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| | Ferp_0001 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (411 aa) |
| | rnp4 | RNAse P, Rpr2/Rpp21 subunit; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (114 aa) |
| | Ferp_0020 | PFAM: plasmid stabilization system; KEGG: dae:Dtox_2458 addiction module toxin, RelE/StbE family. (86 aa) |
| | pfdA | Prefoldin, alpha subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. (139 aa) |
| | eif6 | Translation initiation factor eIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (218 aa) |
| | tatA | Twin-arginine translocation protein, TatA/E family subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (107 aa) |
| | Ferp_0097 | PFAM: ERCC4 domain protein; helix-hairpin-helix motif; SMART: Helix-hairpin-helix DNA-binding class 1; KEGG: afu:AF2418 DNA repair protein, putative. (213 aa) |
| | tatC | Sec-independent protein translocase, TatC subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. (236 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa) |
| | Ferp_0124 | PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; KEGG: afu:AF0176 molybdopterin oxidoreductase, molybdopterin binding subunit. (898 aa) |
| | Ferp_0136 | PFAM: Tetrahydromethanopterin S-methyltransferase MtrH subunit; KEGG: afu:AF0009 tetrahydromethanopterin S-methyltransferase subunit H. (277 aa) |
| | Ferp_0141 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; KEGG: afu:AF1645 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA/pantothenate metabolism flavoprotein domain protein; flavoprotein. (399 aa) |
| | nep1 | Suppressor Mra1 family protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (221 aa) |
| | Ferp_0199 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: afu:AF1064 ABC transporter, ATP-binding protein, putative. (614 aa) |
| | Ferp_0208 | PFAM: DNA primase small subunit; KEGG: afu:AF2298 hypothetical protein. (269 aa) |
| | Ferp_0225 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mja:MJ0089 ferric enterobactin transport ATP-binding protein. (266 aa) |
| | tfe | Transcription factor TFIIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongatio [...] (175 aa) |
| | dnaG | TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (393 aa) |
| | gatB | glutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (473 aa) |
| | rpl1 | Ribosomal protein L1; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (215 aa) |
| | csl4 | Exosome complex RNA-binding protein Csl4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (179 aa) |
| | rpoL | RNA polymerase dimerization; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (86 aa) |
| | Ferp_0272 | TIGRFAM: methylase; PFAM: methyltransferase small; KEGG: afu:AF1784 protoporphyrinogen oxidase (HemK). (192 aa) |
| | Ferp_0275 | PFAM: RNA polymerase Rpb4; KEGG: afu:AF1530 hypothetical protein. (118 aa) |
| | Ferp_0286 | PFAM: Protein of unknown function DUF509; KEGG: afu:AF0519 hypothetical protein. (155 aa) |
| | rnp3 | RNase P subunit p30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (190 aa) |
| | rnp2 | Ribonuclease P-related protein; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (112 aa) |
| | psmA | Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (241 aa) |
| | rrp4 | RNA binding S1 domain protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. (226 aa) |
| | rrp41 | Exosome complex exonuclease 1; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. (245 aa) |
| | rrp42 | 3' exoribonuclease; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. (259 aa) |
| | rpoP | RNA polymerase Rbp10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (47 aa) |
| | Ferp_0311 | KEGG: gme:Gmet_0329 nitrate reductase, alpha subunit; TIGRFAM: nitrate reductase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region. (1189 aa) |
| | Ferp_0312 | TIGRFAM: nitrate reductase, beta subunit; KEGG: gme:Gmet_0330 respiratory nitrate reductase beta subunit. (485 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: afu:AF1273 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (358 aa) |
| | top6B | DNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (592 aa) |
| | Ferp_0354 | PFAM: Like-Sm ribonucleoprotein core; SMART: Sm-family ribonucleoprotein; KEGG: afu:AF0362 snRNP, putative. (74 aa) |
| | Ferp_0363 | PFAM: heat shock protein Hsp20; KEGG: afu:AF1971 small heat shock protein (HSP20-2); Belongs to the small heat shock protein (HSP20) family. (137 aa) |
