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| | sigA | RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (359 aa) |
| | Cpap_0058 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (795 aa) |
| | Cpap_0067 | KEGG: bbe:BBR47_29580 hypothetical protein. (520 aa) |
| | Cpap_0100 | TIGRFAM: phosphate acetyltransferase; KEGG: cce:Ccel_2137 phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase. (331 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa) |
| | Cpap_0127 | RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: clj:CLJU_c16190 putative RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. ECF subfamily. (179 aa) |
| | Cpap_0128 | KEGG: bcl:ABC4052 hypothetical protein. (323 aa) |
| | Cpap_0161 | KEGG: hmo:HM1_0600 hypothetical protein. (77 aa) |
| | Cpap_0175 | KEGG: cce:Ccel_2740 hypothetical protein. (310 aa) |
| | Cpap_0179 | KEGG: hmo:HM1_0136 hypothetical protein. (138 aa) |
| | Cpap_0220 | PFAM: Fumble domain protein; KEGG: cce:Ccel_0705 pantothenate kinase. (281 aa) |
| | Cpap_0230 | KEGG: cbe:Cbei_0628 radical SAM domain-containing protein. (156 aa) |
| | Cpap_0244 | KEGG: cce:Ccel_0723 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (475 aa) |
| | Cpap_0286 | Radical SAM domain protein; KEGG: tjr:TherJR_2454 oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM domain protein; HemN domain protein; SMART: Elongator protein 3/MiaB/NifB. (434 aa) |
| | Cpap_0308 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (479 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: cce:Ccel_2914 carbamoyl-phosphate synthase, large subunit; SMART: MGS domain protein; Belongs to the CarB family. (1070 aa) |
| | carA | KEGG: cce:Ccel_2913 carbamoyl-phosphate synthase, small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (351 aa) |
| | Cpap_0370 | PFAM: Uncharacterised protein family YgbA; KEGG: cby:CLM_1511 hypothetical protein. (102 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (272 aa) |
| | Cpap_0397 | Hypothetical protein; Manually curated; KEGG: swo:Swol_1977 hypothetical protein. (101 aa) |
| | queA | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (340 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (373 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (605 aa) |
| | Cpap_0471 | Manually curated; PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: dth:DICTH_0827 GTP pyrophosphokinase (ATP:GTP 3'-pyrophosphotransferase)(ppGpp synthetase I) ((P)ppGpp synthetase); SMART: metal-dependent phosphohydrolase HD region. (169 aa) |
| | Cpap_0480 | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (242 aa) |
| | Cpap_0600 | KEGG: cce:Ccel_2015 hypothetical protein. (128 aa) |
| | Cpap_0609 | KEGG: cce:Ccel_2022 RNA polymerase, sigma 28 subunit, FliA/WhiG; TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 4 domain protein; sigma-70 region 2 domain protein; sigma-70 region 3 domain protein. (254 aa) |
| | Cpap_0636 | TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit domain protein; KEGG: cce:Ccel_2048 ATPase FliI/YscN; SMART: AAA ATPase. (436 aa) |
| | Cpap_0649 | RNA polymerase, sigma 28 subunit, SigG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (257 aa) |
| | Cpap_0650 | RNA polymerase, sigma 28 subunit, SigE; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (243 aa) |
| | Cpap_0657 | PFAM: domain of unknown function DUF1727; Mur ligase middle domain protein; KEGG: cce:Ccel_2069 domain of unknown function DUF1727. (467 aa) |
| | Cpap_0658 | PFAM: CobB/CobQ domain protein glutamine amidotransferase; KEGG: cce:Ccel_2070 CobB/CobQ domain protein glutamine amidotransferase. (248 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (208 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (896 aa) |
| | Cpap_0665 | KEGG: cce:Ccel_2077 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (198 aa) |
| | Cpap_0667 | KEGG: cth:Cthe_0973 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase). (125 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (424 aa) |
| | Cpap_0837 | KEGG: cce:Ccel_2207 Cof-like hydrolase; TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase type 3. (273 aa) |
| | Cpap_0839 | PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: cce:Ccel_2205 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase. (248 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (511 aa) |
