STRINGSTRING
AKA21493.1 AKA21493.1 purE purE purK purK spoT spoT gmk gmk pyrE pyrE dut dut AKA21603.1 AKA21603.1 xpt xpt coaD coaD AKA21821.1 AKA21821.1 AKA21832.1 AKA21832.1 pyrB pyrB pyrR pyrR amn amn coaE coaE AKA22586.1 AKA22586.1 ndk ndk guaB guaB guaA guaA pyrC pyrC AKA23113.1 AKA23113.1 AKA23162.1 AKA23162.1 purN purN purM purM AKA23259.1 AKA23259.1 ppnP ppnP purB purB AKA23984.1 AKA23984.1 AKA23985.1 AKA23985.1 AKA24474.1 AKA24474.1 AKA25201.1 AKA25201.1 AKA25401.1 AKA25401.1 purF purF AKA25426.1 AKA25426.1 apt apt pyrD pyrD tmk tmk pyrF pyrF purC purC dcd dcd pcm pcm surE surE truD truD pyrG pyrG adk adk purL purL carB carB carA carA AKA26817.1 AKA26817.1 purH purH purD purD purA purA AKA27222.1 AKA27222.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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AKA21493.1Dihydroorotase; Pfam: Amidohydrolase. (445 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (360 aa)
spoTBifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (701 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa)
AKA21603.1Phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (402 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (189 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
AKA21821.1Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa)
AKA21832.1Dihydroorotase; Pfam: Amidohydrolase; TIGRFAM: pyrC_multi: dihydroorotase, multifunctional complex type. (423 aa)
pyrBPfam: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; TIGRFAM: asp_carb_tr: aspartate carbamoyltransferase; Pfam: Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; PRINTS: Aspartate/ornithine carbamoyltransferase superfamily signature; PRINTS: Aspartate carbamoyltransferase signature; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (334 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (168 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (487 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa)
AKA22586.1Hypoxanthine phosphoribosyltransferase; Pfam: Phosphoribosyl transferase domain. (185 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
guaBInosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (525 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa)
AKA23113.1Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (415 aa)
AKA23162.1Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (963 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (220 aa)
purMPhosphoribosylaminoimidazole synthetase; Pfam: AIR synthase related protein, C-terminal domain; Pfam: AIR synthase related protein, N-terminal domain; TIGRFAM: purM: phosphoribosylformylglycinamidine cyclo-ligase. (370 aa)
AKA23259.1Purine permease; TIGRFAM: ncs2: uracil-xanthine permease; Pfam: Permease family; TIGRFAM: pbuX: xanthine permease. (484 aa)
ppnPHypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (94 aa)
purBPRINTS: Fumarate lyase superfamily signature; TIGRFAM: purB: adenylosuccinate lyase; Pfam: Lyase; Pfam: Adenylosuccinate lyase C-terminal; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
AKA23984.1Pfam: Lyase; SMART: Adenylosuccinate lyase C-terminus; PRINTS: Fumarate lyase superfamily signature; Pfam: Adenylosuccinate lyase C-terminus; PRINTS: Argininosuccinate lyase family signature; TIGRFAM: purB: adenylosuccinate lyase. (477 aa)
AKA23985.1SMART: Adenylosuccinate lyase C-terminus; Pfam: Lyase; PRINTS: Fumarate lyase superfamily signature; PRINTS: Argininosuccinate lyase family signature; Pfam: Adenylosuccinate lyase C-terminus. (482 aa)
AKA24474.1Pfam: Survival protein SurE. (313 aa)
AKA25201.1LOG family protein; Pfam: Domain of unknown function (DUF3412); Pfam: Possible lysine decarboxylase; Pfam: Domain of unknown function (DUF4478). (457 aa)
AKA25401.1Hypothetical protein; Pfam: Inosine-uridine preferring nucleoside hydrolase; Belongs to the IUNH family. (342 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa)
AKA25426.1Pfam: Colicin V production protein. (141 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (342 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (232 aa)
purCPfam: SAICAR synthetase; TIGRFAM: purC: phosphoribosylaminoimidazolesuccinocarboxamide synthase. (236 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa)
pcmprotein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (225 aa)
surEStationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (249 aa)
truDtRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (352 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1299 aa)
carBPfam: Carbamoyl-phosphate synthase L chain, N-terminal domain; Pfam: Carbamoyl-phosphate synthase L chain, ATP binding domain; SMART: MGS-like domain; TIGRFAM: CPSaseII_lrg: carbamoyl-phosphate synthase, large subunit; SMART: Carbamoyl-phosphate synthetase large chain, oligomerisation domain; PRINTS: Carbamoyl-phosphate synthase protein CPSase domain signature; Pfam: Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Pfam: MGS-like domain; Belongs to the CarB family. (1073 aa)
carACarbamoyl phosphate synthase small subunit; PRINTS: Anthranilate synthase component II signature; Pfam: Glutamine amidotransferase class-I; TIGRFAM: CPSaseIIsmall: carbamoyl-phosphate synthase, small subunit; Pfam: Carbamoyl-phosphate synthase small chain, CPSase domain; PRINTS: Glutamine amidotransferase superfamily signature; SMART: Carbamoyl-phosphate synthase small chain, CPSase domain; PRINTS: Carbamoyl-phosphate synthase protein GATase domain signature; Belongs to the CarA family. (343 aa)
AKA26817.1Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (317 aa)
purHPurine biosynthesis protein purH; Pfam: AICARFT/IMPCHase bienzyme; SMART: MGS-like domain; Pfam: MGS-like domain; SMART: AICARFT/IMPCHase bienzyme; TIGRFAM: purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (535 aa)
purDPhosphoribosylamine--glycine ligase; Pfam: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; TIGRFAM: purD: phosphoribosylamine--glycine ligase; Pfam: Phosphoribosylglycinamide synthetase, N domain; Pfam: Phosphoribosylglycinamide synthetase, C domain; Belongs to the GARS family. (431 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
AKA27222.1Pfam: Haloacid dehalogenase-like hydrolase; TIGRFAM: HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3. (220 aa)
Your Current Organism:
Pseudomonas chlororaphis
NCBI taxonomy Id: 587753
Other names: ATCC 9446, Bacillus chlororaphis, CCUG 552 B, CFBP 2132, CIP 63.22, DSM 50083, HAMBI 2011, IFO 3904, JCM 2778, LMG 5004, LMG:5004, NBRC 3904, NCCB 76041, NCIB 9392, NCIMB 9392, NCTC 13002, P. chlororaphis, Pseudomonas sp. UFB2
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