| | Ferp_0421 | Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (366 aa) |
| | Ferp_0438 | PFAM: protein of unknown function DUF86; KEGG: mja:MJ0434 hypothetical protein. (117 aa) |
| | Ferp_0468 | PFAM: type III restriction protein res subunit; SMART: DEAD-like helicase; KEGG: hwa:HQ2528A DNA repair helicase. (504 aa) |
| | tfb | Transcription factor TFIIB cyclin-related protein; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (346 aa) |
| | Ferp_0579 | KEGG: sto:ST0170 hypothetical protein. (200 aa) |
| | pan | 26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] (400 aa) |
| | rpl7ae | Ribosomal protein L7Ae/L30e/S12e/Gadd45; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (121 aa) |
| | Ferp_0687 | PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: afu:AF1285 cell division protein CDC48; Belongs to the AAA ATPase family. (352 aa) |
| | Ferp_0689 | PFAM: thiamineS protein; KEGG: tsi:TSIB_1624 hypothetical protein. (84 aa) |
| | Ferp_0703 | PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; KEGG: tsi:TSIB_0762 predicted metalloprotease. (130 aa) |
| | rps7 | Ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (194 aa) |
| | rps12 | Ribosomal protein S23 (S12); With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (142 aa) |
| | rpl30e | PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45; KEGG: afu:AF1890 50S ribosomal protein L30E (rpl30E); Belongs to the eukaryotic ribosomal protein eL30 family. (94 aa) |
| | rpoA2 | DNA-directed RNA polymerase, subunit A'; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (376 aa) |
| | Ferp_0761 | DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (870 aa) |
| | Ferp_0762 | DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (604 aa) |
| | Ferp_0763 | PFAM: RNA polymerase beta subunit; RNA polymerase Rpb2 domain 2; RNA polymerase Rpb2 domain 3; KEGG: afu:AF1886 DNA-directed RNA polymerase subunit beta''; Belongs to the RNA polymerase beta chain family. (491 aa) |
| | rpoH | RNA polymerase Rpb5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (76 aa) |
| | Ferp_0772 | KH domain protein; KEGG: afu:AF1805 putative RNA-processing protein; TIGRFAM: KH domain protein; PFAM: K Homology, type 1, subgroup; SMART: KH domain protein. (179 aa) |
| | ef1b | Translation elongation factor aEF-1 beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (88 aa) |
| | Ferp_0832 | Hydrogenase (NiFe) small subunit HydA; KEGG: afu:AF1381 F420-nonreducing hydrogenase (VhtG); TIGRFAM: hydrogenase (NiFe) small subunit HydA; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit. (350 aa) |
| | rpoD | RNA polymerase insert; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (262 aa) |
| | rps4 | Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (171 aa) |
| | Ferp_0864 | PFAM: ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; KEGG: mhu:Mhun_1298 ATPase. (1071 aa) |
| | Ferp_0865 | PFAM: 5-methylcytosine restriction system component-like protein; KEGG: mhu:Mhun_1299 McrBC 5-methylcytosine restriction system component-like. (426 aa) |
| | eif2a | Translation initiation factor 2, alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (265 aa) |
| | nop10 | RNA-binding protein Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (62 aa) |
| | nac | alpha-NAC related protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. (109 aa) |
| | Ferp_0903 | PFAM: tRNA methyltransferase complex GCD14 subunit; KEGG: afu:AF0216 L-isoaspartyl protein carboxyl methyltransferase PimT, putative. (246 aa) |
| | psmB | Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (210 aa) |
| | Ferp_0930 | PFAM: Beta propeller domain; KEGG: afu:AF0817 hypothetical protein. (616 aa) |
| | gatA | glutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (459 aa) |
| | Ferp_0962 | TIGRFAM: phosphate binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: afu:AF1356 phosphate ABC transporter, periplasmic phosphate-binding protein (PhoX). (317 aa) |
| | Ferp_0982 | PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: afu:AF2085 oxaloacetate decarboxylase, biotin carboxyl carrier subunit, putative. (140 aa) |
| | Ferp_0989 | TIGRFAM: addiction module toxin, RelE/StbE family; PFAM: plasmid stabilization system; KEGG: tko:TK0791 hypothetical protein. (88 aa) |
| | Ferp_1005 | PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; KEGG: dps:DP1769 formate dehydrogenase, selenocysteine-containing chain A. (954 aa) |
