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| | Ferp_0934 | PFAM: IMP biosynthesis enzyme PurP domain protein; IMP biosynthesis enzyme PurP; KEGG: afu:AF0256 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase-like protein. (376 aa) |
| | cofG | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (320 aa) |
| | Ferp_0012 | TIGRFAM: siroheme synthase; PFAM: TrkA-N domain protein; KEGG: afu:AF1592 hypothetical protein. (233 aa) |
| | lig | DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (555 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (297 aa) |
| | Ferp_0060 | TIGRFAM: methanogenesis marker protein 2; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: mtp:Mthe_0762 AIR synthase-like protein. (311 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa) |
| | pyrB | KEGG: afu:AF0106 aspartate carbamoyltransferase, catalytic subunit (PyrB); TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region. (298 aa) |
| | Ferp_0141 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; KEGG: afu:AF1645 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA/pantothenate metabolism flavoprotein domain protein; flavoprotein. (399 aa) |
| | Ferp_0142 | KEGG: afu:AF1646 hypothetical protein. (265 aa) |
| | Ferp_0155 | PFAM: Radical SAM domain protein; KEGG: mbu:Mbur_1265 radical SAM family Fe-S protein. (224 aa) |
| | Ferp_0168 | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (277 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (299 aa) |
| | Ferp_0170 | PFAM: aspartate dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mpl:Mpal_2777 aspartate dehydrogenase. (245 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (450 aa) |
| | Ferp_0208 | PFAM: DNA primase small subunit; KEGG: afu:AF2298 hypothetical protein. (269 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (207 aa) |
| | mptD | Protein of unknown function DUF381; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. (108 aa) |
| | tfe | Transcription factor TFIIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongatio [...] (175 aa) |
| | dnaG | TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (393 aa) |
| | rpoL | RNA polymerase dimerization; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (86 aa) |
| | Ferp_0275 | PFAM: RNA polymerase Rpb4; KEGG: afu:AF1530 hypothetical protein. (118 aa) |
| | rpoP | RNA polymerase Rbp10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (47 aa) |
| | Ferp_0316 | PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: afu:AF1275 hypothetical protein. (236 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; KEGG: afu:AF1274 carbamoyl-phosphate synthase, large (or ammonia) subunit (CarB); Belongs to the CarB family. (1081 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: afu:AF1273 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (358 aa) |
| | purC | KEGG: afu:AF1272 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (341 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (157 aa) |
| | Ferp_0328 | PFAM: Radical SAM domain protein; KEGG: hoh:Hoch_4243 radical SAM domain protein. (361 aa) |
| | Ferp_0339 | PFAM: Radical SAM domain protein; KEGG: mbu:Mbur_1951 radical SAM family Fe-S protein. (335 aa) |
| | mfnB | Protein of unknown function DUF556; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (234 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (213 aa) |
| | guaAB | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (304 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (531 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (337 aa) |
| | tfb | Transcription factor TFIIB cyclin-related protein; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (346 aa) |
| | Ferp_0598 | KEGG: afu:AF2138 phosphoserine phosphatase (SerB); TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein. (391 aa) |
| | Ferp_0608 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: afu:AF0721 hypothetical protein. (123 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (151 aa) |
| | thi4 | Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (257 aa) |
| | Ferp_0656 | PFAM: thymidylate synthase; KEGG: afu:AF2047 thymidylate synthase, putative. (424 aa) |
| | Ferp_0689 | PFAM: thiamineS protein; KEGG: tsi:TSIB_1624 hypothetical protein. (84 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (256 aa) |
| | Ferp_0752 | TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: MoeA domain protein domain I and II; molybdopterin binding domain; MoeA domain protein domain IV; KEGG: mfe:Mefer_1467 molybdenum cofactor synthesis domain protein. (534 aa) |
