(77 nodes) Biosynthesis of secondary metabolites network (Theileria annulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	TA11070	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (410 aa)
	TA11125	Mannose-6 phosphate isomerase, putative. (451 aa)
	TA09885	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (321 aa)
	TA10340	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (454 aa)
	TA10425	Enolase, putative. (442 aa)
	TA10465	Phosphoglycerate mutase, putative. (273 aa)
	TA10540	Triosephosphate isomerase. (371 aa)
	TA10625	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (329 aa)
	TA10850	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (459 aa)
	TA10915	Pyruvate kinase; Belongs to the pyruvate kinase family. (513 aa)
	TA08590	Triosephosphate isomerase. (329 aa)
	TA08565	LNS2 domain-containing protein. (594 aa)
	TA08530	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (422 aa)
	TA08145	Glyceraldehyde-3-phosphate dehydrogenase. (339 aa)
	TA07535	Prenyltransferase (Protoheme farnesyltransferase), putative. (326 aa)
	TA07295	Acetyl-coenzyme A synthetase. (681 aa)
	TA17300	Phosphatidate cytidylyltransferase; Belongs to the CDS family. (458 aa)
	TA17400	Farnesyl pyrophosphate synthetase, putative; Belongs to the FPP/GGPP synthase family. (384 aa)
	TA18170	Adenylosuccinate lyase, putative. (407 aa)
	TA18100	Malate:quinone oxidoreductase, putative. (493 aa)
	TA17980	U6 snrna-associated sm-like protein, putative. (87 aa)
	TA17925	Fad-dependent glycerol-3-phosphate dehydrogenase, putative. (615 aa)
	TA17870	Protein farnesyltransferase alpha subunit, putative. (306 aa)
	TA17670	LytB protein, putative. (318 aa)
	TA18840	Synaptic glycoprotein sc2, putative. (296 aa)
	TA18725	Ribose 5-phosphate epimerase, putative. (240 aa)
	TA18480	Cox15 homolog, putative. (425 aa)
	TA05220	Glucose-6-phosphate-1-dehydrogenase, putative. (878 aa)
	TA04455	Alkyl transferase; Belongs to the UPP synthase family. (205 aa)
	TA04155	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. (210 aa)
	TA04045	Glucose-6-phosphate isomerase; Belongs to the GPI family. (560 aa)
	TA03505	Prenyl transferase, putative; Belongs to the FPP/GGPP synthase family. (468 aa)
	TA03455	Succinate dehydrogenase (Flavoprotein) subunit, putative. (592 aa)
	TA03445	Dihydrolipoyl dehydrogenase. (451 aa)
	TA03405	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (511 aa)
	TA05275	2-oxoglutarate dehydrogenase E1 component, putative. (1021 aa)
	TA03430	Fumarate hydratase class I, putative. (622 aa)
	TA02505	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative. (439 aa)
	TA12970	Aspartate aminotransferase, cytoplasmic, putative. (412 aa)
	TA14290	1-deoxy-D-xylulose 5-phosphate reducto-isomerase, putative. (442 aa)
	TA11540	Pyruvate kinase, putative. (699 aa)
	TA11865	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity; Belongs to the adenylate kinase family. AK6 subfamily. (185 aa)
	TA12055	Uncharacterized protein. (174 aa)
	TA13095	Nucleoside diphosphate kinase, putative; Belongs to the NDK family. (149 aa)
	TA13375	Diacylglycerol kinase. (391 aa)
	TA14095	G domain-containing protein. (620 aa)
	TA14300	GDP-mannose pyrophosphorylase, putative. (389 aa)
	TA14450	Citrate synthase; Belongs to the citrate synthase family. (673 aa)
	TA14455	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase, putative. (808 aa)
	TA15255	Farnesyltransferase beta subunit, putative. (536 aa)
	TA15530	Glyceraldehyde 3-phosphate dehydrogenase, putative; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
	TA15870	Metallo-protease, putative. (458 aa)
	TA15890	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (438 aa)
	TA15895	Metallo-protease, putative. (447 aa)
	TA19800	Phosphotransferase. (485 aa)
	TA19810	Phosphotransferase. (485 aa)
	TA20060	Fructose-bisphosphate aldolase 2, putative. (377 aa)
	TA19350	6-phosphogluconate dehydrogenase, putative. (443 aa)
	TA19430	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (277 aa)
	TA19690	2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). (457 aa)
	TA21330	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (380 aa)
	TA20940	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (503 aa)
	TA20750	Trna delta (2)-isopentenylpyrophosphate transferase, putative; Belongs to the IPP transferase family. (337 aa)
	TA20635	Glycine cleavage complex t-protein, putative. (672 aa)
	TA20590	Phosphoenolpyruvate carboxykinase, putative. (580 aa)
	TA20470	1-deoxy-D-xylulose 5-phosphate synthase, putative. (761 aa)
	TA20125	Trehalose-6-phosphate synthase. (1091 aa)
	TA03055	Adenylate kinase, putative; Belongs to the adenylate kinase family. (242 aa)
	TA02815	Succinyl-coA ligase, subunit, putative. (433 aa)
	TA06725	Glutamyl-tRNA synthetase, putative; Belongs to the class-I aminoacyl-tRNA synthetase family. (542 aa)
	TA07020	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (248 aa)
	TA06600	Transketolase subunit, putative. (373 aa)
	TA06655	Phosphoglycerate kinase. (417 aa)
	TA16730	Phosphoribosyl pyrophosphate synthetase, putative. (325 aa)
	TA17020	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (929 aa)
	TA17035	Glutamyl-tRNA synthetase, putative; Belongs to the class-I aminoacyl-tRNA synthetase family. (726 aa)
	TA09530	Ethanolamine phosphotransferase, putative; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (404 aa)