| | Cpap_0897 | KEGG: acl:ACL_0392 ECF subfamily RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (174 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (487 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: cce:Ccel_2183 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (340 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (207 aa) |
| | purH | SMART: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: cce:Ccel_2181 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein. (514 aa) |
| | purD | TIGRFAM: phosphoribosylamine/glycine ligase; KEGG: cce:Ccel_2180 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (419 aa) |
| | Cpap_0944 | KEGG: cce:Ccel_2164 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (188 aa) |
| | Cpap_0962 | PFAM: Dockerin type 1; KEGG: cce:Ccel_0417 cellulosome protein dockerin type I. (848 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (213 aa) |
| | Cpap_0998 | PFAM: Radical SAM domain protein; KEGG: gem:GM21_3455 radical SAM domain protein. (454 aa) |
| | Cpap_1003 | Hypothetical protein; KEGG: csc:Csac_0653 arylsulfatase regulator (Fe-S oxidoreductase)-like protein. (375 aa) |
| | Cpap_1025 | RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; PFAM: sigma-70 region 2 domain protein; KEGG: cth:Cthe_1012 sporulation sigma factor SigK. (138 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa) |
| | polC | DNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1433 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (382 aa) |
| | Cpap_1056 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; KEGG: cce:Ccel_0461 riboflavin biosynthesis protein RibF; SMART: Riboflavin kinase; Belongs to the ribF family. (311 aa) |
| | Cpap_1094 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: cce:Ccel_0499 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (1256 aa) |
| | Cpap_1114 | RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: ere:EUBREC_3107 hypothetical protein; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (179 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (323 aa) |
| | Cpap_1251 | KEGG: bbe:BBR47_11560 hypothetical protein. (328 aa) |
| | Cpap_1252 | RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: ckr:CKR_1934 hypothetical protein; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (188 aa) |
| | Cpap_1291 | AAA ATPase; KEGG: cyp:PCC8801_0629 AAA ATPase. (429 aa) |
| | Cpap_1320 | KEGG: cce:Ccel_0803 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (184 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (315 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | Cpap_1407 | Pyruvate dehydrogenase (acetyl-transferring); KEGG: cce:Ccel_3450 dehydrogenase E1 component; PFAM: dehydrogenase E1 component. (321 aa) |
| | Cpap_1439 | TIGRFAM: nicotinate-nucleotide pyrophosphorylase; KEGG: cce:Ccel_3478 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (278 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (226 aa) |
| | Cpap_1445 | KEGG: pmu:PM0185 hypothetical protein. (154 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (249 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | pyrR | Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (178 aa) |
| | pyrB | KEGG: cce:Ccel_0612 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa) |
| | pyrF | TIGRFAM: orotidine 5'-phosphate decarboxylase; KEGG: cce:Ccel_0614 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (312 aa) |
| | carA-2 | KEGG: cce:Ccel_0615 carbamoyl-phosphate synthase, small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (360 aa) |
| | carB-2 | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: cce:Ccel_0616 carbamoyl phosphate synthase large subunit; SMART: MGS domain protein; Belongs to the CarB family. (1071 aa) |
| | Cpap_1596 | PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; Oxidoreductase FAD-binding domain protein; oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: cce:Ccel_0617 oxidoreductase FAD/NAD(P)-binding domain protein. (258 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (307 aa) |
| | Cpap_1599 | KEGG: cce:Ccel_0620 hypothetical protein. (285 aa) |
| | Cpap_1613 | PFAM: C_GCAxxG_C_C family protein; KEGG: cce:Ccel_0632 hypothetical protein. (115 aa) |
| | Cpap_1621 | KEGG: cce:Ccel_0634 hypothetical protein. (176 aa) |
