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coaBC coaBC AJP42438.1 AJP42438.1 AJP42440.1 AJP42440.1 AJP42550.1 AJP42550.1 gpmA gpmA purU purU AJP42758.1 AJP42758.1 AJP42765.1 AJP42765.1 purK purK purA purA AJP42771.1 AJP42771.1 surE surE relA relA AJP42954.1 AJP42954.1 pgk pgk AJP43012.1 AJP43012.1 AJP43013.1 AJP43013.1 rdgB rdgB eno eno pyrG pyrG AJP43077.1 AJP43077.1 AJP43129.1 AJP43129.1 AJP43139.1 AJP43139.1 AJP43145.1 AJP43145.1 fliI fliI AJP43268.1 AJP43268.1 AJP43290.1 AJP43290.1 nadA nadA ppnK ppnK AJP43554.1 AJP43554.1 carB carB AJP43560.1 AJP43560.1 AJP43562.1 AJP43562.1 AJP43573.1 AJP43573.1 AJP43609.1 AJP43609.1 AJP43686.1 AJP43686.1 AJP43693.1 AJP43693.1 AJP43725.1 AJP43725.1 AJP43730.1 AJP43730.1 AJP43808.1 AJP43808.1 AJP43809.1 AJP43809.1 AJP43838.1 AJP43838.1 AJP43849.1 AJP43849.1 AJP43902.1 AJP43902.1 AJP43937.1 AJP43937.1 AJP43980.1 AJP43980.1 tesB tesB pyrD pyrD pyrF pyrF AJP44143.1 AJP44143.1 AJP44149.1 AJP44149.1 purC purC AJP44183.1 AJP44183.1 AJP44230.1 AJP44230.1 AJP44231.1 AJP44231.1 tmk tmk glk glk pyk pyk dcd dcd purF purF AJP44377.1 AJP44377.1 adk adk apt apt nadE nadE AJP44497.1 AJP44497.1 folD folD guaA guaA guaB guaB ndk ndk AJP44601.1 AJP44601.1 upp upp AJP44630.1 AJP44630.1 AJP44684.1 AJP44684.1 aceF aceF aceE aceE AJP44741.1 AJP44741.1 coaE coaE AJP44782.1 AJP44782.1 AJP44789.1 AJP44789.1 AJP44807.1 AJP44807.1 AJP44913.1 AJP44913.1 AJP44922.1 AJP44922.1 AJP45056.1 AJP45056.1 AJP45094.1 AJP45094.1 acs acs AJP45136.1 AJP45136.1 AJP45249.1 AJP45249.1 accC accC purH purH AJP45393.1 AJP45393.1 AJP45404.1 AJP45404.1 pyrE pyrE atpC atpC AJP45474.1 AJP45474.1 AJP45475.1 AJP45475.1 AJP45476.1 AJP45476.1 AJP45477.1 AJP45477.1 AJP45478.1 AJP45478.1 AJP45479.1 AJP45479.1 AJP45480.1 AJP45480.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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coaBCPhosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
AJP42438.1Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (213 aa)
AJP42440.1Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (702 aa)
AJP42550.1Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (196 aa)
gpmAPhosphoglyceromutase; 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
AJP42758.1Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
AJP42765.1N5-carboxyaminoimidazole ribonucleotide mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (378 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (367 aa)
AJP42771.1Adenylosuccinate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (57 aa)
surEStationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (247 aa)
relA(p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; Derived by automated computational analysis using gene prediction method: Protein Homology. (727 aa)
AJP42954.1Nucleoside triphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (391 aa)
AJP43012.1Fructose-1,6-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
AJP43013.1Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
rdgBNucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
enoEnolase; Catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
pyrGCTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; Derived by automated computational analysis using gene prediction method: Protein Homology. (543 aa)
AJP43077.1Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
AJP43129.1Uridylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
AJP43139.1acetyl-CoA carboxylase subunit alpha; Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
AJP43145.1Phosphoribosylformylglycinamidine synthase; Catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the FGAMS family. (1295 aa)
fliIATP synthase; Involved in type III protein export during flagellum assembly; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
AJP43268.1Thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
AJP43290.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (351 aa)
ppnKInorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (291 aa)
AJP43554.1Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
carBCarbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1073 aa)
AJP43560.1AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; also known to act on propionate; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
AJP43562.1Magnesium transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
AJP43573.1Thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
AJP43609.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)
AJP43686.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
AJP43693.1acyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
AJP43725.1Adenine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
AJP43730.1Septum formation inhibitor Maf; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
AJP43808.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
AJP43809.1Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa)
AJP43838.1Nicotinate-nucleotide adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
AJP43849.1Triosephosphate isomerase; Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
AJP43902.12-oxoglutarate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)
AJP43937.16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (331 aa)
AJP43980.1Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (551 aa)
tesBpalmitoyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (335 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
AJP44143.1Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
AJP44149.1Ribonucleotide-diphosphate reductase subunit beta; B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
AJP44183.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
AJP44230.15'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
AJP44231.1Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (206 aa)
glkGlucokinase; Catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial glucokinase family. (317 aa)
pykPyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (197 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa)
AJP44377.1acetyl-CoA carboxylase subunit beta; Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (178 aa)
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (277 aa)
AJP44497.1FMN adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (306 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
guaAGMP synthase; Contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
AJP44601.1Thymidine kinase; Catalyzes the formation of thymidine 5'-phosphate from thymidine; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
AJP44630.1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (657 aa)
AJP44684.1Methylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
aceFE2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; Derived by automated computational analysis using gene prediction method: Protein Homology. (677 aa)
aceEE1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; Derived by automated computational analysis using gene prediction method: Protein Homology. (891 aa)
AJP44741.1Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. (287 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (202 aa)
AJP44782.1Alkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (599 aa)
AJP44789.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (188 aa)
AJP44807.1Glucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (549 aa)
AJP44913.1Fructose-1,6-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
AJP44922.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
AJP45056.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (171 aa)
AJP45094.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
acsacetyl-CoA synthetase; Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (648 aa)
AJP45136.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
AJP45249.1Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (349 aa)
accCacetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (523 aa)
AJP45393.1Phosphoribosylamine--glycine ligase; Catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
AJP45404.1Xanthosine triphosphate pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
atpCATP synthase F0F1 subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (137 aa)
AJP45474.1ATP synthase F0F1 subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
AJP45475.1ATP F0F1 synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
AJP45476.1ATP F0F1 synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
AJP45477.1ATP F0F1 synthase subunit delta; Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
AJP45478.1ATP F0F1 synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
AJP45479.1ATP synthase subunit C; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
AJP45480.1ATP synthase F0F1 subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
Your Current Organism:
Alteromonas australica
NCBI taxonomy Id: 589873
Other names: A. australica, Alteromonas australica Ivanova et al. 2013, Alteromonas sp. H17, CIP 109921, KMM 6016, strain H 17
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