STRINGSTRING
SES48502.1 SES48502.1 SES48528.1 SES48528.1 SES48532.1 SES48532.1 SES48536.1 SES48536.1 SES49522.1 SES49522.1 SES49659.1 SES49659.1 SES49661.1 SES49661.1 SES49710.1 SES49710.1 SES49722.1 SES49722.1 SES49743.1 SES49743.1 SES49746.1 SES49746.1 SES49748.1 SES49748.1 SES49751.1 SES49751.1 SES49755.1 SES49755.1 SES49758.1 SES49758.1 SES49760.1 SES49760.1 SES49766.1 SES49766.1 SES49768.1 SES49768.1 prs prs SER64347.1 SER64347.1 SER64875.1 SER64875.1 leuD leuD leuC leuC SER69252.1 SER69252.1 SER69322.1 SER69322.1 leuB leuB ilvC ilvC SER69641.1 SER69641.1 SER69679.1 SER69679.1 ilvD ilvD SER70500.1 SER70500.1 SER72451.1 SER72451.1 SER75054.1 SER75054.1 pdhA pdhA SER75115.1 SER75115.1 SER75137.1 SER75137.1 SER75786.1 SER75786.1 SER76205.1 SER76205.1 SER77453.1 SER77453.1 SER77934.1 SER77934.1 SER78250.1 SER78250.1 SER80727.1 SER80727.1 SER82136.1 SER82136.1 SER82169.1 SER82169.1 SER89901.1 SER89901.1 SER89928.1 SER89928.1 SER91487.1 SER91487.1 SER93631.1 SER93631.1 SER94087.1 SER94087.1 SER94111.1 SER94111.1 SER97589.1 SER97589.1 SER97622.1 SER97622.1 SES00163.1 SES00163.1 SES00188.1 SES00188.1 SES00232.1 SES00232.1 SES00256.1 SES00256.1 SES00286.1 SES00286.1 SES00315.1 SES00315.1 SES07417.1 SES07417.1 SES08032.1 SES08032.1 SES08156.1 SES08156.1 SES08184.1 SES08184.1 SES08383.1 SES08383.1 SES08632.1 SES08632.1 SES08998.1 SES08998.1 SES10934.1 SES10934.1 SES11816.1 SES11816.1 SES12400.1 SES12400.1 SES12644.1 SES12644.1 SES12787.1 SES12787.1 leuA leuA SES14898.1 SES14898.1 SES14914.1 SES14914.1 SES14931.1 SES14931.1 SES14944.1 SES14944.1 SES14960.1 SES14960.1 SES14976.1 SES14976.1 SES14991.1 SES14991.1 SES15010.1 SES15010.1 SES15028.1 SES15028.1 SES15730.1 SES15730.1 SES16690.1 SES16690.1 acpP acpP fabH fabH SES16759.1 SES16759.1 SES16867.1 SES16867.1 SES23693.1 SES23693.1 SES23940.1 SES23940.1 SES23961.1 SES23961.1 ppc ppc SES32042.1 SES32042.1 SES32678.1 SES32678.1 acsA acsA SES33807.1 SES33807.1 SES34208.1 SES34208.1 SES34769.1 SES34769.1 SES34783.1 SES34783.1 SES35190.1 SES35190.1 pckG pckG SES35664.1 SES35664.1 SES35680.1 SES35680.1 SES35696.1 SES35696.1 SES35713.1 SES35713.1 SES35729.1 SES35729.1 SES35744.1 SES35744.1 SES36502.1 SES36502.1 SES38422.1 SES38422.1 SES38980.1 SES38980.1 SES38989.1 SES38989.1 SES40585.1 SES40585.1 SES40693.1 SES40693.1 SES42022.1 SES42022.1 SES42032.1 SES42032.1 SES42044.1 SES42044.1 SES42055.1 SES42055.1 SES42451.1 SES42451.1 SES42459.1 SES42459.1 SES42469.1 SES42469.1 SES42547.1 SES42547.1 SES42566.1 SES42566.1 SES42630.1 SES42630.1 SES42639.1 SES42639.1 SES42690.1 SES42690.1 SES42696.1 SES42696.1 SES42722.1 SES42722.1 SES42775.1 SES42775.1 SES42786.1 SES42786.1 SES43006.1 SES43006.1 SES43292.1 SES43292.1 SES43301.1 SES43301.1 SES44783.1 SES44783.1 SES45134.1 SES45134.1 SES45230.1 SES45230.1 SES46878.1 SES46878.1 mdh mdh SES46941.1 SES46941.1 SES46947.1 SES46947.1 SES47042.1 SES47042.1 sucD sucD sucC sucC SES47199.1 SES47199.1 SES47340.1 SES47340.1 acpS acpS fumC fumC SES47501.1 SES47501.1 SES47601.1 SES47601.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SES48502.13-hydroxybutyryl-CoA dehydrogenase. (396 aa)
SES48528.1Pyruvate dehydrogenase E1 component alpha subunit. (399 aa)
SES48532.1Pyruvate dehydrogenase E1 component beta subunit. (324 aa)
SES48536.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (530 aa)
SES49522.1Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. (597 aa)
SES49659.12-oxoglutarate ferredoxin oxidoreductase subunit beta. (365 aa)
SES49661.12-oxoglutarate ferredoxin oxidoreductase subunit alpha. (628 aa)
SES49710.1Acetyl/propionyl-CoA carboxylase, alpha subunit. (1840 aa)
SES49722.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
SES49743.1Purine catabolism regulatory protein. (511 aa)
SES49746.1Amino acid/polyamine/organocation transporter, APC superfamily. (494 aa)
SES49748.1Betaine-aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
SES49751.14-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (458 aa)
SES49755.1NADP-dependent aldehyde dehydrogenase. (528 aa)
SES49758.1formyl-CoA transferase; Belongs to the CoA-transferase III family. (405 aa)
SES49760.1glutaryl-CoA dehydrogenase. (400 aa)
