to the DEAD box helicase family. (757 aa)
	TA07515	Pumilio-family RNA-binding protein, putative. (830 aa)
	TA07370	Spm1 homologue, putative. (350 aa)
	TA07195	Uncharacterized protein. (247 aa)
	TA07140	Splicing factor 3b subunit, putative. (1340 aa)
	TA09375	U5 snRNP subunit, putative. (1269 aa)
	TA09305	U5 snRNP-specific subunit, putative. (309 aa)
	TA17245	Splicing factor, putative. (380 aa)
	TA18375	Uncharacterized protein. (941 aa)
	TA18361	Uncharacterized protein. (303 aa)
	TA18360	DUF1604 domain-containing protein. (269 aa)
	TA18105	Uncharacterized protein. (730 aa)
	TA18065	Uncharacterized protein. (144 aa)
	TA18045	U5 small nuclear ribonucleoprotein-specific helicase, putative. (2248 aa)
	TA18000	RNA-binding protein, putative. (959 aa)
	TA18785	Sde2_N_Ubi domain-containing protein. (248 aa)
	TA18695	Ubiquitin-like protein, putative. (76 aa)
	TA18610	Cold shock protein, putative. (95 aa)
	TA09710	Uncharacterized protein. (732 aa)
	TA18560	Uncharacterized protein. (215 aa)
	TA05230	Cleavage and polyadenylation specificty factor, subunit, putative. (1282 aa)
	TA05085	RNA helicase, putative. (976 aa)
	TA04630	Uncharacterized protein. (515 aa)
	TA04540	Spliceosome-associated protein, putative. (706 aa)
	LSM8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (113 aa)
	TA04320	DEAD-box family helicase, putative. (1001 aa)
	TA04270	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (91 aa)
	TA04190	DEAD-box family helicase, putative. (451 aa)
	TA04070	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (175 aa)
	TA03990	RRM domain-containing protein. (164 aa)
	TA03790	U2 snRNP auxiliary factor, putative. (236 aa)
	TA03780	Splicing factor (PRP8 homologue), putative. (2786 aa)
	TA03635	PRP38 family, putative. (193 aa)
	TA03440	RNA-binding protein, putative. (146 aa)
	TA03395	Uncharacterized protein. (527 aa)
	TA03380	Splicing factor subunit, putative. (1108 aa)
	TA03320	Snrnp splicing factor (U2AF), putative. (486 aa)
	TA03235	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1678 aa)
	TA05505	SAP domain-containing protein. (248 aa)
	TA05465	Uncharacterized protein. (2594 aa)
	TA05355	Uncharacterized protein. (1747 aa)
	TA03875	RNA poly(A)-binding protein, putative. (176 aa)
	TA03820	Uncharacterized protein. (338 aa)
	TA03430	Fumarate hydratase class I, putative. (622 aa)
	TA03375	Spliceosome-associated factor, putative. (712 aa)
	TA02600	U1 snRNP protein, putative. (346 aa)
	TA02605	RED_N domain-containing protein. (393 aa)
	TA02635	DNA-directed RNA polymerase II, putative. (124 aa)
	TA02675	PUB domain-containing protein. (468 aa)
	TA09690	Cell-cycle-control protein (Translation regulation), putative. (594 aa)
	TA11480	SfiI-subtelomeric related protein family member, putative. (444 aa)
	TA12750	SLBP_RNA_bind domain-containing protein. (380 aa)
	TA14065	RNA and export factor binding protein, putative. (188 aa)
	TA11620	Cleavage and polyadenylation specificity factor subunit 2. (830 aa)
	TA11730	PHF5-like zinc-finger protein, putative. (113 aa)
	TA11880	DNA-directed RNA polymerase 2 subunit, putative. (167 aa)
	TA11970	G10 protein, putative. (148 aa)
	TA12070	Nkap_C domain-containing protein. (241 aa)
	TA12495	RNA helicase, putative. (620 aa)
	TA12505	Uncharacterized protein. (678 aa)
	TA12735	RNA polymerase 16kd subunit, RPB4-like, putative. (130 aa)