Your Current Organism:

Theileria annulata

NCBI taxonomy Id: 5874
Other names: T. annulata

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TA02505	TA04155	Q4UD04	Q4UC75	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative.	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.	0.671
TA02505	TA10425	Q4UD04	Q4U8Y7	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative.	Enolase, putative.	0.406
TA02505	TA13095	Q4UD04	Q4UEC7	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative.	Nucleoside diphosphate kinase, putative; Belongs to the NDK family.	0.567
TA02505	TA14290	Q4UD04	Q4UDD7	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative.	1-deoxy-D-xylulose 5-phosphate reducto-isomerase, putative.	0.973
TA02505	TA20590	Q4UD04	Q4UH39	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative.	Phosphoenolpyruvate carboxykinase, putative.	0.456
TA02815	TA03055	Q4UHL1	Q4UHG4	Succinyl-coA ligase, subunit, putative.	Adenylate kinase, putative; Belongs to the adenylate kinase family.	0.535
TA02815	TA03405	Q4UHL1	Q4UCL4	Succinyl-coA ligase, subunit, putative.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.666
TA02815	TA03445	Q4UHL1	Q4UCK8	Succinyl-coA ligase, subunit, putative.	Dihydrolipoyl dehydrogenase.	0.954
TA02815	TA03455	Q4UHL1	Q4UCK6	Succinyl-coA ligase, subunit, putative.	Succinate dehydrogenase (Flavoprotein) subunit, putative.	0.997
TA02815	TA04045	Q4UHL1	Q4UC94	Succinyl-coA ligase, subunit, putative.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.713
TA02815	TA05220	Q4UHL1	Q4UBM4	Succinyl-coA ligase, subunit, putative.	Glucose-6-phosphate-1-dehydrogenase, putative.	0.679
TA02815	TA05275	Q4UHL1	Q4UCU9	Succinyl-coA ligase, subunit, putative.	2-oxoglutarate dehydrogenase E1 component, putative.	0.991
TA02815	TA06600	Q4UHL1	Q4UIE9	Succinyl-coA ligase, subunit, putative.	Transketolase subunit, putative.	0.837
TA02815	TA06655	Q4UHL1	Q4UIF9	Succinyl-coA ligase, subunit, putative.	Phosphoglycerate kinase.	0.719
TA02815	TA07295	Q4UHL1	Q4UA86	Succinyl-coA ligase, subunit, putative.	Acetyl-coenzyme A synthetase.	0.943
TA02815	TA07535	Q4UHL1	Q4UA41	Succinyl-coA ligase, subunit, putative.	Prenyltransferase (Protoheme farnesyltransferase), putative.	0.538
TA02815	TA08145	Q4UHL1	Q4U9T0	Succinyl-coA ligase, subunit, putative.	Glyceraldehyde-3-phosphate dehydrogenase.	0.544
TA02815	TA08530	Q4UHL1	Q4U9K9	Succinyl-coA ligase, subunit, putative.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.948
TA02815	TA08590	Q4UHL1	Q4U9J9	Succinyl-coA ligase, subunit, putative.	Triosephosphate isomerase.	0.543
TA02815	TA10340	Q4UHL1	Q4U8X2	Succinyl-coA ligase, subunit, putative.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.789