(5 nodes) MCM domain network (Paramecium tetraurelia)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0CQF3_PARTE	MCM domain-containing protein; Belongs to the MCM family. (575 aa)
	A0D0Z9_PARTE	DNA helicase; Belongs to the MCM family. (791 aa)
	MCM7-2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (745 aa)
	A0DH93_PARTE	MCM domain-containing protein; Belongs to the MCM family. (810 aa)
	A0EBI9_PARTE	DNA helicase; Belongs to the MCM family. (697 aa)

Your Current Organism:

Paramecium tetraurelia

NCBI taxonomy Id: 5888
Other names: P. tetraurelia, Paramecium aurelia syngen 4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0CQF3_PARTE	A0D0Z9_PARTE	A0CQF3	A0D0Z9	MCM domain-containing protein; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
A0CQF3_PARTE	A0DH93_PARTE	A0CQF3	A0DH93	MCM domain-containing protein; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.999
A0CQF3_PARTE	A0EBI9_PARTE	A0CQF3	A0EBI9	MCM domain-containing protein; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
A0CQF3_PARTE	MCM7-2	A0CQF3	A0DAC7	MCM domain-containing protein; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
A0D0Z9_PARTE	A0CQF3_PARTE	A0D0Z9	A0CQF3	DNA helicase; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.999
A0D0Z9_PARTE	A0DH93_PARTE	A0D0Z9	A0DH93	DNA helicase; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.999
A0D0Z9_PARTE	A0EBI9_PARTE	A0D0Z9	A0EBI9	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
A0D0Z9_PARTE	MCM7-2	A0D0Z9	A0DAC7	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
A0DH93_PARTE	A0CQF3_PARTE	A0DH93	A0CQF3	MCM domain-containing protein; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.999
A0DH93_PARTE	A0D0Z9_PARTE	A0DH93	A0D0Z9	MCM domain-containing protein; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
A0DH93_PARTE	A0EBI9_PARTE	A0DH93	A0EBI9	MCM domain-containing protein; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
A0DH93_PARTE	MCM7-2	A0DH93	A0DAC7	MCM domain-containing protein; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
A0EBI9_PARTE	A0CQF3_PARTE	A0EBI9	A0CQF3	DNA helicase; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.999
A0EBI9_PARTE	A0D0Z9_PARTE	A0EBI9	A0D0Z9	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
A0EBI9_PARTE	A0DH93_PARTE	A0EBI9	A0DH93	DNA helicase; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.999
A0EBI9_PARTE	MCM7-2	A0EBI9	A0DAC7	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
MCM7-2	A0CQF3_PARTE	A0DAC7	A0CQF3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MCM domain-containing protein; Belongs to the MCM family.	0.999
MCM7-2	A0D0Z9_PARTE	A0DAC7	A0D0Z9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7-2	A0DH93_PARTE	A0DAC7	A0DH93	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MCM domain-containing protein; Belongs to the MCM family.	0.999
MCM7-2	A0EBI9_PARTE	A0DAC7	A0EBI9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999