STRINGSTRING
ANF54693.1 ANF54693.1 cysC cysC cysD cysD ANF53351.1 ANF53351.1 thiC thiC acsA acsA ANF53457.1 ANF53457.1 dxs dxs ANF53648.1 ANF53648.1 ANF53717.1 ANF53717.1 ANF53757.1 ANF53757.1 cysE cysE ANF53893.1 ANF53893.1 ANF53895.1 ANF53895.1 accA accA thiL thiL ANF54288.1 ANF54288.1 ANF54293.1 ANF54293.1 pdhA pdhA lipA lipA folD folD thiG thiG thiS thiS accC accC ANF54542.1 ANF54542.1 kbl kbl ANF54700.1 ANF54700.1 thiE thiE ANF55941.1 ANF55941.1 ANF54877.1 ANF54877.1 ANF55007.1 ANF55007.1 ANF55084.1 ANF55084.1 bioB bioB asd asd gshB gshB ANF56008.1 ANF56008.1 metK metK accD accD ANF55690.1 ANF55690.1 ANF56041.1 ANF56041.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ANF54693.1Omega amino acid--pyruvate aminotransferase; Catalyzes the formation of pyruvate and beta-alanine from L-alanine and 3-oxopropanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (440 aa)
cysCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (609 aa)
cysDSulfate adenylyltransferase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
ANF53351.1Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (453 aa)
thiCPhosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (603 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (627 aa)
ANF53457.1Cysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (636 aa)
ANF53648.1NADPH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
ANF53717.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
ANF53757.1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
cysESerine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
ANF53893.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (890 aa)
ANF53895.1Methylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (315 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (329 aa)
ANF54288.1Cysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
ANF54293.1Pyruvate dehydrogenase complex E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (451 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (342 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (324 aa)
folDBifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (307 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (262 aa)
thiSThiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
accCacetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
ANF54542.1O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (423 aa)
kblGlycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (396 aa)
ANF54700.1Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (582 aa)
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (219 aa)
ANF55941.1Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (612 aa)
ANF54877.1Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AB hydrolase superfamily. MetX family. (355 aa)
ANF55007.1Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
ANF55084.13-oxoacyl-ACP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
bioBBiotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (338 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa)
gshBGlutathione synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic GSH synthase family. (316 aa)
ANF56008.1Thiamine phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (411 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (299 aa)
ANF55690.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
ANF56041.1Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (573 aa)
Your Current Organism:
Brevundimonas naejangsanensis
NCBI taxonomy Id: 588932
Other names: B. naejangsanensis, Brevundimonas naejangsanensis Kang et al. 2009, CCUG 57609, DSM 23858, KCTC 22631, strain BIO-TAS2-2
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