| | Cpap_1630 | Adenosylcobinamide-phosphate guanylyltransferase; PFAM: cobalbumin biosynthesis protein; KEGG: cce:Ccel_0644 cobalbumin biosynthesis protein; SMART: AAA ATPase. (190 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (250 aa) |
| | cobT | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (352 aa) |
| | Cpap_1641 | KEGG: drm:Dred_2992 RNA polymerase, sigma 54 subunit, RpoN; TIGRFAM: RNA polymerase sigma-54 factor, RpoN; PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor; sigma-54 factor core-binding region. (452 aa) |
| | cinA | TIGRFAM: competence/damage-inducible protein CinA; molybdenum cofactor synthesis domain protein; PFAM: CinA domain protein; molybdopterin binding domain; KEGG: cce:Ccel_0674 competence/damage-inducible protein CinA; SMART: molybdopterin binding domain. (415 aa) |
| | Cpap_1675 | Hypothetical protein; Manually curated; KEGG: swo:Swol_1977 hypothetical protein. (99 aa) |
| | Cpap_1724 | C_GCAxxG_C_C family protein; KEGG: mpd:MCP_2169 hypothetical protein; TIGRFAM: C_GCAxxG_C_C family protein; PFAM: C_GCAxxG_C_C family protein. (147 aa) |
| | Cpap_1755 | Salicylate synthase; KEGG: dae:Dtox_2676 AMP-dependent synthetase and ligase; TIGRFAM: salicylate synthase; PFAM: Chorismate binding-like. (450 aa) |
| | Cpap_1760 | KEGG: ele:Elen_2307 hypothetical protein; TIGRFAM: conserved hypothetical protein; PFAM: Conserved hypothetical CHP02185, integral membrane. (193 aa) |
| | Cpap_1785 | SMART: beta-lactamase domain protein; KEGG: dae:Dtox_1747 beta-lactamase domain protein. (275 aa) |
| | Cpap_1820 | KEGG: cth:Cthe_2968 4Fe-4S ferredoxin, iron-sulfur binding. (275 aa) |
| | Cpap_1827 | KEGG: pjd:Pjdr2_2342 hypothetical protein. (162 aa) |
| | Cpap_1842 | KEGG: cce:Ccel_1538 thiamine pyrophosphokinase; TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic domain-containing protein. (211 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (818 aa) |
| | Cpap_1873 | RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: ctc:CTC00618 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. ECF subfamily. (155 aa) |
| | Cpap_1883 | KEGG: cce:Ccel_0228 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (181 aa) |
| | Cpap_1890 | KEGG: cce:Ccel_0233 C_GCAxxG_C_C family protein; TIGRFAM: C_GCAxxG_C_C family protein; PFAM: C_GCAxxG_C_C family protein. (156 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (562 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (236 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (74 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (161 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (175 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (505 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (294 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (464 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (134 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (179 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1246 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1165 aa) |
| | Cpap_2035 | TIGRFAM: DNA polymerase LigD, polymerase domain protein; KEGG: cce:Ccel_0366 DNA polymerase LigD, polymerase domain protein. (303 aa) |
| | Cpap_2044 | KEGG: cce:Ccel_0375 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (204 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: cce:Ccel_0385 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (298 aa) |
| | Cpap_2063 | PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; KEGG: cce:Ccel_0394 inosine 5-monophosphate dehydrogenase; SMART: CBS domain containing protein. (500 aa) |
| | Cpap_2069 | KEGG: cce:Ccel_0400 RNA polymerase, sigma 28 subunit, Sig B/F/G subfamily; TIGRFAM: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 3 domain protein; sigma-70 region 4 domain protein. (249 aa) |
| | Cpap_2082 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa) |
| | Cpap_2153 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (446 aa) |
| | Cpap_2155 | TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: cce:Ccel_0084 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (206 aa) |
| | Cpap_2238 | PFAM: DNA polymerase III delta; KEGG: cce:Ccel_0159 DNA polymerase III, delta prime subunit. (322 aa) |
| | Cpap_2256 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (167 aa) |
