STRINGSTRING
SFI51757.1 SFI51757.1 SFI54647.1 SFI54647.1 ilvC ilvC glcB glcB SFI60189.1 SFI60189.1 SFI61448.1 SFI61448.1 SFI62886.1 SFI62886.1 SFI63855.1 SFI63855.1 SFI63893.1 SFI63893.1 SFI65120.1 SFI65120.1 pdhA pdhA SFI66470.1 SFI66470.1 SFI66506.1 SFI66506.1 pdhA-2 pdhA-2 eno eno SFI68510.1 SFI68510.1 SFI72286.1 SFI72286.1 SFI73693.1 SFI73693.1 fumC fumC SFI74380.1 SFI74380.1 SFI78563.1 SFI78563.1 SFI80449.1 SFI80449.1 SFI80517.1 SFI80517.1 SFI80552.1 SFI80552.1 SFI86112.1 SFI86112.1 SFI90471.1 SFI90471.1 SFI90507.1 SFI90507.1 SFI92103.1 SFI92103.1 SFJ03752.1 SFJ03752.1 SFJ04408.1 SFJ04408.1 SFJ04456.1 SFJ04456.1 SFJ05303.1 SFJ05303.1 SFJ05336.1 SFJ05336.1 SFJ06725.1 SFJ06725.1 SFJ06766.1 SFJ06766.1 SFJ17572.1 SFJ17572.1 ldh ldh SFJ19449.1 SFJ19449.1 SFJ19660.1 SFJ19660.1 SFJ22336.1 SFJ22336.1 SFJ34153.1 SFJ34153.1 SFJ34205.1 SFJ34205.1 SFJ34237.1 SFJ34237.1 SFJ34265.1 SFJ34265.1 mdh mdh sucC sucC sucD sucD SFJ34635.1 SFJ34635.1 SFJ34665.1 SFJ34665.1 SFJ34713.1 SFJ34713.1 SFJ35915.1 SFJ35915.1 SFJ35956.1 SFJ35956.1 SFJ35997.1 SFJ35997.1 SFJ39408.1 SFJ39408.1 ackA ackA SFJ43689.1 SFJ43689.1 SFJ50522.1 SFJ50522.1 SFJ53324.1 SFJ53324.1 SFJ53354.1 SFJ53354.1 SFJ54044.1 SFJ54044.1 ilvD ilvD ilvE ilvE SFJ55425.1 SFJ55425.1 SFJ55462.1 SFJ55462.1 SFJ58957.1 SFJ58957.1 SFJ67885.1 SFJ67885.1 SFJ70607.1 SFJ70607.1 SFJ70632.1 SFJ70632.1 SFJ70663.1 SFJ70663.1 SFJ72026.1 SFJ72026.1 SFJ79237.1 SFJ79237.1 SFJ80111.1 SFJ80111.1 SFJ84253.1 SFJ84253.1 SFJ84472.1 SFJ84472.1 SFJ86971.1 SFJ86971.1 SFJ90590.1 SFJ90590.1 leuA leuA SFJ92015.1 SFJ92015.1 SFJ93246.1 SFJ93246.1 SFJ93280.1 SFJ93280.1 SFJ95045.1 SFJ95045.1 SFJ95266.1 SFJ95266.1 SFJ95769.1 SFJ95769.1 SFJ96110.1 SFJ96110.1 SFJ96435.1 SFJ96435.1 SFJ97169.1 SFJ97169.1 SFK01134.1 SFK01134.1 SFK03956.1 SFK03956.1 SFK03987.1 SFK03987.1 SFK06298.1 SFK06298.1 leuC leuC leuD leuD leuB leuB pckA pckA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFI51757.1Antitoxin CptB. (96 aa)
SFI54647.1Pyruvate, orthophosphate dikinase. (852 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (717 aa)
SFI60189.1Methylmalonate-semialdehyde dehydrogenase [acylating]. (499 aa)
SFI61448.1Citrate synthase; Belongs to the citrate synthase family. (432 aa)
SFI62886.1Dihydrolipoamide dehydrogenase. (465 aa)
SFI63855.1Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (895 aa)
SFI63893.1Aconitase. (929 aa)
SFI65120.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (393 aa)
pdhA2-oxoisovalerate dehydrogenase E1 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (665 aa)
SFI66470.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (446 aa)
SFI66506.1Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (458 aa)
pdhA-2Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (341 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
SFI68510.13-hydroxyisobutyrate dehydrogenase. (297 aa)
SFI72286.13-hydroxyisobutyrate dehydrogenase. (290 aa)
SFI73693.12-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (541 aa)
fumCFumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
SFI74380.1Putative quinone oxidoreductase, YhdH/YhfP family. (330 aa)
SFI78563.1Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (479 aa)
SFI80449.1Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (540 aa)
SFI80517.14-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (424 aa)
SFI80552.1Succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (484 aa)
SFI86112.1Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
SFI90471.1Acetolactate synthase, large subunit. (582 aa)
SFI90507.1Acetolactate synthase, small subunit. (188 aa)
SFI92103.1Acetyl-coenzyme A synthetase N-terminus; Partial gene; manually curated. (279 aa)
SFJ03752.1AMP-binding enzyme C-terminal domain-containing protein. (121 aa)
SFJ04408.1Dihydropyrimidine dehydrogenase (NAD+) subunit PreA. (433 aa)
SFJ04456.1Glutamate synthase (NADPH/NADH) small chain. (445 aa)
SFJ05303.1NADPH-dependent glutamate synthase beta chain. (556 aa)
SFJ05336.1Pyruvate-ferredoxin/flavodoxin oxidoreductase. (1210 aa)
SFJ06725.1Sulfoacetaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (496 aa)
