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miaB miaB lipA lipA gltD gltD APG52402.1 APG52402.1 ilvD_2 ilvD_2 thiC thiC thiH thiH hemN_2 hemN_2 nfuA nfuA APG51916.1 APG51916.1 APG51917.1 APG51917.1 fdoH_2 fdoH_2 queG queG APG52217.1 APG52217.1 yhbU_2 yhbU_2 APG52223.1 APG52223.1 dmsB_3 dmsB_3 fumB fumB kamA kamA frdB frdB dmsA_2 dmsA_2 fdhF fdhF sufB sufB ttcA ttcA APG49799.1 APG49799.1 fnr fnr moaA-2 moaA-2 rnfB rnfB rnfC rnfC nth nth acnA acnA sdaA sdaA APG50332.1 APG50332.1 dmsB_1 dmsB_1 nuoI nuoI nuoG nuoG nuoF nuoF nuoB nuoB ispG ispG rlmN rlmN acnB acnB leuC leuC yccM yccM napA napA napF napF rumA rumA rimO rimO cysI cysI queE queE hemN_3 hemN_3 mutY mutY ispH ispH narG narG fdnH fdnH APG53072.1 APG53072.1 APG53071.1 APG53071.1 pflA pflA rumB rumB sdaB sdaB dmsB_2 dmsB_2 moaA moaA bioB bioB nadA nadA sdhB_3 sdhB_3
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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gene fusions
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miaBtRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (476 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)
gltDGlutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
APG52402.1Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (560 aa)
ilvD_2Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (616 aa)
thiCPhosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (649 aa)
thiHThiamine biosynthesis protein ThiH; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
hemN_2Oxygen-independent coproporphyrinogen III oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa)
nfuAFe-S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (192 aa)
APG51916.1Sulfate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
APG51917.1Formate dehydrogenase-N subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (803 aa)
fdoH_2Formate dehydrogenase subunit beta; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (314 aa)
queGtRNA epoxyqueuosine(34) reductase QueG; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (385 aa)
APG52217.1U32 family peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
yhbU_2Protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
APG52223.1Anaerobic ribonucleotide reductase-activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa)
dmsB_3Dimethylsulfoxide reductase, chain B; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
fumBFumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa)
kamAEF-P beta-lysylation protein EpmB; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
frdBPart of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
dmsA_2Tetrathionate reductase subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1028 aa)
fdhFCbbBc protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (762 aa)
sufBFe-S cluster assembly protein SufB; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
ttcAtRNA 2-thiocytidine(32) synthetase TtcA; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (304 aa)
APG49799.1TIGR01212 family radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
fnrTranscriptional regulator; Global transcription factor that controls the expression of over 100 target genes in response to anoxia; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
moaA-2His-Xaa-Ser system radical SAM maturase HxsC; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
rnfBElectron transport complex subunit RsxB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (208 aa)
rnfCElectron transport complex subunit RsxC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (895 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (890 aa)
sdaAL-serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
APG50332.1AmmeMemoRadiSam system radical SAM enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
dmsB_1Dimethyl sulfoxide reductase subunit A; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
nuoINADH-quinone oxidoreductase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (180 aa)
nuoGNADH-quinone oxidoreductase subunit G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (910 aa)
nuoFNADH-quinone oxidoreductase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (452 aa)
nuoBNADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (224 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity). Involved in density-dependent regulation of 2'-N- acetyltransferase. (373 aa)
rlmNDual-specificity RNA methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (393 aa)
acnBBifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (865 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
yccMQuinol dehydrogenase ferredoxin subunit NapH; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
napANitrate reductase catalytic subunit; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa)
napFFerredoxin-type protein NapF; Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm; Belongs to the NapF family. (163 aa)
rumA23S rRNA (uracil(1939)-C(5))-methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (443 aa)
rimORibosomal protein S12 methylthiotransferase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (444 aa)
cysISulfite reductase subunit beta; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (576 aa)
queE7-carboxy-7-deazaguanine synthase QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa)
hemN_3YggW family oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (379 aa)
mutYA/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (354 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (317 aa)
narGNitrate reductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1253 aa)
fdnHFormate dehydrogenase subunit beta; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (293 aa)
APG53072.1Formate dehydrogenase-N subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (803 aa)
APG53071.1Sulfate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
pflAPyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (264 aa)
rumB23S rRNA (uracil(747)-C(5))-methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily. (375 aa)
sdaBHypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa)
dmsB_2Dimethylsulfoxide reductase, chain B; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
moaACyclic pyranopterin phosphate synthase; Together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (345 aa)
nadAQuinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (346 aa)
sdhB_3Succinate dehydrogenase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
Your Current Organism:
Providencia stuartii
NCBI taxonomy Id: 588
Other names: ATCC 29914, CCUG 14805, CDC 2896-68, CIP 104687, DSM 4539, LMG 3260, LMG:3260, NCTC 11800, P. stuartii, Proteus stuartii
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