| | Cpap_2299 | PFAM: NGN domain-containing protein; KOW domain protein; KEGG: cce:Ccel_0204 NusG antitermination factor. (176 aa) |
| | Cpap_2304 | KEGG: cce:Ccel_0211 hypothetical protein. (366 aa) |
| | murA-2 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (421 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (691 aa) |
| | Cpap_2454 | RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: cce:Ccel_3319 RNA polymerase factor sigma-70; TIGRFAM: RNA polymerase sigma-H factor; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (214 aa) |
| | Cpap_2455 | KEGG: cpy:Cphy_1217 hypothetical protein. (128 aa) |
| | Cpap_2470 | PFAM: RelA/SpoT domain protein; KEGG: cce:Ccel_3227 RelA/SpoT domain protein. (230 aa) |
| | Cpap_2471 | RNA polymerase, sigma-24 subunit, ECF subfamily; Manually curated; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; KEGG: cbe:Cbei_1302 ECF subfamily RNA polymerase sigma-24 factor; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (187 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpF | KEGG: cce:Ccel_3217 N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (205 aa) |
| | trpC | KEGG: cce:Ccel_3216 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (488 aa) |
| | Cpap_2512 | Radical SAM domain protein; KEGG: cce:Ccel_3189 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; biotin and thiamin synthesis associated. (345 aa) |
| | Cpap_2513 | KEGG: cce:Ccel_3188 phosphopantothenoylcysteine decarboxylase; PFAM: flavoprotein. (178 aa) |
| | Cpap_2514 | PFAM: DNA/pantothenate metabolism flavoprotein domain protein; KEGG: cce:Ccel_3187 phosphopantothenate--cysteine ligase. (264 aa) |
| | Cpap_2518 | TIGRFAM: seryl-tRNA synthetase; KEGG: cce:Ccel_3183 seryl-tRNA synthetase; PFAM: Seryl-tRNA synthetase, class IIa-like; tRNA synthetase class II (G H P and S). (425 aa) |
| | Cpap_2535 | KEGG: cce:Ccel_3104 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SMART: biotin and thiamin synthesis associated; Elongator protein 3/MiaB/NifB. (470 aa) |
| | Cpap_2546 | Transferase hexapeptide repeat containing protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (390 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | Cpap_2585 | PFAM: aminotransferase class-III; KEGG: mst:Msp_1180 glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (440 aa) |
| | Cpap_2586 | PFAM: aminotransferase class-III; KEGG: fnu:FN0540 glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (440 aa) |
| | Cpap_2616 | KEGG: cce:Ccel_2510 protein of unknown function DUF201; manually curated; PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp. (449 aa) |
| | tmk-2 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (230 aa) |
| | Cpap_2654 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; KEGG: cce:Ccel_2546 ferredoxin-NADP(+) reductase subunit alpha. (281 aa) |
| | Cpap_2713 | Hypothetical protein; KEGG: cpy:Cphy_3141 iron-sulfur cluster-binding protein. (227 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (432 aa) |
| | Cpap_2736 | TIGRFAM: modD protein; KEGG: clj:CLJU_c38070 nicotinate-nucleotide diphosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (280 aa) |
| | Cpap_2793 | PFAM: phosphate acetyl/butaryl transferase; KEGG: shi:Shel_11220 phosphotransacetylase. (333 aa) |
| | Cpap_2843 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (480 aa) |
| | Cpap_2844 | PFAM: isochorismatase hydrolase; KEGG: cpy:Cphy_1765 isochorismatase hydrolase. (221 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (413 aa) |
| | Cpap_2874 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa) |
| | Cpap_2875 | TIGRFAM: riboflavin synthase, alpha subunit; KEGG: cce:Ccel_2005 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. (218 aa) |
| | ribBA | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (420 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa) |
| | Cpap_2887 | KEGG: cce:Ccel_1992 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (270 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (436 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (273 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (210 aa) |
| | Cpap_2898 | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (380 aa) |
| | Cpap_2904 | Radical SAM domain protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (346 aa) |
