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Ferp_0062 Ferp_0062 ilvE ilvE ilvC ilvC leuC leuC Ferp_0737 Ferp_0737 Ferp_0804 Ferp_0804 asd asd cimA cimA leuD leuD ilvD ilvD Ferp_2111 Ferp_2111 leuD-2 leuD-2 Ferp_2126 Ferp_2126 Ferp_2162 Ferp_2162 Ferp_2163 Ferp_2163 Ferp_2213 Ferp_2213 Ferp_2288 Ferp_2288 leuC-2 leuC-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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Ferp_0062PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: afu:AF0935 homoserine dehydrogenase. (330 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa)
leuCHomoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa)
Ferp_0737Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (388 aa)
Ferp_0804KEGG: afu:AF0700 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (463 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa)
cimAIsopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (489 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa)
ilvDKEGG: afu:AF1014 dihydroxy-acid dehydratase (IlvD); TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (546 aa)
Ferp_2111KEGG: afu:AF0813 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (527 aa)
leuD-23-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa)
Ferp_2126KEGG: afu:AF0628 multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (325 aa)
Ferp_2162TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; KEGG: afu:AF1719 acetolactate synthase 3 regulatory subunit. (161 aa)
Ferp_2163TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afu:AF1720 acetolactate synthase 3 catalytic subunit. (554 aa)
Ferp_2213TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: afu:AF0551 threonine synthase. (404 aa)
Ferp_2288TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: afu:AF0219 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (499 aa)
leuC-2Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa)
Your Current Organism:
Ferroglobus placidus
NCBI taxonomy Id: 589924
Other names: F. placidus DSM 10642, Ferroglobus placidus AEDII12DO, Ferroglobus placidus DSM 10642, Ferroglobus placidus str. DSM 10642, Ferroglobus placidus strain DSM 10642
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