| | Ferp_1010 | PFAM: helix-turn-helix HxlR type; KEGG: ape:APE_2517.1 HxlR family transcriptional regulator. (101 aa) |
| | Ferp_1011 | PFAM: iron permease FTR1; KEGG: afu:AF0154 hypothetical protein. (281 aa) |
| | Ferp_1035 | PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; Enoyl-CoA hydratase/isomerase; KEGG: afu:AF0017 3-hydroxyacyl-CoA dehydrogenase (hbd-1); Belongs to the enoyl-CoA hydratase/isomerase family. (658 aa) |
| | Ferp_1072 | MCP methyltransferase, CheR-type; KEGG: afu:AF1037 chemotaxis protein methyltransferase (CheR); PFAM: MCP methyltransferase CheR-type; SMART: MCP methyltransferase CheR-type. (267 aa) |
| | Ferp_1084 | PFAM: PP-loop domain protein; KEGG: afu:AF1321 hypothetical protein. (290 aa) |
| | polB | DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (488 aa) |
| | rpl2 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (237 aa) |
| | rps19p | Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (133 aa) |
| | rpl22 | Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (153 aa) |
| | rps3 | Ribosomal protein S3; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (223 aa) |
| | rnp1 | Ribonuclease P, Rpp29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (91 aa) |
| | rpl24 | Ribosomal protein L24; Located at the polypeptide exit tunnel on the outside of the subunit. (120 aa) |
| | rps14 | Ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles. (51 aa) |
| | rpl19e | Ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (148 aa) |
| | rps5 | Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy. (196 aa) |
| | rpl30 | TIGRFAM: ribosomal protein L30P; PFAM: ribosomal protein L30; KEGG: afu:AF1904 50S ribosomal protein L30P. (152 aa) |
| | rpl15 | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (176 aa) |
| | pcn | Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (245 aa) |
| | priL | DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (383 aa) |
| | Ferp_1178 | PFAM: TIP49 domain protein; AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: afu:AF1813 TBP-interacting protein TIP49. (448 aa) |
| | Ferp_1179 | PFAM: GCN5-related N-acetyltransferase; KEGG: eba:ebA5292 transcriptional regulator. (154 aa) |
| | Ferp_1188 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; ferredoxin; KEGG: eba:ebA5294 hypothetical protein. (358 aa) |
| | Ferp_1229 | PFAM: Methyltransferase type 11; thiamineS protein; KEGG: hma:rrnB0259 cyclopropane-fatty-acyl-phospholipid synthase. (317 aa) |
| | Ferp_1234 | TIGRFAM: tRNA intron endonuclease; PFAM: tRNA intron endonuclease, catalytic domain protein; tRNA intron endonuclease domain protein; KEGG: afu:AF0900 tRNA splicing endonuclease. (294 aa) |
| | sucD | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa) |
| | Ferp_1246 | KEGG: afu:AF0684 succinate dehydrogenase, subunit D (SdhD). (115 aa) |
| | Ferp_1292 | PFAM: deoxyUTP pyrophosphatase; KEGG: afu:AF1108 deoxyuridine 5'-triphosphate nucleotidohydrolase. (166 aa) |
| | rtcB | PFAM: protein of unknown function UPF0027; KEGG: afu:AF0862 hypothetical protein; Belongs to the RtcB family. (480 aa) |
| | Ferp_1310 | PFAM: TIP49 domain protein; KEGG: hla:Hlac_2631 ORC1/cdc6 family replication initiation protein. (344 aa) |
| | cbiM | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (218 aa) |
| | Ferp_1347 | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: afu:AF0730 cobalt transport protein (CbiQ-1). (241 aa) |
| | rfcS | Replication factor C; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (321 aa) |
| | Ferp_1383 | Transcriptional regulator, ArsR family; PFAM: regulatory protein ArsR; KEGG: afu:AF2404 hypothetical protein. (87 aa) |
| | Ferp_1388 | PFAM: FAD linked oxidase domain protein; KEGG: rci:RCIX1754 (S)-2-hydroxy-acid dehydrogenase. (409 aa) |
| | tfb-2 | Transcription factor TFIIB cyclin-related protein; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (328 aa) |
| | Ferp_1390 | KEGG: afu:AF1298a hypothetical protein. (104 aa) |
| | Ferp_1413 | PFAM: MaoC domain protein dehydratase; KEGG: afu:AF1124 hypothetical protein. (149 aa) |
| | Ferp_1421 | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: afu:AF0871 glycerol-3-phosphate dehydrogenase (NAD(P)+) (GpsA); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (342 aa) |
| | Ferp_1424 | PFAM: MaoC domain protein dehydratase; KEGG: afu:AF1124 hypothetical protein. (153 aa) |
| | Ferp_1482 | KEGG: afu:AF0497 DNA polymerase B1 (PolB); TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B. (785 aa) |