| | Cpap_2937 | KEGG: cce:Ccel_1954 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta. (338 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (171 aa) |
| | Cpap_2942 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (726 aa) |
| | Cpap_2945 | Coproporphyrinogen dehydrogenase; PFAM: Radical SAM domain protein; KEGG: cce:Ccel_1948 coproporphyrinogen III oxidase; SMART: Elongator protein 3/MiaB/NifB. (497 aa) |
| | Cpap_2956 | KEGG: mvo:Mvol_0238 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (383 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (145 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (623 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (286 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (189 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (292 aa) |
| | Cpap_3093 | PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: cce:Ccel_1803 metal dependent phosphohydrolase; SMART: metal-dependent phosphohydrolase HD region. (196 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (68 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | sigI | RNA polymerase, sigma 28 subunit, SigI; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; Belongs to the sigma-70 factor family. SigI subfamily. (256 aa) |
| | Cpap_3162 | PFAM: carboxyl transferase; KEGG: cce:Ccel_1738 carboxyl transferase. (516 aa) |
| | cmk | KEGG: cce:Ccel_1729 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (223 aa) |
| | Cpap_3177 | PFAM: amino acid-binding ACT domain protein; KEGG: cce:Ccel_1723 hypothetical protein; Belongs to the UPF0237 family. (89 aa) |
| | thiI | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (391 aa) |
| | Cpap_3285 | KEGG: cbe:Cbei_0313 ECF subfamily RNA polymerase sigma-24 factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (188 aa) |
| | Cpap_3344 | PFAM: Protein of unknown function DUF3343; KEGG: amt:Amet_4104 radical SAM domain-containing protein. (89 aa) |
| | Cpap_3351 | PFAM: thymidylate kinase; KEGG: cce:Ccel_2513 thymidylate kinase-like protein. (233 aa) |
| | cbiM | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (248 aa) |
| | cbiN | Cobalt transport protein CbiN; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (97 aa) |
| | cbiD | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (384 aa) |
| | Cpap_3367 | KEGG: cce:Ccel_1271 precorrin-2 C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. (226 aa) |
| | Cpap_3368 | TIGRFAM: precorrin-4 C11-methyltransferase; KEGG: cce:Ccel_1272 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (251 aa) |
| | Cpap_3369 | PFAM: Cobalamin synthesis G-like; cobalamin (vitamin B12) biosynthesis CbiG protein; Cobalamin biosynthesis central region; KEGG: cce:Ccel_1273 cobalamin (vitamin B12) biosynthesis CbiG protein. (340 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (336 aa) |
| | Cpap_3371 | KEGG: cce:Ccel_1275 precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (244 aa) |
| | Cpap_3372 | KEGG: cce:Ccel_1276 precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; siroheme synthase; PFAM: Precorrin-6x reductase CbiJ/CobK. (407 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (297 aa) |
| | Cpap_3374 | KEGG: cce:Ccel_1278 uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrinogen III synthase HEM4; Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (504 aa) |
| | Cpap_3375 | Porphobilinogen synthase; KEGG: cce:Ccel_1279 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (325 aa) |
| | hemL | KEGG: cce:Ccel_1280 glutamate-1-semialdehyde-2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III. (434 aa) |
| | Cpap_3377 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: cce:Ccel_1281 cobalamin (vitamin B12) biosynthesis CbiX protein. (120 aa) |
| | Cpap_3378 | TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; KEGG: cce:Ccel_1282 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein of unknown function Met10. (395 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (458 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (504 aa) |
| | Cpap_3381 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: cce:Ccel_1285 precorrin-8X methylmutase CbiC/CobH. (211 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (322 aa) |
| | Cpap_3405 | PFAM: RNA-directed DNA polymerase (Reverse transcriptase); KEGG: spc:Sputcn32_2611 retron-type reverse transcriptase. (348 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | Cpap_3415 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (160 aa) |
