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speH speH Ferp_1828 Ferp_1828 Ferp_1816 Ferp_1816 Ferp_1775 Ferp_1775 Ferp_1759 Ferp_1759 Ferp_1756 Ferp_1756 Ferp_1739 Ferp_1739 Ferp_1722 Ferp_1722 Ferp_1668 Ferp_1668 Ferp_1660 Ferp_1660 Ferp_1646 Ferp_1646 Ferp_1571 Ferp_1571 Ferp_1553 Ferp_1553 purQ purQ leuD leuD Ferp_1424 Ferp_1424 Ferp_0689 Ferp_0689 thi4 thi4 rpl24e rpl24e aroA aroA Ferp_0491 Ferp_0491 Ferp_0384 Ferp_0384 guaAB guaAB Ferp_0332 Ferp_0332 purE purE rpl37ae rpl37ae rpl15e rpl15e rpl21e rpl21e Ferp_0135 Ferp_0135 pyrB pyrB Ferp_0047 Ferp_0047 Ferp_0034 Ferp_0034 rps19e rps19e rpl31e rpl31e rpl30e rpl30e nusA nusA Ferp_0752 Ferp_0752 leuC leuC Ferp_2513 Ferp_2513 Ferp_2508 Ferp_2508 Ferp_2507 Ferp_2507 rps3ae rps3ae leuC-2 leuC-2 Ferp_2460 Ferp_2460 Ferp_2401 Ferp_2401 Ferp_2391 Ferp_2391 Ferp_2350 Ferp_2350 Ferp_2336 Ferp_2336 guaAA guaAA Ferp_2248 Ferp_2248 Ferp_2235 Ferp_2235 purM purM rps24e rps24e Ferp_2219 Ferp_2219 Ferp_2215 Ferp_2215 Ferp_2212 Ferp_2212 Ferp_2210 Ferp_2210 Ferp_2198 Ferp_2198 Ferp_2142 Ferp_2142 leuD-2 leuD-2 Ferp_2104 Ferp_2104 Ferp_2073 Ferp_2073 Ferp_2031 Ferp_2031 Ferp_2030 Ferp_2030 Ferp_1982 Ferp_1982 eno eno Ferp_1948 Ferp_1948 Ferp_1901 Ferp_1901 aroA-2 aroA-2 Ferp_1413 Ferp_1413 spt5 spt5 Ferp_1333 Ferp_1333 Ferp_1311 Ferp_1311 Ferp_1304 Ferp_1304 Ferp_1292 Ferp_1292 Ferp_1284 Ferp_1284 rps17e rps17e Ferp_1277 Ferp_1277 Ferp_1229 Ferp_1229 rpl19e rpl19e rpl32e rpl32e rps19p rps19p Ferp_1122 Ferp_1122 Ferp_1121 Ferp_1121 Ferp_1089 Ferp_1089 Ferp_1084 Ferp_1084 cheB cheB Ferp_1072 Ferp_1072 Ferp_0995 Ferp_0995 Ferp_0917 Ferp_0917 Ferp_0885 Ferp_0885 Ferp_0814 Ferp_0814
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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speHS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (112 aa)
Ferp_1828PFAM: PP-loop domain protein; KEGG: afu:AF1595 hypothetical protein. (302 aa)
Ferp_1816PFAM: peptidase U62 modulator of DNA gyrase; KEGG: afu:AF0656 antibiotic maturation protein (PmbA). (400 aa)
Ferp_1775Hypothetical protein; KEGG: mka:MK0125 Zn-ribbon containing protein. (91 aa)
Ferp_1759PFAM: OsmC family protein; KEGG: cma:Cmaq_0586 OsmC family protein. (177 aa)
Ferp_1756PFAM: SirA family protein; KEGG: bcz:BCZK0674 hypothetical protein. (72 aa)
Ferp_1739KEGG: afu:AF2332 flavodoxin, putative. (148 aa)
Ferp_1722PFAM: protein of unknown function UPF0047; KEGG: mka:MK0814 hypothetical protein. (129 aa)
Ferp_1668PFAM: glutamine amidotransferase class-I; KEGG: afu:AF1277 hypothetical protein. (220 aa)
Ferp_1660KEGG: afu:AF0035 mannosephosphate isomerase, putative. (275 aa)
Ferp_1646Putative transcriptional regulator, ModE family; PFAM: regulatory protein LysR; KEGG: pmx:PERMA_1932 molybdenum-pterin-binding protein. (112 aa)
Ferp_1571PFAM: amidohydrolase 2; KEGG: pth:PTH_0014 metal-dependent hydrolase of the TIM-barrel fold. (265 aa)
Ferp_1553TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; KEGG: afu:AF2399 rRNA methylase, putative. (224 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (270 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa)
Ferp_1424PFAM: MaoC domain protein dehydratase; KEGG: afu:AF1124 hypothetical protein. (153 aa)
Ferp_0689PFAM: thiamineS protein; KEGG: tsi:TSIB_1624 hypothetical protein. (84 aa)
thi4Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (257 aa)
rpl24eRibosomal protein L24E; Binds to the 23S rRNA. (59 aa)
aroAPredicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (268 aa)
Ferp_0491Hypothetical protein; KEGG: rsq:Rsph17025_4391 smf family protein. (91 aa)
