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| | fadR | Fatty acid metabolism regulator; Multifunctional regulator of fatty acid metabolism. (238 aa) |
| | topB_1 | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (643 aa) |
| | abgR_1 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (291 aa) |
| | hns | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the histone-like protein H-NS family. (136 aa) |
| | topA_1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (864 aa) |
| | cysB | Transcriptional regulator CysB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (324 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa) |
| | benM_1 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (300 aa) |
| | nemR | Transcriptional repressor NemR; Represses nemA which is involved in degradation of N-ethylmaleimide; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa) |
| | marR | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa) |
| | APG49954.1 | TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa) |
| | yjiR | GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa) |
| | crp_1 | Cyclic AMP receptor protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa) |
| | ada | 6-O-methylguanine DNA methyltransferase; Regulates genes involved in the repair of alkylated DNA; repairs DNA containing 6-O-methylguanine; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa) |
| | dmlR_2-2 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | APG49937.1 | AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa) |
| | gcvA_1 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (294 aa) |
| | rhaR | AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa) |
| | dmlR_2 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (300 aa) |
| | gabR | GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (493 aa) |
| | fnr | Transcriptional regulator; Global transcription factor that controls the expression of over 100 target genes in response to anoxia; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa) |
| | allS_2 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (287 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (205 aa) |
| | yebC | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa) |
| | soxS_2 | AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa) |
| | gltC_2 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (295 aa) |
| | ydcR | GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa) |
| | rutR | TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa) |
| | tyrR | DNA-binding transcriptional regulator TyrR; Derived by automated computational analysis using gene prediction method: Protein Homology. (519 aa) |
| | pspF | Phage shock protein operon transcriptional activator; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa) |
| | purR_1 | Transcriptional repressor PurR; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. (341 aa) |
| | allS_3 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (301 aa) |
| | APG49711.1 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa) |
| | soxS_3 | AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (123 aa) |
| | ihfA | Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (98 aa) |
| | gntR_1 | LacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa) |
| | kstR2_2 | TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa) |
| | uvrY | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa) |
| | dpiA | Two-component response regulator DpiA; Regulates the expression of citrate fermentation genes; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa) |
| | yvdT | Transcriptional regulator BetI; Repressor involved in choline regulation of the bet genes. (198 aa) |
| | cas1 | Subtype I-F CRISPR-associated endonuclease Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (325 aa) |
| | flhC_1 | Transcriptional regulator FlhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (195 aa) |
| | flhD | Flagellar transcriptional activator FlhD; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (115 aa) |
| | glcR_1 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa) |
| | putA | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1327 aa) |
| | rcsA | LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa) |
| | lexA | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (207 aa) |
| | zur | Transcriptional repressor; Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Fur family. (171 aa) |
| | APG51509.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa) |
| | gntR_2 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa) |
| | adiY | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa) |
| | nifA | Transcriptional regulator; Sigma 54-dependent; regulates genes involved in forming a 2',3'-cyclic phosphodiester on RNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa) |
| | deoR | DeoR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa) |
| | dnaB | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (469 aa) |
| | uvrA | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (944 aa) |
| | hcaR_1 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (311 aa) |
| | ssb_2 | Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (171 aa) |
| | aarP | Transcriptional regulator; Transcriptional activator of 2'-N-acetyltransferase. (135 aa) |
| | cynR_2 | Homocysteine-binding; positive regulator of metA, metE and metH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (318 aa) |
| | rfaH | Transcriptional activator RfaH; Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains. (163 aa) |
| | narL_2 | Two-component system response regulator NarL; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa) |
| | nreC | Helix-turn-helix transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa) |
| | csgD | Helix-turn-helix transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa) |
| | dmlR_6 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (307 aa) |
| | fecI_2 | RNA polymerase subunit sigma; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (178 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (462 aa) |
| | trpR | Trp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. (106 aa) |
| | rob_2 | Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa) |
| | arcA | Two-component system response regulator ArcA; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa) |
| | nhaR | Transcriptional activator NhaR; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (307 aa) |
| | phoB | Phosphate regulon transcriptional regulatory protein PhoB; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa) |
| | nrdR | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (149 aa) |
| | hupB_1 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (91 aa) |
| | gltR_1 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (283 aa) |
| | BGK56_09595 | Amino acid ABC transporter substrate-binding protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa) |