SES49766.1Acyl dehydratase; Belongs to the UPF0336 family. (148 aa)
SES49768.1Acyl dehydratase. (140 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
SER64347.1Long-chain acyl-CoA synthetase. (620 aa)
SER64875.1Acyl-CoA reductase. (463 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
leuC3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (482 aa)
SER69252.12-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (527 aa)
SER69322.1Branched-chain amino acid aminotransferase. (372 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (355 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa)
SER69641.1Acetolactate synthase, small subunit. (170 aa)
SER69679.1Acetolactate synthase, large subunit. (626 aa)
ilvDDihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (573 aa)
SER70500.13-hydroxybutyryl-CoA dehydrogenase. (592 aa)
SER72451.12-oxoglutarate dehydrogenase E1 component. (1320 aa)
SER75054.1acetyl-CoA synthetase. (613 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (332 aa)
SER75115.1Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (358 aa)
SER75137.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (493 aa)
SER75786.1acyl-CoA dehydrogenase. (382 aa)
SER76205.1Enoyl-CoA hydratase/carnithine racemase. (278 aa)
SER77453.1(2S)-methylsuccinyl-CoA dehydrogenase. (400 aa)
SER77934.12-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase. (287 aa)
SER78250.1Citrate synthase; Belongs to the citrate synthase family. (431 aa)
SER80727.1Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (565 aa)
SER82136.1FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase. (430 aa)
SER82169.1succinyl-CoA:acetate CoA-transferase. (517 aa)
SER89901.12-oxoglutarate dehydrogenase E2 component. (631 aa)
SER89928.1Dihydrolipoamide dehydrogenase. (459 aa)
SER91487.1Long-chain acyl-CoA synthetase. (595 aa)
SER93631.1Aconitate hydratase. (934 aa)
SER94087.13-hydroxyacyl-CoA dehydrogenase. (722 aa)
SER94111.1acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (405 aa)
SER97589.1crotonobetaine/carnitine-CoA ligase. (516 aa)
SER97622.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
SES00163.1Acyl-coenzyme A oxidase. (645 aa)
SES00188.1Transcriptional regulator, TetR family. (245 aa)
SES00232.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (434 aa)
SES00256.13-oxoacyl-[acyl-carrier protein] reductase. (446 aa)
SES00286.1N-terminal half of MaoC dehydratase. (289 aa)
SES00315.1Uncharacterized membrane protein YgaE, UPF0421/DUF939 family. (419 aa)
SES07417.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
SES08032.1Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (262 aa)
SES08156.1Electron transfer flavoprotein beta subunit. (260 aa)
SES08184.1Electron transfer flavoprotein alpha subunit apoprotein. (319 aa)
SES08383.1Long-chain acyl-CoA synthetase. (511 aa)
SES08632.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1126 aa)
SES08998.1Malate dehydrogenase (oxaloacetate-decarboxylating). (472 aa)
SES10934.13-oxoacyl-[acyl-carrier protein] reductase. (251 aa)
SES11816.1Dihydrolipoamide dehydrogenase. (473 aa)
SES12400.1Glycolate oxidase. (452 aa)
SES12644.1NADP-dependent 3-hydroxy acid dehydrogenase YdfG. (253 aa)
SES12787.1Dihydrolipoamide dehydrogenase. (465 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (579 aa)
SES14898.1Protocatechuate 3,4-dioxygenase, beta subunit. (252 aa)
SES14914.1Protocatechuate 3,4-dioxygenase, alpha subunit. (196 aa)
SES14931.13-carboxy-cis,cis-muconate cycloisomerase. (471 aa)
SES14944.14-carboxymuconolactone decarboxylase. (134 aa)
SES14960.13-oxoadipate CoA-transferase alpha subunit. (230 aa)
SES14976.13-oxoadipate CoA-transferase, beta subunit. (226 aa)
SES14991.1Transcriptional regulator, IclR family. (265 aa)
SES15010.1Benzaldehyde dehydrogenase (NAD); Belongs to the aldehyde dehydrogenase family. (486 aa)
SES15028.1P-hydroxybenzoate 3-monooxygenase. (399 aa)
SES15730.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (786 aa)
SES16690.13-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (82 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase-3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (338 aa)
