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| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (297 aa) |
| | Ferp_0062 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: afu:AF0935 homoserine dehydrogenase. (330 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa) |
| | pyrB | KEGG: afu:AF0106 aspartate carbamoyltransferase, catalytic subunit (PyrB); TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region. (298 aa) |
| | surE | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (262 aa) |
| | argG | KEGG: afu:AF2252 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (395 aa) |
| | Ferp_0277 | TIGRFAM: aspartate racemase; PFAM: Asp/Glu/hydantoin racemase; KEGG: pho:PH1733 aspartate racemase. (222 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (104 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; KEGG: afu:AF1274 carbamoyl-phosphate synthase, large (or ammonia) subunit (CarB); Belongs to the CarB family. (1081 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: afu:AF1273 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (358 aa) |
| | purC | KEGG: afu:AF1272 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (341 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (157 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (213 aa) |
| | Ferp_0381 | TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: afu:AF0080 acetylornithine aminotransferase (ArgD-1); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (378 aa) |
| | guaAB | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (304 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (337 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa) |
| | Ferp_0597 | PFAM: peptidase dimerisation domain protein; peptidase M20; KEGG: afu:AF0522 acetylornithine deacetylase. (322 aa) |
| | Ferp_0598 | KEGG: afu:AF2138 phosphoserine phosphatase (SerB); TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein. (391 aa) |
| | Ferp_0599 | PFAM: peptidase M24; creatinase; KEGG: sat:SYN_01652 Xaa-pro aminopeptidase. (372 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (151 aa) |
| | Ferp_0656 | PFAM: thymidylate synthase; KEGG: afu:AF2047 thymidylate synthase, putative. (424 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (280 aa) |
| | Ferp_0682 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: afu:AF0051 succinyl-diaminopimelate desuccinylase (DapE-1). (379 aa) |
| | leuC | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa) |
| | Ferp_0724 | KEGG: afu:AF1255 ornithine carbamoyltransferase; TIGRFAM: ornithine carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (305 aa) |
| | Ferp_0737 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (388 aa) |
| | Ferp_0766 | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: tpt:Tpet_1731 Glu/Leu/Phe/Val dehydrogenase, C terminal; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (411 aa) |
| | Ferp_0804 | KEGG: afu:AF0700 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (463 aa) |
| | guaAA | GMP synthase, small subunit; Catalyzes the synthesis of GMP from XMP. (183 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa) |
| | Ferp_0809 | TIGRFAM: LL-diaminopimelate aminotransferase; PFAM: aminotransferase class I and II; KEGG: afu:AF0409 LL-diaminopimelate aminotransferase. (384 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: afu:AF0883 argininosuccinate lyase (ArgH). (481 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (267 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (333 aa) |
| | Ferp_0943 | PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: afu:AF0528 cytochrome-c3 hydrogenase, subunit gamma. (233 aa) |
| | purD | KEGG: afu:AF1157 phosphoribosylamine--glycine ligase (PurD); TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (476 aa) |
| | Ferp_1101 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (219 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afu:AF0986 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (HisA-2). (237 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: afu:AF0985 imidazoleglycerol-phosphate dehydrogenase/histidinol-phosphatase (HisB). (186 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa) |
| | Ferp_1199 | PFAM: aminotransferase class I and II; KEGG: afu:AF2366 aspartate aminotransferase (AspB-1). (377 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (288 aa) |
| | Ferp_1292 | PFAM: deoxyUTP pyrophosphatase; KEGG: afu:AF1108 deoxyuridine 5'-triphosphate nucleotidohydrolase. (166 aa) |
| | Ferp_1297 | PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; KEGG: afu:AF1550 hypothetical protein. (212 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (430 aa) |
| | Ferp_1355 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: afu:AF2250 dihydroorotase. (401 aa) |
| | Ferp_1374 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: afu:AF1764 dCMP deaminase, putative. (149 aa) |
| | cimA | Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (489 aa) |