	TA12740	Spm1 (Nucleoporin) protein. (893 aa)
	TA12755	Small nuclear ribonucleoprotein associated protein b, putative. (155 aa)
	TA12780	Splicing factor, putative. (369 aa)
	TA12835	Splicing factor 3b subunit 4, putative. (290 aa)
	TA12855	U1/2 small nuclear ribonucleoprotein, putative. (206 aa)
	TA12905	Splicing factor 3 subunit 1, putative. (486 aa)
	TA13015	Uncharacterized protein. (307 aa)
	TA13035	Pre-mRNA splicing factor (PRP17 homologue), putative. (693 aa)
	TA13050	DUF1716 domain-containing protein. (496 aa)
	TA13380	RNA processing protein (Crooked neck family), putative. (657 aa)
	TA13415	Splicing factor subunit; Belongs to the SF3B5 family. (94 aa)
	TA13480	DNAJ-like sec63 homologue, putative. (656 aa)
	TA13585	Chromatin-binding protein, putative. (470 aa)
	TA13605	Uncharacterized protein. (314 aa)
	TA13610	ATP-dependent RNA helicase, putative. (1027 aa)
	TA13725	RNA binding protein, putative. (122 aa)
	TA13760	U1 small nuclear ribonucleoprotein 70 kDa, putative. (227 aa)
	TA13975	Peptidyl-prolyl cis-trans isomerase, putative. (515 aa)
	TA14045	U4/U6 snRNP-associated protein, putative. (469 aa)
	TA14055	Cyclophilin, putative. (426 aa)
	TA14100	Uncharacterized protein. (287 aa)
	TA14280	Splicing factor 3a subunit 2, putative. (241 aa)
	TA14420	Cleavage stimulation factor subunit 1, putative. (345 aa)
	TA14630	Uncharacterized protein. (208 aa)
	TA14640	Small nuclear ribonucleoprotein G. (82 aa)
	TA14800	Small nuclear ribonucleoprotein Sm D2. (106 aa)
	TA14900	CPSF (Cleavage and polyadenylation specific factor), subunit A, putative. (1641 aa)
	TA14940	Uncharacterized protein. (307 aa)
	TA15100	Isy1-like splicing family, putative. (194 aa)
	TA15135	FHA domain-containing protein. (211 aa)
	TA15330	RRM domain-containing protein. (416 aa)
	TA15335	Ubiquitin carboxyl-terminal hydrolase, putative. (578 aa)
	TA15640	Uncharacterized protein. (89 aa)
	TA15645	Uncharacterized protein. (94 aa)
	TA15655	C3H1-type domain-containing protein. (238 aa)
	TA19560	PA14 domain-containing protein. (999 aa)
	TA19735	DNA-directed RNA polymerase ii, putative. (354 aa)
	TA19770	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (512 aa)
	TA20005	Rna-processing protein, putative. (826 aa)
	TA19015	Suf domain-containing protein. (929 aa)
	TA19055	SONA homologue, putative. (346 aa)
	TA19400	Uncharacterized protein. (502 aa)
	TA19500	DNA-directed RNA polymerase ii, putative. (175 aa)
	TA19535	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (145 aa)
	TA19570	RNA-binding protein, putative. (292 aa)
	TA21325	Serine/threonine protein kinase, putative. (766 aa)
	TA21175	Rna-binding protein, putative. (84 aa)
	TA21000	Small nuclear ribonucleoprotein f, putative. (91 aa)
	TA20895	Uncharacterized protein. (394 aa)
	TA20795	MIF4G_like_2 domain-containing protein. (971 aa)
	TA20625	U4/u6 small nuclear ribonucleoprotein, putative. (544 aa)
	TA20400	Cwf21 domain-containing protein. (294 aa)
	TA20210	RNA-binding protein, putative. (1024 aa)
	TA20195	Uncharacterized protein. (826 aa)
	TA20145	Splicing factor, putative. (425 aa)
	TA20115	DUF3546 domain-containing protein. (276 aa)
	TA20110	C2H2-type domain-containing protein. (291 aa)
	TA03090	Uncharacterized protein. (282 aa)
	TA03020	DEAD-box family helicase, putative. (945 aa)
	TA03015	U5 snRNP-specific component (DIM1 homologue), putative. (196 aa)
	TA06670	Uncharacterized protein. (514 aa)
