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AKA21493.1 | Dihydroorotase; Pfam: Amidohydrolase. (445 aa) | ||||
purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa) | ||||
purK | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (360 aa) | ||||
spoT | Bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (701 aa) | ||||
gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa) | ||||
pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa) | ||||
dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa) | ||||
AKA21603.1 | Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (402 aa) | ||||
xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (189 aa) | ||||
coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) | ||||
AKA21821.1 | Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa) | ||||
AKA21832.1 | Dihydroorotase; Pfam: Amidohydrolase; TIGRFAM: pyrC_multi: dihydroorotase, multifunctional complex type. (423 aa) | ||||
pyrB | Pfam: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; TIGRFAM: asp_carb_tr: aspartate carbamoyltransferase; Pfam: Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; PRINTS: Aspartate/ornithine carbamoyltransferase superfamily signature; PRINTS: Aspartate carbamoyltransferase signature; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (334 aa) | ||||
pyrR | Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (168 aa) | ||||
amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (487 aa) | ||||
coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa) | ||||
AKA22586.1 | Hypoxanthine phosphoribosyltransferase; Pfam: Phosphoribosyl transferase domain. (185 aa) | ||||
ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) | ||||
guaB | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa) | ||||
guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (525 aa) | ||||
pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) | ||||
AKA23113.1 | Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (415 aa) | ||||
AKA23162.1 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (963 aa) | ||||
purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (220 aa) | ||||
purM | Phosphoribosylaminoimidazole synthetase; Pfam: AIR synthase related protein, C-terminal domain; Pfam: AIR synthase related protein, N-terminal domain; TIGRFAM: purM: phosphoribosylformylglycinamidine cyclo-ligase. (370 aa) | ||||
AKA23259.1 | Purine permease; TIGRFAM: ncs2: uracil-xanthine permease; Pfam: Permease family; TIGRFAM: pbuX: xanthine permease. (484 aa) | ||||
ppnP | Hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (94 aa) | ||||
purB | PRINTS: Fumarate lyase superfamily signature; TIGRFAM: purB: adenylosuccinate lyase; Pfam: Lyase; Pfam: Adenylosuccinate lyase C-terminal; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) | ||||
AKA23984.1 | Pfam: Lyase; SMART: Adenylosuccinate lyase C-terminus; PRINTS: Fumarate lyase superfamily signature; Pfam: Adenylosuccinate lyase C-terminus; PRINTS: Argininosuccinate lyase family signature; TIGRFAM: purB: adenylosuccinate lyase. (477 aa) | ||||
AKA23985.1 | SMART: Adenylosuccinate lyase C-terminus; Pfam: Lyase; PRINTS: Fumarate lyase superfamily signature; PRINTS: Argininosuccinate lyase family signature; Pfam: Adenylosuccinate lyase C-terminus. (482 aa) | ||||
AKA24474.1 | Pfam: Survival protein SurE. (313 aa) | ||||
AKA25201.1 | LOG family protein; Pfam: Domain of unknown function (DUF3412); Pfam: Possible lysine decarboxylase; Pfam: Domain of unknown function (DUF4478). (457 aa) | ||||
AKA25401.1 | Hypothetical protein; Pfam: Inosine-uridine preferring nucleoside hydrolase; Belongs to the IUNH family. (342 aa) | ||||
purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa) | ||||
AKA25426.1 | Pfam: Colicin V production protein. (141 aa) | ||||
apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa) | ||||
pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (342 aa) | ||||
tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) | ||||
pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (232 aa) | ||||
purC | Pfam: SAICAR synthetase; TIGRFAM: purC: phosphoribosylaminoimidazolesuccinocarboxamide synthase. (236 aa) | ||||
dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa) | ||||
pcm | protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (225 aa) | ||||
surE | Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (249 aa) | ||||
truD | tRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (352 aa) | ||||
pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa) | ||||
adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa) | ||||
purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1299 aa) | ||||
carB | Pfam: Carbamoyl-phosphate synthase L chain, N-terminal domain; Pfam: Carbamoyl-phosphate synthase L chain, ATP binding domain; SMART: MGS-like domain; TIGRFAM: CPSaseII_lrg: carbamoyl-phosphate synthase, large subunit; SMART: Carbamoyl-phosphate synthetase large chain, oligomerisation domain; PRINTS: Carbamoyl-phosphate synthase protein CPSase domain signature; Pfam: Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Pfam: MGS-like domain; Belongs to the CarB family. (1073 aa) | ||||
carA | Carbamoyl phosphate synthase small subunit; PRINTS: Anthranilate synthase component II signature; Pfam: Glutamine amidotransferase class-I; TIGRFAM: CPSaseIIsmall: carbamoyl-phosphate synthase, small subunit; Pfam: Carbamoyl-phosphate synthase small chain, CPSase domain; PRINTS: Glutamine amidotransferase superfamily signature; SMART: Carbamoyl-phosphate synthase small chain, CPSase domain; PRINTS: Carbamoyl-phosphate synthase protein GATase domain signature; Belongs to the CarA family. (343 aa) | ||||
AKA26817.1 | Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (317 aa) | ||||
purH | Purine biosynthesis protein purH; Pfam: AICARFT/IMPCHase bienzyme; SMART: MGS-like domain; Pfam: MGS-like domain; SMART: AICARFT/IMPCHase bienzyme; TIGRFAM: purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (535 aa) | ||||
purD | Phosphoribosylamine--glycine ligase; Pfam: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; TIGRFAM: purD: phosphoribosylamine--glycine ligase; Pfam: Phosphoribosylglycinamide synthetase, N domain; Pfam: Phosphoribosylglycinamide synthetase, C domain; Belongs to the GARS family. (431 aa) | ||||
purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) | ||||
AKA27222.1 | Pfam: Haloacid dehalogenase-like hydrolase; TIGRFAM: HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3. (220 aa) |