| | Ferp_1446 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: afu:AF0904 diaminopimelate aminotransferase. (399 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (755 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (270 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (271 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (389 aa) |
| | ilvD | KEGG: afu:AF1014 dihydroxy-acid dehydratase (IlvD); TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (546 aa) |
| | mfnA | Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (363 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: afu:AF2002 histidinol-phosphate aminotransferase (HisC-1). (344 aa) |
| | Ferp_1662 | PFAM: protein of unknown function DUF362; KEGG: afu:AF1306 hypothetical protein. (262 aa) |
| | Ferp_1663 | KEGG: afu:AF0789 hypothetical protein. (104 aa) |
| | Ferp_1664 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: afu:AF0949 glutamine synthetase (GlnA). (480 aa) |
| | Ferp_1665 | PFAM: ferredoxin-dependent glutamate synthase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mth:MTH194 glutamate synthase (NADPH), alpha subunit; Belongs to the glutamate synthase family. (479 aa) |
| | Ferp_1666 | PFAM: glutamate synthase alpha subunit domain protein; KEGG: mth:MTH192 tungsten formylmethanofuran dehydrogenase, subunit C-like protein. (234 aa) |
| | Ferp_1667 | PFAM: glutamine amidotransferase class-II; KEGG: mth:MTH191 glutamine PRPP amidotransferase. (305 aa) |
| | Ferp_1668 | PFAM: glutamine amidotransferase class-I; KEGG: afu:AF1277 hypothetical protein. (220 aa) |
| | hisC-2 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: afu:AF2024 histidinol-phosphate aminotransferase (HisC-2). (344 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (420 aa) |
| | Ferp_1774 | PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: afu:AF1647 hypothetical protein. (263 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (453 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (408 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa) |
| | Ferp_1994 | PFAM: Indole-3-glycerol phosphate synthase; KEGG: mae:Maeo_1115 indole-3-glycerol-phosphate synthase. (224 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (324 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (433 aa) |
| | Ferp_1997 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: mvn:Mevan_0330 anthranilate synthase component II. (186 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: pab:PAB2047 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (207 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (385 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (251 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (170 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (253 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (281 aa) |
| | hpt | Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (187 aa) |
| | Ferp_2111 | KEGG: afu:AF0813 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (527 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) |
| | Ferp_2126 | KEGG: afu:AF0628 multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (325 aa) |
| | katG | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (745 aa) |
| | Ferp_2162 | TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; KEGG: afu:AF1719 acetolactate synthase 3 regulatory subunit. (161 aa) |
| | Ferp_2163 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afu:AF1720 acetolactate synthase 3 catalytic subunit. (554 aa) |
| | Ferp_2213 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: afu:AF0551 threonine synthase. (404 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; KEGG: afu:AF1693 phosphoribosylaminoimidazole synthetase. (323 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (290 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (325 aa) |
| | aroD | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (204 aa) |
| | Ferp_2251 | PFAM: prephenate dehydratase; Chorismate mutase, type II; Prephenate dehydrogenase; amino acid-binding ACT domain protein; KEGG: afu:AF0227 chorismate mutase/prephenate dehydratase (PheA). (637 aa) |
| | tmk | TIGRFAM: thymidylate kinase; PFAM: thymidylate kinase; KEGG: afu:AF0061 thymidylate kinase (tmk). (204 aa) |
| | Ferp_2288 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: afu:AF0219 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (499 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (377 aa) |
| | glmS | Glucosamine/fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (591 aa) |
| | Ferp_2440 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; KEGG: afu:AF2242 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (450 aa) |
| | Ferp_2446 | PFAM: aminotransferase class I and II; KEGG: afu:AF2129 aspartate aminotransferase. (375 aa) |
| | Ferp_2451 | PFAM: asparagine synthase; KEGG: afu:AF1439 asparagine synthetase (AsnB). (385 aa) |
| | leuC-2 | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa) |
| | Ferp_2495 | PFAM: peptidase M24; KEGG: afu:AF2034 X-Pro aminopeptidase (PepQ); Belongs to the peptidase M24B family. (367 aa) |
| | hisE | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: hut:Huta_1413 phosphoribosyl-ATP diphosphatase. (92 aa) |