| | Ferp_1483 | PFAM: histone deacetylase superfamily; KEGG: pth:PTH_0916 deacetylases. (240 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa) |
| | Ferp_1496 | PFAM: extracellular solute-binding protein family 5; KEGG: tsi:TSIB_1052 ABC-type dipeptide transport system, dipeptide binding protein. (533 aa) |
| | Ferp_1613 | KEGG: deb:DehaBAV1_0257 hydrogenase (NiFe) small subunit HydA; TIGRFAM: hydrogenase (NiFe) small subunit HydA; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit. (355 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (293 aa) |
| | srp54 | GTP-binding signal recognition particle SRP54 G- domain protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (431 aa) |
| | hjc | Resolvase, Holliday junction-type; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (132 aa) |
| | Ferp_1641 | SMART: Nucleotide binding protein PINc; KEGG: afu:AF0591 hypothetical protein. (138 aa) |
| | Ferp_1646 | Putative transcriptional regulator, ModE family; PFAM: regulatory protein LysR; KEGG: pmx:PERMA_1932 molybdenum-pterin-binding protein. (112 aa) |
| | Ferp_1670 | KEGG: afu:AF2198 hypothetical protein. (118 aa) |
| | Ferp_1721 | KEGG: afu:AF2049 hypothetical protein. (383 aa) |
| | Ferp_1749 | PFAM: Tetrahydromethanopterin S-methyltransferase MtrH subunit; KEGG: afu:AF0009 tetrahydromethanopterin S-methyltransferase subunit H. (316 aa) |
| | Ferp_1775 | Hypothetical protein; KEGG: mka:MK0125 Zn-ribbon containing protein. (91 aa) |
| | Ferp_1778 | PFAM: ABC-2 type transporter; KEGG: afu:AF1005 ABC transporter, ATP-binding protein, putative. (366 aa) |
| | priS | DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (355 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (461 aa) |
| | Ferp_1801 | TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; KEGG: afu:AF1365 hydrogenase expression/formation protein (HypE). (344 aa) |
| | Ferp_1802 | TIGRFAM: [NiFe] hydrogenase maturation protein HypF; PFAM: SUA5/yciO/yrdC domain; acylphosphatase; zinc finger HypF domain protein; KEGG: afu:AF1366 hydrogenase expression/formation regulatory protein (HypF). (745 aa) |
| | hypA | Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (115 aa) |
| | Ferp_1828 | PFAM: PP-loop domain protein; KEGG: afu:AF1595 hypothetical protein. (302 aa) |
| | Ferp_1829 | PFAM: RIO-like kinase; SMART: protein of unknown function RIO1; KEGG: afu:AF2426 hypothetical protein. (283 aa) |
| | Ferp_1833 | PFAM: carboxyl transferase; KEGG: afu:AF2217 methylmalonyl-CoA decarboxylase, subunit alpha (MmdA). (516 aa) |
| | Ferp_1835 | PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: afu:AF2216 methylmalonyl-CoA decarboxylase, biotin carboxyl carrier subunit (MmdC). (140 aa) |
| | Ferp_1842 | PFAM: Like-Sm ribonucleoprotein core; SMART: Sm-family ribonucleoprotein; KEGG: afu:AF0875 small nuclear ribonucleoprotein; Belongs to the snRNP Sm proteins family. (73 aa) |
| | Ferp_1859 | PFAM: protein of unknown function DUF86; KEGG: afu:AF2169 hypothetical protein. (137 aa) |
| | Ferp_1877 | KEGG: sae:NWMN_2258 teicoplanin resistance operon transcriptional regulator TcaR. (108 aa) |
| | Ferp_1889 | KEGG: afu:AF0385 hypothetical protein. (148 aa) |
| | Ferp_1912 | PFAM: GCN5-related N-acetyltransferase; KEGG: cbh:CLC_0962 acetyltransferase. (165 aa) |
| | Ferp_1948 | TIGRFAM: molybdenum cofactor synthesis domain protein; MoaD family protein; PFAM: MoeA domain protein domain I and II; thiamineS protein; molybdopterin binding domain; MoeA domain protein domain IV; KEGG: mac:MA4087 molybdenum cofactor biosynthesis protein MoeA2. (467 aa) |
| | rps2 | TIGRFAM: ribosomal protein S2; PFAM: ribosomal protein S2; KEGG: afu:AF1133 30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (204 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (402 aa) |
| | rpoK | RNA polymerase Rpb6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (73 aa) |
| | rpoN | RNA polymerase, N/8 Kd subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (72 aa) |
| | rpl13 | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (157 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa) |
| | Ferp_2086 | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: afu:AF1842 cobalt transport protein (CbiQ-2). (240 aa) |
| | rfcL | AAA ATPase central domain protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (506 aa) |
| | Ferp_2097 | KEGG: sto:ST0758 hypothetical protein. (114 aa) |