Ferp_0384PFAM: protein of unknown function DUF343; KEGG: mtp:Mthe_0864 hypothetical protein. (62 aa)
guaABGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (304 aa)
Ferp_0332TIGRFAM: alkylhydroperoxidase like protein, AhpD family; KEGG: afu:AF2408 hypothetical protein. (161 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (157 aa)
rpl37aeRibosomal protein L37a; Binds to the 23S rRNA. (86 aa)
rpl15ePFAM: Ribosomal protein L15e; KEGG: afu:AF2319 50S ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. (195 aa)
rpl21ePFAM: Ribosomal protein L21e; KEGG: afu:AF1529 50S ribosomal protein L21e; Belongs to the eukaryotic ribosomal protein eL21 family. (101 aa)
Ferp_0135SPP-like hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate. (219 aa)
pyrBKEGG: afu:AF0106 aspartate carbamoyltransferase, catalytic subunit (PyrB); TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region. (298 aa)
Ferp_0047PFAM: protein of unknown function DUF59; KEGG: dth:DICTH_0582 YitW. (90 aa)
Ferp_0034PFAM: protein of unknown function UPF0044; KEGG: afu:AF2070 hypothetical protein. (77 aa)
rps19eRibosomal protein S19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (149 aa)
rpl31ePFAM: Ribosomal protein L31e; KEGG: afu:AF2066 50S ribosomal protein L31E (rpl31E); Belongs to the ribosomal protein L31e family. (89 aa)
rpl30ePFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45; KEGG: afu:AF1890 50S ribosomal protein L30E (rpl30E); Belongs to the eukaryotic ribosomal protein eL30 family. (94 aa)
nusANusA family KH domain protein; Participates in transcription termination. Belongs to the NusA family. (139 aa)
Ferp_0752TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: MoeA domain protein domain I and II; molybdopterin binding domain; MoeA domain protein domain IV; KEGG: mfe:Mefer_1467 molybdenum cofactor synthesis domain protein. (534 aa)
leuCHomoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa)
Ferp_2513PFAM: Ferritin Dps family protein; KEGG: smr:Smar_0766 ferritin, Dps family protein. (138 aa)
Ferp_2508PFAM: protein of unknown function UPF0047; KEGG: afu:AF0741 hypothetical protein. (136 aa)
Ferp_2507PFAM: conserved hypothetical protein; KEGG: afu:AF1126 P450 cytochrome, putative. (149 aa)
rps3aePFAM: ribosomal protein S3Ae; KEGG: afu:AF2320 30S ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family. (211 aa)
leuC-2Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa)
Ferp_2460PFAM: SirA family protein; KEGG: hya:HY04AAS1_0598 SirA family protein. (78 aa)
Ferp_2401KEGG: afu:AF0323b dTDP-4-dehydrorhamnose 3,5-epimerase and related enzyme. (166 aa)
Ferp_2391TIGRFAM: glucose-1-phosphate thymidyltransferase; PFAM: Nucleotidyl transferase; transferase hexapeptide repeat containing protein; KEGG: tsi:TSIB_2044 glucose-1-phosphate thymidylyltransferase. (351 aa)
Ferp_2350PFAM: protein of unknown function DUF77; KEGG: afu:AF0571 hypothetical protein. (96 aa)
Ferp_2336TIGRFAM: MoaD family protein; PFAM: thiamineS protein; KEGG: pai:PAE2580 hypothetical protein. (98 aa)
guaAAGMP synthase, small subunit; Catalyzes the synthesis of GMP from XMP. (183 aa)
Ferp_2248KEGG: afu:AF0230 fructose-bisphosphate aldolase; TIGRFAM: predicted phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase. (261 aa)
Ferp_2235PFAM: Xylose isomerase domain protein TIM barrel; KEGG: afu:AF1279 hypothetical protein. (251 aa)
purMTIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; KEGG: afu:AF1693 phosphoribosylaminoimidazole synthetase. (323 aa)