| | oxyR_2-2 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (227 aa) |
| | feaR | 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa) |
| | mgrA | Homoprotocatechuate degradation operon regulator, HpaR; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa) |
| | dmlR_1 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (306 aa) |
| | rep | ATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (673 aa) |
| | hcaR_2 | Transcriptional regulator IlvY; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (298 aa) |
| | cynR_2-2 | Transposase; Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon. (281 aa) |
| | birA | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (325 aa) |
| | fabR | DNA-binding transcriptional regulator FabR; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. (218 aa) |
| | oxyR_3 | DNA-binding transcriptional regulator OxyR; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (302 aa) |
| | metJ | Transcriptional repressor protein MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa) |
| | catM | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (301 aa) |
| | ascG | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa) |
| | cytR_2 | LacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa) |
| | helD | DNA helicase IV; Catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; Derived by automated computational analysis using gene prediction method: Protein Homology. (684 aa) |
| | matP | Ter macrodomain-binding protein MatP; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. (154 aa) |
| | mukB | Cell division protein MukB; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division; Belongs to the SMC family. MukB subfamily. (1481 aa) |
| | ihfB | Integration host factor subunit beta; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (95 aa) |
| | seqA | Replication initiation regulator SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. (182 aa) |
| | fur | Ferric iron uptake transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Fur family. (149 aa) |
| | ftsK | Cell division protein FtsK; Derived by automated computational analysis using gene prediction method: Protein Homology. (1193 aa) |
| | ripA_2 | AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa) |
| | APG52897.1 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa) |
| | dps | DNA starvation/stationary phase protection protein Dps; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction; Belongs to the Dps family. (167 aa) |
| | dinG | ATP-dependent DNA helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase. (702 aa) |
| | acnR | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa) |
| | ripA_3-2 | AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa) |
| | kdpE | Two-component system response regulator KdpE; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa) |
| | APG52737.1 | DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa) |
| | chbR | Transcriptional regulator ChbR; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa) |
| | ssb_1 | Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa) |
| | APG52620.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 'phage' integrase family. (354 aa) |
| | ygdG | Flap endonuclease Xni; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. (252 aa) |
| | gcvA_2 | Transcriptional regulator GcvA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (313 aa) |
| | recD | Exodeoxyribonuclease V subunit alpha; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (619 aa) |
| | recB | Exodeoxyribonuclease V subunit beta; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and rep [...] (1205 aa) |
| | recC | Exodeoxyribonuclease V subunit gamma; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (1124 aa) |
| | polB | Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; Derived by automated computational analysis using gene prediction method: Protein Homology. (783 aa) |
| | rapA_2 | RNA polymerase-binding ATPase; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. (968 aa) |
| | parC | DNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (752 aa) |
| | parE | DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (631 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (581 aa) |
| | rpoD | RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (617 aa) |
| | dmlR_4 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (297 aa) |
| | allS_4 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (298 aa) |
| | APG52436.1 | RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (481 aa) |
| | fis | Fis family transcriptional regulator; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. (98 aa) |
| | yvoA_3 | Histidine utilization repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa) |
| | rpoH | RNA polymerase factor sigma-32; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (292 aa) |
| | mcbR | GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa) |
| | soxS_4 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa) |
| | benM_2 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (301 aa) |
| | lutR_1 | GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa) |
| | tetD_2 | Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa) |
| | purR_2 | LacI family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa) |
| | yehT | Two-component system response regulator YehT; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa) |
| | greA | Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (158 aa) |
| | APG52189.1 | DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa) |
| | APG52188.1 | DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa) |
| | APG52187.1 | DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (156 aa) |
| | mprA | Response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa) |
| | priB | Primosomal replication protein N; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (55 aa) |
| | nsrR | Transcriptional repressor NsrR; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. (140 aa) |
| | uvrD | DNA helicase II; Derived by automated computational analysis using gene prediction method: Protein Homology. (720 aa) |
| | xerC_2 | Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges t [...] (309 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (732 aa) |
| | cytR_3 | DNA-binding transcriptional regulator CytR; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa) |
| | yycF | Response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa) |
| | mutM | Lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (269 aa) |
| | slmA | Nucleoid occlusion factor SlmA; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. (199 aa) |
| | yegW | GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa) |
| | dnaA | Chromosomal replication initiation protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (463 aa) |