| | Ferp_2104 | TIGRFAM: MoaD family protein; PFAM: thiamineS protein; KEGG: mbu:Mbur_1415 molybdopterin converting factor small subunit MoaD. (91 aa) |
| | Ferp_2108 | Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. (316 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) |
| | Ferp_2138 | PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; KEGG: afu:AF2088 hypothetical protein. (256 aa) |
| | flpA | Fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (221 aa) |
| | Ferp_2150 | Hypothetical protein; KEGG: pmc:P9515_18871 polyphosphate kinase. (131 aa) |
| | Ferp_2163 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afu:AF1720 acetolactate synthase 3 catalytic subunit. (554 aa) |
| | Ferp_2192 | PFAM: restriction modification system DNA specificity domain; KEGG: pab:PAB2150 type I restriction-modification enzyme, S subunit. (421 aa) |
| | Ferp_2204 | KEGG: afu:AF1416 riboflavin synthase; TIGRFAM: riboflavin synthase; PFAM: 67-dimethyl-8-ribityllumazine synthase. (152 aa) |
| | Ferp_2212 | TIGRFAM: MoaD family protein; PFAM: thiamineS protein; KEGG: pmx:PERMA_0222 MoaD family protein. (89 aa) |
| | Ferp_2220 | PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; KEGG: afu:AF0164 ferredoxin-nitrite reductase (NirA). (459 aa) |
| | Ferp_2223 | Transcriptional regulator NikR, CopG family; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (136 aa) |
| | Ferp_2225 | KEGG: afu:AF1117 DNA-directed RNA polymerase subunit E'; TIGRFAM: DNA-directed RNA polymerase; PFAM: RNA polymerase Rpb7 domain protein; RNA binding S1 domain protein. (188 aa) |
| | spt4 | DNA-directed RNA polymerase subunit E, RpoE2; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (62 aa) |
| | kae1 | Metalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (322 aa) |
| | pfdB | Prefoldin, beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. (115 aa) |
| | Ferp_2267 | PFAM: Protein of unknown function DUF2144; KEGG: afu:AF1149a hypothetical protein. (74 aa) |
| | Ferp_2268 | Brix domain protein; Probably involved in the biogenesis of the ribosome. (162 aa) |
| | atpD | V-type ATPase, D subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (210 aa) |
| | atpB | ATP synthase, B subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (462 aa) |
| | atpA | ATP synthase, A subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (573 aa) |
| | atpC | ATP synthase A1, C subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (346 aa) |
| | atpE | H+transporting two-sector ATPase E subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (185 aa) |
| | Ferp_2308 | PFAM: H+transporting two-sector ATPase C subunit; KEGG: afu:AF1162 H+-transporting ATP synthase, subunit K (AtpK-2). (71 aa) |
| | Ferp_2309 | PFAM: V-type ATPase 116 kDa subunit; KEGG: afu:AF1159 V-type ATP synthase subunit I; Belongs to the V-ATPase 116 kDa subunit family. (647 aa) |
| | Ferp_2336 | TIGRFAM: MoaD family protein; PFAM: thiamineS protein; KEGG: pai:PAE2580 hypothetical protein. (98 aa) |
| | Ferp_2341 | KEGG: afu:AF1080 hypothetical protein. (85 aa) |
| | tatC-2 | Sec-independent protein translocase, TatC subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. (241 aa) |
| | Ferp_2360 | PFAM: Fibronectin-binding A domain protein; protein of unknown function DUF814; KEGG: afu:AF2038 hypothetical protein. (646 aa) |
| | Ferp_2408 | KEGG: tga:TGAM_1097 plasmid stabilization system addiction module toxin, RelE/StbE family. (38 aa) |
| | rps10 | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (106 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (142 aa) |
| | Ferp_2456 | PFAM: Protein of unknown function UPF0113; SMART: PUA domain containing protein; KEGG: afu:AF0058 hypothetical protein. (175 aa) |
| | Ferp_2462 | KEGG: rrs:RoseRS_2259 UvrD/REP helicase. (80 aa) |
| | Ferp_2476 | Translation initiation factor, aIF-2BII family; KEGG: afu:AF2037 translation initiation factor IF-2B subunit delta; TIGRFAM: translation initiation factor, aIF-2BII family; eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: initiation factor 2B related; Belongs to the eIF-2B alpha/beta/delta subunits family. (313 aa) |
| | Ferp_2524 | PFAM: plasmid stabilization system; KEGG: tga:TGAM_1097 plasmid stabilization system addiction module toxin, RelE/StbE family. (84 aa) |
| | srp19 | Ribonucleoprotein complex SRP, Srp19 component; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. (97 aa) |
| | Ferp_2567 | Protein of unknown function DUF101; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. (133 aa) |