| | mptA | Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (305 aa) |
| | nusA | NusA family KH domain protein; Participates in transcription termination. Belongs to the NusA family. (139 aa) |
| | rpoA2 | DNA-directed RNA polymerase, subunit A'; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (376 aa) |
| | Ferp_0761 | DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (870 aa) |
| | Ferp_0762 | DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (604 aa) |
| | Ferp_0763 | PFAM: RNA polymerase beta subunit; RNA polymerase Rpb2 domain 2; RNA polymerase Rpb2 domain 3; KEGG: afu:AF1886 DNA-directed RNA polymerase subunit beta''; Belongs to the RNA polymerase beta chain family. (491 aa) |
| | rpoH | RNA polymerase Rpb5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (76 aa) |
| | Ferp_0788 | PFAM: AMP-dependent synthetase and ligase; KEGG: chy:CHY_0659 acetyl-CoA synthetase. (634 aa) |
| | Ferp_0792 | PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein; KEGG: nml:Namu_0755 rhodanese domain protein. (131 aa) |
| | guaAA | GMP synthase, small subunit; Catalyzes the synthesis of GMP from XMP. (183 aa) |
| | Ferp_0820 | KEGG: afu:AF0478 ATP-binding protein PhnP (PhnP). (252 aa) |
| | rpoD | RNA polymerase insert; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (262 aa) |
| | Ferp_0892 | TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: afu:AF1699 pyruvate ferredoxin oxidoreductase subunit gamma. (193 aa) |
| | Ferp_0893 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: afu:AF1700 pyruvate ferredoxin oxidoreductase, subunit delta (PorD). (97 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (255 aa) |
| | Ferp_0900 | PFAM: Transcription factor CBF/NF-Y/histone domain protein; KEGG: afu:AF1493 histone A1 (hpyA1-2). (69 aa) |
| | Ferp_0915 | TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region; KEGG: afu:AF2253 molybdopterin-guanine dinucleotide biosynthesis protein B (MobB). (158 aa) |
| | Ferp_0917 | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: afu:AF0116 uroporphyrinogen III synthase (HemD). (228 aa) |
| | Ferp_0919 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (229 aa) |
| | ribK | Transcriptional regulator, MarR family; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (215 aa) |
| | Ferp_0943 | PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: afu:AF0528 cytochrome-c3 hydrogenase, subunit gamma. (233 aa) |
| | Ferp_0949 | TIGRFAM: formate dehydrogenase family accessory protein FdhD; PFAM: formate dehydrogenase subunit FdhD; KEGG: afu:AF0372 hypothetical protein. (220 aa) |
| | tbp | TATA-box binding family protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (183 aa) |
| | Ferp_1003 | PFAM: acyl-CoA dehydrogenase domain protein; KEGG: afu:AF1293 acyl-CoA dehydrogenase (acd-9). (381 aa) |
| | purD | KEGG: afu:AF1157 phosphoribosylamine--glycine ligase (PurD); TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (476 aa) |
| | Ferp_1028 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (310 aa) |
| | Ferp_1034 | TIGRFAM: indolepyruvate ferredoxin oxidoreductase, beta subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: afu:AF2030 indolepyruvate ferredoxin oxidoreductase, subunit beta (IorB). (195 aa) |
| | Ferp_1086 | TIGRFAM: adenylyl cyclase CyaB; PFAM: adenylate cyclase; KEGG: afu:AF1988 hypothetical protein. (173 aa) |
| | polB | DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (488 aa) |
| | Ferp_1101 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (219 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa) |
| | Ferp_1134 | PFAM: aminotransferase class-III; KEGG: ape:APE_2130.1 glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (428 aa) |
| | cmk | TIGRFAM: cytidylate kinase; KEGG: afu:AF1900 cytidylate kinase. (178 aa) |
| | priL | DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (383 aa) |
| | Ferp_1229 | PFAM: Methyltransferase type 11; thiamineS protein; KEGG: hma:rrnB0259 cyclopropane-fatty-acyl-phospholipid synthase. (317 aa) |
| | Ferp_1249 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (292 aa) |
| | polC | DNA polymerase II, large subunit DP2; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1142 aa) |
| | Ferp_1263 | TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain; KEGG: afu:AF2251 competence-damage protein, putative. (221 aa) |
| | Ferp_1264 | KEGG: afu:AF2007 riboflavin-specific deaminase (RibG); TIGRFAM: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; PFAM: bifunctional deaminase-reductase domain protein. (225 aa) |
