STRINGSTRING
Cpap_3863 Cpap_3863 Cpap_0100 Cpap_0100 ackA ackA Cpap_0166 Cpap_0166 Cpap_0186 Cpap_0186 Cpap_0188 Cpap_0188 Cpap_0232 Cpap_0232 Cpap_0600 Cpap_0600 Cpap_0725 Cpap_0725 Cpap_0741 Cpap_0741 bioB bioB Cpap_1189 Cpap_1189 Cpap_1407 Cpap_1407 Cpap_1501 Cpap_1501 folD folD Cpap_1701 Cpap_1701 Cpap_1702 Cpap_1702 Cpap_1703 Cpap_1703 gshA gshA Cpap_1842 Cpap_1842 metK metK metAA metAA Cpap_2448 Cpap_2448 Cpap_2455 Cpap_2455 Cpap_2512 Cpap_2512 Cpap_2515 Cpap_2515 Cpap_2535 Cpap_2535 Cpap_2616 Cpap_2616 Cpap_2722 Cpap_2722 Cpap_2756 Cpap_2756 Cpap_2793 Cpap_2793 Cpap_2887 Cpap_2887 thiC thiC thiM thiM thiE thiE dxs dxs Cpap_3162 Cpap_3162 thiI thiI Cpap_3344 Cpap_3344 mtnK mtnK mtnA mtnA Cpap_3477 Cpap_3477 Cpap_3478 Cpap_3478 Cpap_3514 Cpap_3514 Cpap_3649 Cpap_3649 Cpap_3698 Cpap_3698 Cpap_3700 Cpap_3700 accD accD accA accA Cpap_3810 Cpap_3810 Cpap_3859 Cpap_3859 Cpap_3860 Cpap_3860 Cpap_3861 Cpap_3861
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cpap_3863KEGG: cbe:Cbei_1518 thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein. (64 aa)
Cpap_0100TIGRFAM: phosphate acetyltransferase; KEGG: cce:Ccel_2137 phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase. (331 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
Cpap_0166KEGG: cce:Ccel_2752 hypothetical protein. (340 aa)
Cpap_0186PFAM: phosphoadenosine phosphosulfate reductase; KEGG: cbk:CLL_A2764 putative aminotransferase, class V. (332 aa)
Cpap_0188PFAM: phosphoadenosine phosphosulfate reductase; KEGG: clj:CLJU_c14570 hypothetical protein. (461 aa)
Cpap_0232PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ckr:CKR_0907 hypothetical protein. (303 aa)
Cpap_0600KEGG: cce:Ccel_2015 hypothetical protein. (128 aa)
Cpap_0725KEGG: cce:Ccel_2487 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; TIGRFAM: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: HAD-superfamily hydrolase subfamily IB hypothetical 1. (220 aa)
Cpap_0741PFAM: dihydropteroate synthase DHPS; KEGG: cce:Ccel_2473 dihydropteroate synthase DhpS. (261 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (323 aa)
Cpap_1189PFAM: LmbE family protein; KEGG: sus:Acid_0805 LmbE family protein. (282 aa)
Cpap_1407Pyruvate dehydrogenase (acetyl-transferring); KEGG: cce:Ccel_3450 dehydrogenase E1 component; PFAM: dehydrogenase E1 component. (321 aa)
Cpap_1501PFAM: phosphoadenosine phosphosulfate reductase; KEGG: pis:Pisl_1809 hypothetical protein. (313 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
Cpap_1701Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite. (240 aa)
Cpap_1702PFAM: phosphoadenosine phosphosulfate reductase; KEGG: cth:Cthe_2536 sulfate adenylyltransferase subunit 2. (293 aa)
Cpap_1703Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (585 aa)
gshAPFAM: glutamate--cysteine ligase; KEGG: cce:Ccel_1557 glutamate--cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (496 aa)
Cpap_1842KEGG: cce:Ccel_1538 thiamine pyrophosphokinase; TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic domain-containing protein. (211 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (396 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (306 aa)
Cpap_2448TIGRFAM: serine O-acetyltransferase; KEGG: cce:Ccel_3325 serine O-acetyltransferase. (235 aa)
Cpap_2455KEGG: cpy:Cphy_1217 hypothetical protein. (128 aa)
Cpap_2512Radical SAM domain protein; KEGG: cce:Ccel_3189 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; biotin and thiamin synthesis associated. (345 aa)
Cpap_2515KEGG: cce:Ccel_3186 cysteine synthase A; TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa)
Cpap_2535KEGG: cce:Ccel_3104 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SMART: biotin and thiamin synthesis associated; Elongator protein 3/MiaB/NifB. (470 aa)
Cpap_2616KEGG: cce:Ccel_2510 protein of unknown function DUF201; manually curated; PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp. (449 aa)
Cpap_2722SMART: Semialdehyde dehydrogenase NAD - binding; TIGRFAM: aspartate-semialdehyde dehydrogenase; KEGG: cce:Ccel_2591 aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa)
Cpap_2756TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: ere:EUBREC_2200 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (286 aa)
Cpap_2793PFAM: phosphate acetyl/butaryl transferase; KEGG: shi:Shel_11220 phosphotransacetylase. (333 aa)
Cpap_2887KEGG: cce:Ccel_1992 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (270 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (436 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (273 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (210 aa)
dxsDeoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (623 aa)
Cpap_3162PFAM: carboxyl transferase; KEGG: cce:Ccel_1738 carboxyl transferase. (516 aa)
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (391 aa)
Cpap_3344PFAM: Protein of unknown function DUF3343; KEGG: amt:Amet_4104 radical SAM domain-containing protein. (89 aa)
mtnK5-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (409 aa)
mtnATranslation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (362 aa)
Cpap_3477PFAM: Vitamin B12 dependent methionine synthase activation region; KEGG: cth:Cthe_0644 vitamin B12 dependent methionine synthase, activation region. (217 aa)
Cpap_3478PFAM: homocysteine S-methyltransferase; dihydropteroate synthase DHPS; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: cth:Cthe_0645 methionine synthase (B12-dependent). (811 aa)
Cpap_3514MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (253 aa)
Cpap_3649PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: cce:Ccel_1452 homoserine dehydrogenase. (414 aa)
Cpap_3698KEGG: cce:Ccel_0932 carbamoyl-phosphate synthase L chain ATP-binding; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein; Carbamoyl-phosphate synthetase large chain domain protein; SMART: biotin carboxylase domain protein. (513 aa)
Cpap_3700acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (458 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (260 aa)
Cpap_3810PFAM: LmbE family protein; KEGG: mma:MM_2100 hypothetical protein. (235 aa)
Cpap_3859PFAM: thiamine monophosphate synthase; KEGG: ctc:CTC01746 regulatory protein TenI. (227 aa)
Cpap_3860TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; KEGG: cbe:Cbei_1520 thiamine biosynthesis protein ThiH; SMART: biotin and thiamin synthesis associated. (382 aa)
Cpap_3861Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (255 aa)
Your Current Organism:
Ruminiclostridium papyrosolvens DSM 2782
NCBI taxonomy Id: 588581
Other names: Clostridium papyrosolvens DSM 2782, R. papyrosolvens DSM 2782
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.