STRINGSTRING
APG50364.1 APG50364.1 ndh ndh lolC lolC lolD_2 lolD_2 lolE lolE APG50282.1 APG50282.1 APG50267.1 APG50267.1 acrA_2 acrA_2 ecfA1_1 ecfA1_1 ecfA1_2 ecfA1_2 emrE_2 emrE_2 potA_1 potA_1 potH potH znuC znuC znuB znuB btuD btuD btuC btuC APG49656.1 APG49656.1 mntB_2-2 mntB_2-2 mntB_2 mntB_2 APG51878.1 APG51878.1 APG51925.1 APG51925.1 APG51943.1 APG51943.1 APG51979.1 APG51979.1 argH argH btuB btuB mdtE mdtE lptF lptF lptG lptG APG52274.1 APG52274.1 potA_2 potA_2 potB potB frdD frdD frdC frdC frdB frdB lptB_1-2 lptB_1-2 APG52529.1 APG52529.1 tolC_1 tolC_1 BGK56_17190 BGK56_17190 metQ metQ metN_2-2 metN_2-2 proX_2 proX_2 ndhC ndhC nuoC nuoC nuoE nuoE efeO efeO APG50951.1 APG50951.1 cyoC cyoC cyoD cyoD exbD exbD tatC tatC tatB tatB tatA tatA bepF bepF APG51503.1 APG51503.1 cysW_1-2 cysW_1-2 potA_3 potA_3 kefB kefB ywrO ywrO tolC_2 tolC_2 proW proW proV proV kdpC kdpC kdpB kdpB kdpA kdpA sdhC sdhC sdhA_2 sdhA_2 sdhB_3 sdhB_3 APG52842.1 APG52842.1 APG52845.1 APG52845.1 macA_2 macA_2 macB macB APG52964.1 APG52964.1 aarD aarD ompC ompC ompA ompA efeU efeU atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB atpI atpI yqjC yqjC metN_2 metN_2 metI_1 metI_1 cysA_1 cysA_1 cysW_2 cysW_2 yfhL yfhL ompD ompD clcA clcA APG50799.1 APG50799.1 acrA_1 acrA_1 folK folK tpd tpd nuoF nuoF nuoG nuoG nuoJ nuoJ nuoL nuoL nuoM nuoM emrE_1 emrE_1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APG50364.1Iron ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
ndhNADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
lolCOuter membrane-specific lipoprotein transporter subunit LolC; Part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
lolD_2Lipoprotein releasing system, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. (233 aa)
lolELipoprotein transporter subunit LolE; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
APG50282.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (116 aa)
APG50267.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
acrA_2Multidrug transporter subunit MdtA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (409 aa)
ecfA1_1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
ecfA1_2Cobalt ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
emrE_2Multidrug DMT transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
potA_1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (360 aa)
potHSpermidine/putrescine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
znuCZinc ABC transporter ATP-binding protein ZnuC; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (255 aa)
znuBZinc ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
btuDCobalamin ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
btuCVitamin B12 ABC transporter permease BtuC; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane. (333 aa)
APG49656.1Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
mntB_2-2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
mntB_2Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
APG51878.1ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
APG51925.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
APG51943.1ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
APG51979.1Polysaccharide export protein Wza; Required for the translocation of capsular polysaccharide through the outer membrane; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
argHArgininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
btuBTonB-dependent vitamin B12 receptor; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily. (628 aa)
mdtEMultidrug efflux RND transporter permease subunit; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (406 aa)
lptFLipopolysaccharide ABC transporter permease LptF; With LptBGC is involved in lipopolysaccharide export; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
lptGLipopolysaccharide ABC transporter permease LptG; With LptABCF is involved in the transport of lipopolysaccharides; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
APG52274.1Restriction endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
potA_2Putrescine/spermidine ABC transporter ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (369 aa)
potBSpermidine/putrescine ABC transporter permease PotB; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
frdDFumarate reductase; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (117 aa)
frdCFumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa)
frdBPart of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
lptB_1-2LPS export ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
APG52529.1Siderophore ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
tolC_1Outer membrane channel protein TolC; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
BGK56_17190Type IV secretion protein Rhs; Frameshifted; incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
metQDL-methionine transporter substrate-binding subunit; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
metN_2-2D-methionine ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
proX_2Glycine betaine ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
ndhCNADH-quinone oxidoreductase subunit A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (147 aa)
nuoCNADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. (598 aa)
nuoENADH-quinone oxidoreductase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
efeOHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
APG50951.16-phosphogluconolactonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
cyoCCytochrome o ubiquinol oxidase subunit III; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
cyoDCytochrome o ubiquinol oxidase subunit IV; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