| | Ferp_1292 | PFAM: deoxyUTP pyrophosphatase; KEGG: afu:AF1108 deoxyuridine 5'-triphosphate nucleotidohydrolase. (166 aa) |
| | Ferp_1308 | Protein of unknown function DUF265; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (172 aa) |
| | Ferp_1311 | TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain; KEGG: afu:AF0265 molybdenum cofactor biosynthesis protein (MoaB). (167 aa) |
| | Ferp_1318 | KEGG: afu:AF2409 iron-sulfur cluster binding protein. (228 aa) |
| | Ferp_1321 | PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein; KEGG: deh:cbdb_A1349 rhodanese-like domain-containing protein. (132 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (430 aa) |
| | ctaB | UbiA prenyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (285 aa) |
| | cbiM | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (218 aa) |
| | cbiN | Cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (86 aa) |
| | Ferp_1355 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: afu:AF2250 dihydroorotase. (401 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (278 aa) |
| | Ferp_1379 | PFAM: Radical SAM domain protein; KEGG: afu:AF0577 hypothetical protein. (344 aa) |
| | Ferp_1386 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: afu:AF1125 heme biosynthesis protein (NirJ-1). (391 aa) |
| | tfb-2 | Transcription factor TFIIB cyclin-related protein; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (328 aa) |
| | Ferp_1404 | Transcription termination factor Tfs; KEGG: afu:AF1235 transcription-associated protein TFIIS; TIGRFAM: transcription factor S; PFAM: Transcription factor TFIIS; DNA-directed RNA polymerase, M/15 kDa subunit; SMART: Transcription factor TFIIS; DNA-directed RNA polymerase, M/15 kDa subunit; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (102 aa) |
| | Ferp_1429 | PFAM: Sjogrens syndrome scleroderma autoantigen 1; KEGG: afu:AF2370 hypothetical protein. (135 aa) |
| | Ferp_1434 | KEGG: rci:RCIX285 hypothetical protein. (126 aa) |
| | Ferp_1440 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: afu:AF0440 hypothetical protein. (112 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (224 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (243 aa) |
| | Ferp_1482 | KEGG: afu:AF0497 DNA polymerase B1 (PolB); TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. (785 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (755 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (270 aa) |
| | Ferp_1511 | PFAM: acyl-CoA dehydrogenase domain protein; KEGG: Hypothetical protein CBG15946; K00249 acyl-CoA dehydrogenase. (355 aa) |
| | Ferp_1521 | PFAM: Quinolinate phosphoribosyl transferase; KEGG: afu:AF0821 nicotinate phosphoribosyltransferase. (382 aa) |
| | Ferp_1528 | PFAM: Protein of unknown function DUF137; KEGG: iho:Igni_0452 hypothetical protein. (249 aa) |
| | Ferp_1551 | PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: afu:AF2363 hypothetical protein. (427 aa) |
| | Ferp_1566 | PFAM: acyl-CoA dehydrogenase domain protein; KEGG: afu:AF1026 acyl-CoA dehydrogenase (acd-7). (395 aa) |
| | Ferp_1579 | PFAM: acyl-CoA dehydrogenase domain protein; KEGG: afu:AF2057 acyl-CoA dehydrogenase (acd-10). (383 aa) |
| | mptE | Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (200 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (385 aa) |
| | Ferp_1622 | PFAM: Radical SAM domain protein; KEGG: tye:THEYE_A1314 AstB/ChuR-related protein. (358 aa) |
| | mfnA | Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (363 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A (MobA); Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (200 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (293 aa) |
| | Ferp_1627 | KEGG: mba:Mbar_A1191 hypothetical protein. (45 aa) |
| | Ferp_1629 | Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (172 aa) |
| | Ferp_1656 | KEGG: smr:Smar_0578 hypothetical protein. (503 aa) |
| | Ferp_1659 | PFAM: phosphoribulokinase/uridine kinase; KEGG: mtp:Mthe_1447 phosphoribulokinase/uridine kinase. (311 aa) |
| | ribL | Cytidyltransferase-related domain protein; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (152 aa) |
| | Ferp_1736 | PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; KEGG: afu:AF0276 hypothetical protein; Belongs to the UPF0284 family. (338 aa) |
| | Ferp_1746 | TIGRFAM: methyltransferase MtaA/CmuA family; PFAM: Uroporphyrinogen decarboxylase (URO-D); KEGG: mbu:Mbur_0808 methylcobalamin:coenzyme M methyltransferase. (341 aa) |
| | Ferp_1753 | PFAM: cobalamin adenosyltransferase; KEGG: afu:AF1290 hypothetical protein. (180 aa) |