| | dnaN | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa) |
| | recF | DNA replication/repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (364 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (804 aa) |
| | APG51886.1 | TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa) |
| | rbsR | Transcriptional regulator RbsR; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa) |
| | pdhR_2 | GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa) |
| | dmlR_5 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (303 aa) |
| | hslR | Heat-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HSP15 family. (135 aa) |
| | APG51798.1 | Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa) |
| | tetR_2 | TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa) |
| | invF | AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa) |
| | lutR_2 | GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa) |
| | allS_1-2 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (310 aa) |
| | glpR_2-2 | Transcriptional regulator; Represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa) |
| | feoC | Ferrous iron transporter C; May function as a transcriptional regulator that controls feoABC expression. (83 aa) |
| | greB | Transcription elongation factor GreB; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. (161 aa) |
| | ompR | Two-component system response regulator OmpR; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa) |
| | ampR | LysR family transcriptional regulator; This protein is a positive regulator of gene expression of beta-lactamase (AmpC); Belongs to the LysR transcriptional regulatory family. (292 aa) |
| | glnG | Nitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (481 aa) |
| | abgR_2 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (306 aa) |
| | gltR | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (283 aa) |
| | polA_2 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (930 aa) |
| | glpR_2 | DeoR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa) |
| | crp_1-2 | Transcriptional regulator Crp; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa) |
| | hupA | DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa) |
| | fecI_1 | RNA polymerase subunit sigma-24; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (176 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (351 aa) |
| | recA | Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (355 aa) |
| | treR | Trehalose operon repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa) |
| | rpoS | RNA polymerase sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (328 aa) |
| | mutS | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (854 aa) |
| | cynR_1 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (301 aa) |
| | tetR_1 | TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa) |
| | tetC_2 | Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa) |
| | tetD_1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa) |
| | oxyR_2 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (304 aa) |
| | APG50932.1 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa) |
| | fixJ_2-2 | Helix-turn-helix transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa) |
| | cytR_1 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa) |
| | APG50914.1 | TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa) |
| | ybaB | Nucleoid-associated protein, YbaB/EbfC family; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (109 aa) |
| | rbsK_1 | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (406 aa) |
| | rob_1 | Right origin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa) |
| | allS_1 | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (304 aa) |
| | leuO | Transcriptional regulator LeuO; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | fruR | DNA-binding transcriptional regulator FruR; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa) |
| | mraZ | Cell division/cell wall cluster transcriptional repressor MraZ; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster. (152 aa) |
| | pdhR_1 | Transcriptional regulator PdhR; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa) |
| | iciA | Transcriptional regulator ArgP; Controls the transcription of genes involved in arginine and lysine metabolism; Belongs to the LysR transcriptional regulatory family. (300 aa) |
| | xerD_1 | Site-specific tyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerD specifical [...] (307 aa) |
| | rhaS | AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa) |
| | galR | DNA-binding transcriptional regulator GalS; Controls transcription of galETKM; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa) |
| | prpR | Propionate catabolism operon regulatory protein PrpR; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa) |
| | intA_1 | Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 'phage' integrase family. (413 aa) |
| | rpoE | RNA polymerase sigma factor RpoE; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa) |
| | qseF | Two-component system response regulator GlrR; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa) |
| | iscR | Fe-S cluster assembly transcriptional regulator IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. (165 aa) |
| | rodZ | Hypothetical protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. Belongs to the RodZ family. (314 aa) |
| | intS_2 | Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 'phage' integrase family. (393 aa) |
| | yvoA_1 | Histidine utilization repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa) |
| | basR | DNA-binding response regulator; Transcriptional activator of tricarboxylate transport system genes; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa) |
| | ripA_3 | AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa) |
| | gltC_2-2 | Transcriptional regulator LrhA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (309 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (867 aa) |
| | rcsB | DNA-binding response regulator; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. (216 aa) |
| | ydfH | GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa) |
| | rssB | DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa) |
| | cysL | LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (287 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1148 aa) |
| | phoP_1 | Response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa) |
| | soxS_1 | AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (127 aa) |
| | baeR | Two-component system response regulator BaeR; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa) |
| | APG50169.1 | DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa) |
| | narL_1 | Nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa) |
| | yvoA_2 | HipA protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa) |
| | kstR2_1 | TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa) |