	TA05710	Pre-mRNA splicing factor (U5 snRNP-associated), putative. (1022 aa)
	TA05795	Uncharacterized protein. (352 aa)
	TA05805	Cyclophilin peptidyl-prolyl cis-trans isomerase protein, putative. (613 aa)
	TA05865	RNA binding protein, putative. (373 aa)
	TA06035	RNA binding protein, putative. (338 aa)
	TA06100	Splicing factor (SR protein), putative. (341 aa)
	TA06270	Uncharacterized protein. (493 aa)
	TA06645	Nuclear cap-binding protein subunit 2. (177 aa)
	TA16855	DEAD-box family helicase, putative. (729 aa)
	TA17065	Myb-like DNA binding protein (CDC5 homologue), putative. (707 aa)
	TA17085	WW domain-containing protein. (348 aa)
	TA16260	Cir_N domain-containing protein. (217 aa)
	TA16335	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (205 aa)
	TA16690	CCHC-type domain-containing protein. (327 aa)

Your Current Organism:

Theileria annulata

NCBI taxonomy Id: 5874
Other names: T. annulata

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LSM8	TA02600	Q4UC24	Q4UD23	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	U1 snRNP protein, putative.	0.798
LSM8	TA02605	Q4UC24	Q4UD24	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	RED_N domain-containing protein.	0.532
LSM8	TA03015	Q4UC24	Q4UHH2	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	U5 snRNP-specific component (DIM1 homologue), putative.	0.977
LSM8	TA03375	Q4UC24	Q4UCY7	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Spliceosome-associated factor, putative.	0.821
LSM8	TA03380	Q4UC24	Q4UCL9	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Splicing factor subunit, putative.	0.870
LSM8	TA03395	Q4UC24	Q4UCL6	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.526
LSM8	TA03430	Q4UC24	Q4UCY6	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Fumarate hydratase class I, putative.	0.821
LSM8	TA03635	Q4UC24	Q4UCH1	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	PRP38 family, putative.	0.710
LSM8	TA03780	Q4UC24	Q4UCE6	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Splicing factor (PRP8 homologue), putative.	0.996
LSM8	TA04070	Q4UC24	Q4UC89	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.492
LSM8	TA04190	Q4UC24	Q4UC68	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	DEAD-box family helicase, putative.	0.481
LSM8	TA04270	Q4UC24	Q4UC53	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.991
LSM8	TA04540	Q4UC24	Q4UC05	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Spliceosome-associated protein, putative.	0.851
LSM8	TA05085	Q4UC24	Q4UBP8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	RNA helicase, putative.	0.416
LSM8	TA05710	Q4UC24	Q4UHY6	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Pre-mRNA splicing factor (U5 snRNP-associated), putative.	0.996
LSM8	TA06645	Q4UC24	Q4UIF7	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Nuclear cap-binding protein subunit 2.	0.682
LSM8	TA07140	Q4UC24	Q4UAB5	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Splicing factor 3b subunit, putative.	0.878
LSM8	TA07195	Q4UC24	Q4UAA3	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.783
LSM8	TA07525	Q4UC24	Q4UA43	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	DEAD-family helicase, putative; Belongs to the DEAD box helicase family.	0.734
LSM8	TA07805	Q4UC24	Q4U9Z3	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Splicing factor, putative.	0.627