SFJ06766.1Taurine-pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
SFJ17572.1D-lactate dehydrogenase (cytochrome). (455 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (310 aa)
SFJ19449.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa)
SFJ19660.1Hypothetical protein. (646 aa)
SFJ22336.1Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. (481 aa)
SFJ34153.1Succinate dehydrogenase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
SFJ34205.1Succinate dehydrogenase subunit A; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (602 aa)
SFJ34237.1Succinate dehydrogenase / fumarate reductase membrane anchor subunit. (123 aa)
SFJ34265.1Succinate dehydrogenase subunit C. (129 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
sucCsuccinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
SFJ34635.12-oxoglutarate dehydrogenase E1 component. (989 aa)
SFJ34665.12-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (500 aa)
SFJ34713.1Dihydrolipoamide dehydrogenase. (464 aa)
SFJ35915.1Transcriptional regulator, AraC family. (280 aa)
SFJ35956.1Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (346 aa)
SFJ35997.1Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (778 aa)
SFJ39408.1Phosphate butyryltransferase. (466 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (387 aa)
SFJ43689.1Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. (465 aa)
SFJ50522.1Glutamate synthase domain-containing protein 2; Belongs to the glutamate synthase family. (517 aa)
SFJ53324.1NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family. (251 aa)
SFJ53354.1Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (569 aa)
SFJ54044.1Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (576 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (614 aa)
ilvEBranched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (289 aa)
SFJ55425.1Glutamate synthase (NADPH/NADH) large chain. (1511 aa)
SFJ55462.1Glutamate synthase (NADPH) small subunit. (477 aa)
SFJ58957.1Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). (754 aa)
SFJ67885.14-aminobutyrate---pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa)
SFJ70607.1N-methylglutamate synthase subunit A. (296 aa)
SFJ70632.1N-methylglutamate synthase subunit B. (232 aa)
SFJ70663.1N-methylglutamate synthase subunit C precursor; Belongs to the glutamate synthase family. (441 aa)
SFJ72026.13-hydroxyisobutyrate dehydrogenase. (277 aa)
SFJ79237.1acetyl-CoA synthetase (ADP-forming). (701 aa)
SFJ80111.1Succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (482 aa)
SFJ84253.1D-alanine transaminase. (286 aa)
SFJ84472.1Pyruvate kinase; Belongs to the pyruvate kinase family. (482 aa)
SFJ86971.1AMP-binding enzyme. (161 aa)
SFJ90590.1Acetyl-coenzyme A synthetase N-terminus; Partial gene; manually curated. (281 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (525 aa)
SFJ92015.1L-lactate dehydrogenase (cytochrome). (381 aa)
SFJ93246.1Peptidase family M23. (308 aa)
SFJ93280.1succinyl-CoA:acetate CoA-transferase. (504 aa)
SFJ95045.1L-lactate dehydrogenase (cytochrome). (387 aa)
SFJ95266.1Coniferyl-aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (465 aa)
SFJ95769.1Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (112 aa)
SFJ96110.1Propane monooxygenase reductase subunit. (352 aa)
SFJ96435.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (790 aa)
SFJ97169.1Dihydrolipoamide dehydrogenase. (467 aa)
SFK01134.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (798 aa)
SFK03956.1propionyl-CoA synthetase. (630 aa)
SFK03987.1Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). (760 aa)
SFK06298.1Isocitrate dehydrogenase. (728 aa)
leuC3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
leuD3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (367 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (532 aa)
Your Current Organism:
Celeribacter neptunius
NCBI taxonomy Id: 588602
Other names: C. neptunius, CIP 109922, Celeribacter neptunius Ivanova et al. 2010, DSM 26471, KMM 6012, alpha proteobacterium H 14, strain H 14
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