| | Ferp_1758 | PFAM: Uroporphyrinogen decarboxylase (URO-D); KEGG: swo:Swol_0417 uroporphyrinogen decarboxylase. (343 aa) |
| | Ferp_1761 | TIGRFAM: methyltransferase MtaA/CmuA family; PFAM: Uroporphyrinogen decarboxylase (URO-D); KEGG: mba:Mbar_A3639 methylcobalamin:coenzyme M methyltransferase. (355 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (155 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (439 aa) |
| | Ferp_1769 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: afu:AF1974 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (321 aa) |
| | hemL | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: afu:AF1241 glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (415 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (292 aa) |
| | Ferp_1772 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: afu:AF1243 uroporphyrin-III C-methyltransferase (CysG-2); Belongs to the precorrin methyltransferase family. (267 aa) |
| | priS | DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (355 aa) |
| | Ferp_1795 | PFAM: Transcription factor CBF/NF-Y/histone domain protein; KEGG: afu:AF1493 histone A1 (hpyA1-2). (67 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (461 aa) |
| | purP | IMP biosynthesis enzyme PurP domain protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (356 aa) |
| | Ferp_1825 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mvn:Mevan_0815 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit. (83 aa) |
| | Ferp_1826 | TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: afu:AF2055 2-ketoisovalerate ferredoxin oxidoreductase, subunit gamma (VorG). (164 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (453 aa) |
| | Ferp_1878 | TIGRFAM: cobyrinic acid a,c-diamide synthase; PFAM: CobB/CobQ domain protein glutamine amidotransferase; Cobyrinic acid ac-diamide synthase; KEGG: mtp:Mthe_1001 cobyrinic acid a,c-diamide synthase. (426 aa) |
| | Ferp_1890 | PFAM: phosphoribosyltransferase; KEGG: afu:AF0386 orotate phosphoribosyltransferase-like protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (193 aa) |
| | Ferp_1936 | PFAM: ATP-NAD/AcoX kinase; KEGG: afu:AF0748 hypothetical protein. (298 aa) |
| | Ferp_1945 | PFAM: acyl-CoA dehydrogenase domain protein; KEGG: afu:AF1141 acyl-CoA dehydrogenase (acd-8). (390 aa) |
| | Ferp_1948 | TIGRFAM: molybdenum cofactor synthesis domain protein; MoaD family protein; PFAM: MoeA domain protein domain I and II; thiamineS protein; molybdopterin binding domain; MoeA domain protein domain IV; KEGG: mac:MA4087 molybdenum cofactor biosynthesis protein MoeA2. (467 aa) |
| | rpoK | RNA polymerase Rpb6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (73 aa) |
| | rpoN | RNA polymerase, N/8 Kd subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (72 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (227 aa) |
| | Ferp_1975 | KEGG: afu:AF2321 hypothetical protein. (179 aa) |
| | Ferp_1982 | PFAM: DRTGG domain protein; KEGG: afu:AF1212 hypothetical protein. (343 aa) |
| | Ferp_1994 | PFAM: Indole-3-glycerol phosphate synthase; KEGG: mae:Maeo_1115 indole-3-glycerol-phosphate synthase. (224 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (324 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (433 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: pab:PAB2047 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (207 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (385 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (251 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (333 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa) |
| | coaD | Cytidyltransferase-related domain protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. (148 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (274 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (170 aa) |
| | Ferp_2016 | KEGG: afu:AF2315 hypothetical protein; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain protein; PFAM: cytidylyltransferase. (168 aa) |
| | thiI | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (369 aa) |
| | Ferp_2102 | PFAM: Radical SAM domain protein; KEGG: ton:TON_1353 cmo tungsten-containing aldehyde ferredoxin oxidoreductase cofactor modifying protein. (355 aa) |
| | hpt | Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (187 aa) |
| | fae-hps | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (394 aa) |
| | Ferp_2131 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: afu:AF0422 uroporphyrin-III C-methyltransferase (CysG-1); Belongs to the precorrin methyltransferase family. (224 aa) |