SES16759.1[acyl-carrier-protein] S-malonyltransferase. (320 aa)
SES16867.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (921 aa)
SES23693.1NADPH:quinone reductase. (307 aa)
SES23940.1Long-chain acyl-CoA synthetase. (566 aa)
SES23961.1Acyltransferase. (189 aa)
ppcPhosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (895 aa)
SES32042.1crotonobetainyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (275 aa)
SES32678.1fatty-acyl-CoA synthase. (504 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (663 aa)
SES33807.1acetyl-CoA synthetase. (566 aa)
SES34208.1propionyl-CoA synthetase. (639 aa)
SES34769.1Pyruvate dehydrogenase E1 component beta subunit. (343 aa)
SES34783.1Pyruvate dehydrogenase E1 component alpha subunit. (344 aa)
SES35190.1Alanine-synthesizing transaminase. (404 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (618 aa)
SES35664.1Acyl-CoA dehydrogenase. (401 aa)
SES35680.1Predicted kinase, aminoglycoside phosphotransferase (APT) family. (356 aa)
SES35696.1Glycine/D-amino acid oxidase. (482 aa)
SES35713.1Taurine---2-oxoglutarate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (456 aa)
SES35729.1Methylmalonate-semialdehyde dehydrogenase [acylating]. (499 aa)
SES35744.1DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain. (453 aa)
SES36502.1Hypothetical protein. (624 aa)
SES38422.1Ribose-phosphate pyrophosphokinase. (329 aa)
SES38980.1Enoyl-[acyl-carrier-protein] reductase [NADH]. (252 aa)
SES38989.13-oxoacyl-[acyl-carrier protein] reductase. (237 aa)
SES40585.13-hydroxyisobutyrate dehydrogenase. (294 aa)
SES40693.1Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (888 aa)
SES42022.1Succinate dehydrogenase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (252 aa)
SES42032.1Succinate dehydrogenase subunit A. (591 aa)
SES42044.1Succinate dehydrogenase subunit D. (150 aa)
SES42055.1Succinate dehydrogenase subunit C; Manually curated. (126 aa)
SES42451.1Aldehyde dehydrogenase family protein. (305 aa)
SES42459.1Aldehyde dehydrogenase (acceptor). (482 aa)
SES42469.1Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (339 aa)
SES42547.1Dihydrolipoamide dehydrogenase. (471 aa)
SES42566.1Biotin carboxyl carrier protein /biotin carboxylase. (590 aa)
SES42630.1butyryl-CoA dehydrogenase. (393 aa)
SES42639.1Acetyl-CoA carboxylase, carboxyltransferase component. (540 aa)
SES42690.1NADPH-dependent glutamate synthase beta chain. (568 aa)
SES42696.1Pyruvate-ferredoxin/flavodoxin oxidoreductase. (1191 aa)
SES42722.1Predicted hydrolase of the alpha/beta-hydrolase fold. (429 aa)
SES42775.1propionyl-CoA carboxylase carboxyltransferase subunit. (543 aa)
SES42786.1BirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase. (259 aa)
SES43006.1acyl-CoA dehydrogenase. (388 aa)
SES43292.13-oxoacid CoA-transferase subunit B. (212 aa)
SES43301.13-oxoacid CoA-transferase subunit A. (264 aa)
SES44783.14-aminobutyrate aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa)
SES45134.1hydroxymethylglutaryl-CoA lyase. (314 aa)
SES45230.1Citrate synthase; Belongs to the citrate synthase family. (365 aa)
SES46878.1Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (739 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (330 aa)
SES46941.1Protein of unknown function. (470 aa)
SES46947.1FdrA protein. (496 aa)
SES47042.1acetyl-CoA carboxylase carboxyl transferase subunit beta. (505 aa)
sucDsuccinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa)
sucCsuccinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (391 aa)
SES47199.1Putative serine esterase. (340 aa)
SES47340.1Succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase. (530 aa)
acpSHolo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (116 aa)
fumCFumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (477 aa)
SES47501.1L-threonine ammonia-lyase. (417 aa)
SES47601.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
Your Current Organism:
Phycicoccus cremeus
NCBI taxonomy Id: 587636
Other names: CGMCC 1.6963, JCM 17739, NBRC 104261, P. cremeus, Phycicoccus cremeus Zhang et al. 2011, Phycicoccus sp. V2M29, strain V2M29
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