exbDTonB system transport protein ExbD; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
tatCTwin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (257 aa)
tatBTwin arginine-targeting protein translocase TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (182 aa)
tatAPreprotein translocase subunit TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. Belongs to the TatA/E family. (97 aa)
bepFEfflux transporter periplasmic adaptor subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (369 aa)
APG51503.1ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
cysW_1-2ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
potA_3ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (338 aa)
kefBGlutathione-regulated potassium-efflux system protein KefB; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (601 aa)
ywrOGlutathione-regulated potassium-efflux system ancillary protein KefG; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB. (184 aa)
tolC_2Outer membrane channel protein TolC; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
proWProline/betaine ABC transporter permease ProW; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
proVGlycine betaine/L-proline ABC transporter ATP-binding protein; With ProWX is involved in the high-affinity uptake of glycine betaine; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
kdpCPotassium-transporting ATPase subunit C; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (197 aa)
kdpBPotassium-transporting ATPase subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (687 aa)
kdpAPotassium-transporting ATPase subunit KdpA; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (567 aa)
sdhCSuccinate dehydrogenase cytochrome b556 large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
sdhA_2Succinate dehydrogenase flavoprotein subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
sdhB_3Succinate dehydrogenase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
APG52842.1Porin; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
APG52845.1Molybdate ABC transporter ATP-binding protein ModF; Derived by automated computational analysis using gene prediction method: Protein Homology. (494 aa)
macA_2Macrolide transporter subunit MacA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (367 aa)
macBMacrolide ABC transporter permease/ATP-binding protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (647 aa)
APG52964.1In Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; Derived by automated computational analysis using gene prediction method: Protein Homology. (580 aa)
aarDCysteine/glutathione ABC transporter permease/ATP-binding protein CydD; Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity); Belongs to the ABC transporter superfamily. (588 aa)
ompCPorin; Allows for ions and hydrophilic solutes to cross the outer membrane; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Gram-negative porin family. (376 aa)
ompAPorin OmpA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (357 aa)
efeUHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
atpCF0F1 ATP synthase subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (141 aa)
atpDF0F1 ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (460 aa)
atpGF0F1 ATP synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa)
atpAF0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa)
atpHF0F1 ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (177 aa)
atpFF0F1 ATP synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa)
atpEATP F0F1 synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (77 aa)
atpBF0F1 ATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (272 aa)
atpIF0F1 ATP synthase subunit I; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
yqjCHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
metN_2Methionine ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (337 aa)
metI_1Methionine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
cysA_1Sulfate/thiosulfate transporter subunit; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (362 aa)
cysW_2Sulfate ABC transporter permease subunit CysW; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
yfhLFerredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa)
ompDPorin; Allows for ions and hydrophilic solutes to cross the outer membrane; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
clcAChloride channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
APG50799.1Ferredoxin-type protein NapG; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
acrA_1Efflux transporter periplasmic adaptor subunit; With AcrD and TolC forms a transport system involved in resistance to a number of compounds including lipophilic antibiotics; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (395 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
tpdHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
nuoFNADH-quinone oxidoreductase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (452 aa)
nuoGNADH-quinone oxidoreductase subunit G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (910 aa)
nuoJNADH:ubiquinone oxidoreductase subunit J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (181 aa)
nuoLNADH-quinone oxidoreductase subunit L; Derived by automated computational analysis using gene prediction method: Protein Homology. (618 aa)
nuoMNADH-quinone oxidoreductase subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (506 aa)
emrE_1Multidrug DMT transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (111 aa)
Your Current Organism:
Providencia stuartii
NCBI taxonomy Id: 588
Other names: ATCC 29914, CCUG 14805, CDC 2896-68, CIP 104687, DSM 4539, LMG 3260, LMG:3260, NCTC 11800, P. stuartii, Proteus stuartii
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