| | Ferp_2142 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: afu:AF2208 hydroxymethylpyrimidine phosphate kinase (ThiD). (251 aa) |
| | Ferp_2204 | KEGG: afu:AF1416 riboflavin synthase; TIGRFAM: riboflavin synthase; PFAM: 67-dimethyl-8-ribityllumazine synthase. (152 aa) |
| | Ferp_2212 | TIGRFAM: MoaD family protein; PFAM: thiamineS protein; KEGG: pmx:PERMA_0222 MoaD family protein. (89 aa) |
| | Ferp_2225 | KEGG: afu:AF1117 DNA-directed RNA polymerase subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein. (188 aa) |
| | Ferp_2227 | Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (190 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; KEGG: afu:AF1693 phosphoribosylaminoimidazole synthetase. (323 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (301 aa) |
| | Ferp_2260 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: sto:ST0172 hypothetical protein. (207 aa) |
| | tmk | TIGRFAM: thymidylate kinase; PFAM: thymidylate kinase; KEGG: afu:AF0061 thymidylate kinase (tmk). (204 aa) |
| | Ferp_2273 | PFAM: ribosomal RNA adenine methylase transferase; KEGG: afu:AF0732 cobalamin biosynthesis precorrin-8W decarboxylase (CbiT). (165 aa) |
| | Ferp_2274 | PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: afu:AF0727 cobalamin biosynthesis precorrin-2 methyltransferase (CbiL). (200 aa) |
| | Ferp_2275 | PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: afu:AF0726 cobalamin biosynthesis precorrin-3 methylase (CbiF). (235 aa) |
| | Ferp_2276 | PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: afu:AF0725 cobalamin biosynthesis precorrin methylase (CbiG). (209 aa) |
| | Ferp_2277 | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: afu:AF0724 cobalamin biosynthesis precorrin-3 methylase (CbiH). (248 aa) |
| | Ferp_2278 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: mbu:Mbur_2355 precorrin-8X methylmutase. (199 aa) |
| | Ferp_2279 | PFAM: cobalamin (vitamin B12) biosynthesis CbiD protein; KEGG: afu:AF0723 cobalt-precorrin-6A synthase. (307 aa) |
| | Ferp_2280 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: afu:AF0722 cobalt-precorrin-6Y C(5)-methyltransferase. (180 aa) |
| | Ferp_2282 | PFAM: molybdopterin biosynthesis MoaE protein; KEGG: afu:AF2179 molybdopterin converting factor, subunit 2 (MoaE). (222 aa) |
| | atpD | V-type ATPase, D subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (210 aa) |
| | atpB | ATP synthase, B subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (462 aa) |
| | atpA | ATP synthase, A subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (573 aa) |
| | atpF | Vacuolar H+transporting two-sector ATPase F subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (101 aa) |
| | atpC | ATP synthase A1, C subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (346 aa) |
| | atpE | H+transporting two-sector ATPase E subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (185 aa) |
| | Ferp_2321 | TIGRFAM: reductive dehalogenase; KEGG: sil:SPO1738 dehalogenase, putative. (406 aa) |
| | Ferp_2329 | PFAM: acyl-CoA dehydrogenase domain protein; KEGG: rpe:RPE_3222 butyryl-CoA dehydrogenase. (380 aa) |
| | Ferp_2336 | TIGRFAM: MoaD family protein; PFAM: thiamineS protein; KEGG: pai:PAE2580 hypothetical protein. (98 aa) |
| | Ferp_2346 | PFAM: amine oxidase; KEGG: afu:AF1738 hypothetical protein. (401 aa) |
| | Ferp_2366 | KEGG: afu:AF0972 DNA polymerase III, subunit epsilon (DnaQ); TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease. (200 aa) |
| | Ferp_2375 | PFAM: Nucleotidyl transferase; transferase hexapeptide repeat containing protein; KEGG: deb:DehaBAV1_0505 nucleotidyl transferase. (402 aa) |
| | Ferp_2384 | Nucleotide sugar dehydrogenase; KEGG: afu:AF0596 UDP-glucose dehydrogenase (ugd-2); TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase. (422 aa) |
| | Ferp_2440 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; KEGG: afu:AF2242 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (450 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (142 aa) |
| | Ferp_2467 | PFAM: acyl-CoA dehydrogenase domain protein; KEGG: afu:AF0671 acyl-CoA dehydrogenase (acd-4). (415 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (428 aa) |
| | Ferp_2510 | KEGG: afu:AF0589 ribose-phosphate pyrophosphokinase (PrsA-1); TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family. (277 aa) |
| | mtnP | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (282 aa) |
| | Ferp_2530 | PFAM: phosphoribosyltransferase; KEGG: mma:MM_1262 xanthine-guanine phosphoribosyltransferase. (234 aa) |