| | dinB-2 | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (399 aa) |
| | Cpap_3433 | KEGG: cce:Ccel_1327 4Fe-4S ferredoxin iron-sulfur binding domain protein. (229 aa) |
| | folE | TIGRFAM: GTP cyclohydrolase I; KEGG: cce:Ccel_1328 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. (194 aa) |
| | Cpap_3436 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (274 aa) |
| | Cpap_3437 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (124 aa) |
| | Cpap_3438 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; KEGG: cce:Ccel_1332 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (157 aa) |
| | Cpap_3439 | PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; KEGG: cce:Ccel_1333 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. (177 aa) |
| | Cpap_3450 | PFAM: GCN5-related N-acetyltransferase; KEGG: cbe:Cbei_3415 GCN5-related N-acetyltransferase. (152 aa) |
| | Cpap_3456 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: cbe:Cbei_2463 cobalamin synthesis protein, P47K. (325 aa) |
| | Cpap_3474 | PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein; KEGG: ckr:CKR_2210 cobalt transport protein CbiM. (333 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (171 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (200 aa) |
| | Cpap_3520 | TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: cce:Ccel_1364 metal dependent phosphohydrolase; SMART: metal-dependent phosphohydrolase HD region. (193 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa) |
| | Cpap_3644 | KEGG: cce:Ccel_1447 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; Belongs to the folylpolyglutamate synthase family. (424 aa) |
| | Cpap_3656 | DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: cce:Ccel_1459 DNA polymerase III DnaE; PFAM: DNA polymerase III alpha subunit; nucleic acid binding OB-fold tRNA/helicase-type; PHP domain protein. (1158 aa) |
| | Cpap_3657 | PFAM: tryptophan RNA-binding attenuator protein; KEGG: cce:Ccel_1460 transcription attenuation protein MtrB. (77 aa) |
| | Cpap_3698 | KEGG: cce:Ccel_0932 carbamoyl-phosphate synthase L chain ATP-binding; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein; Carbamoyl-phosphate synthetase large chain domain protein; SMART: biotin carboxylase domain protein. (513 aa) |
| | Cpap_3700 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (458 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (260 aa) |
| | Cpap_3726 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: sti:Sthe_0801 UBA/ThiF-type NAD/FAD binding protein. (339 aa) |
| | Cpap_3751 | PFAM: pyridoxamine 5'-phosphate oxidase-related FMN-binding; KEGG: cac:CA_C2569 NimC/NimA family protein. (131 aa) |
| | Cpap_3786 | PFAM: purine or other phosphorylase family 1; KEGG: cce:Ccel_1081 purine or other phosphorylase family 1. (252 aa) |
| | Cpap_4236 | KEGG: dhd:Dhaf_2886 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (162 aa) |
| | Cpap_4159 | RNA polymerase, sigma 28 subunit, SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (248 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (291 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (642 aa) |
| | Cpap_3863 | KEGG: cbe:Cbei_1518 thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein. (64 aa) |
| | Cpap_3862 | KEGG: amt:Amet_4236 thiamine biosynthesis protein ThiF; TIGRFAM: thiamine biosynthesis protein ThiF; PFAM: UBA/THIF-type NAD/FAD binding protein. (267 aa) |
| | Cpap_3861 | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (255 aa) |
| | Cpap_3860 | TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; KEGG: cbe:Cbei_1520 thiamine biosynthesis protein ThiH; SMART: biotin and thiamin synthesis associated. (382 aa) |
| | Cpap_3859 | PFAM: thiamine monophosphate synthase; KEGG: ctc:CTC01746 regulatory protein TenI. (227 aa) |
| | Cpap_3814 | PFAM: Radical SAM domain protein; KEGG: rpb:RPB_2071 radical SAM family protein. (356 aa) |
| | Cpap_3811 | KEGG: rpb:RPB_2071 radical SAM family protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (368 aa) |
| | Cpap_3789 | KEGG: cce:Ccel_1084 tryptophan synthase, alpha subunit; TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase alpha chain; Belongs to the TrpA family. (240 aa) |