rps24ePFAM: Ribosomal protein S24e; KEGG: afu:AF1114 SSU ribosomal protein S24E (rps24E); Belongs to the eukaryotic ribosomal protein eS24 family. (100 aa)
Ferp_2219PFAM: SirA family protein; KEGG: afu:AF0165 hypothetical protein. (80 aa)
Ferp_2215PFAM: SirA family protein; KEGG: mvu:Metvu_0623 SirA family protein. (71 aa)
Ferp_2212TIGRFAM: MoaD family protein; PFAM: thiamineS protein; KEGG: pmx:PERMA_0222 MoaD family protein. (89 aa)
Ferp_2210PFAM: SirA family protein; KEGG: afu:AF0554 hypothetical protein. (73 aa)
Ferp_2198PFAM: Orotidine 5'-phosphate decarboxylase; pyruvate carboxyltransferase; Dimethylmenaquinone methyltransferase; KEGG: afu:AF0861 bifunctional hexulose-6-phosphate synthase/ribonuclease regulator. (433 aa)
Ferp_2142PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: afu:AF2208 hydroxymethylpyrimidine phosphate kinase (ThiD). (251 aa)
leuD-23-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa)
Ferp_2104TIGRFAM: MoaD family protein; PFAM: thiamineS protein; KEGG: mbu:Mbur_1415 molybdopterin converting factor small subunit MoaD. (91 aa)
Ferp_2073PFAM: SMF family protein; KEGG: rsq:Rsph17025_4391 smf family protein. (246 aa)
Ferp_2031KEGG: afu:AF1098 fumarate hydratase; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region. (192 aa)
Ferp_2030TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region; KEGG: afu:AF1099 fumarate hydratase. (272 aa)
Ferp_1982PFAM: DRTGG domain protein; KEGG: afu:AF1212 hypothetical protein. (343 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (402 aa)
Ferp_1948TIGRFAM: molybdenum cofactor synthesis domain protein; MoaD family protein; PFAM: MoeA domain protein domain I and II; thiamineS protein; molybdopterin binding domain; MoeA domain protein domain IV; KEGG: mac:MA4087 molybdenum cofactor biosynthesis protein MoeA2. (467 aa)
Ferp_1901PFAM: DsrE family protein; KEGG: mma:MM_3292 hypothetical protein. (104 aa)
aroA-23-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (408 aa)
Ferp_1413PFAM: MaoC domain protein dehydratase; KEGG: afu:AF1124 hypothetical protein. (149 aa)
spt5NusG antitermination factor; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (151 aa)
Ferp_1333PFAM: amidohydrolase 2; KEGG: sat:SYN_01623 amidohydrolase. (226 aa)
Ferp_1311TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain; KEGG: afu:AF0265 molybdenum cofactor biosynthesis protein (MoaB). (167 aa)
Ferp_1304PFAM: protein of unknown function DUF98; KEGG: afu:AF1396 hypothetical protein. (166 aa)
Ferp_1292PFAM: deoxyUTP pyrophosphatase; KEGG: afu:AF1108 deoxyuridine 5'-triphosphate nucleotidohydrolase. (166 aa)
Ferp_1284PFAM: Xylose isomerase domain protein TIM barrel; KEGG: tga:TGAM_0740 deoxyribonuclease IV (BER) (Nfo). (250 aa)
rps17ePFAM: Ribosomal protein S17e; KEGG: afu:AF0911 SSU ribosomal protein S17E (rps17E); Belongs to the eukaryotic ribosomal protein eS17 family. (65 aa)
Ferp_1277Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (181 aa)
Ferp_1229PFAM: Methyltransferase type 11; thiamineS protein; KEGG: hma:rrnB0259 cyclopropane-fatty-acyl-phospholipid synthase. (317 aa)
rpl19eRibosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (148 aa)
rpl32ePFAM: Ribosomal protein L32e; KEGG: afu:AF1908 50S ribosomal protein L32e; Belongs to the eukaryotic ribosomal protein eL32 family. (135 aa)
rps19pRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (133 aa)
Ferp_1122Cysteine desulfurase; PFAM: aminotransferase class V; KEGG: afu:AF0186 NifS protein, class-V aminotransferase (NifS-1). (386 aa)
Ferp_1121PFAM: SirA family protein; KEGG: afu:AF0188 hypothetical protein. (72 aa)
Ferp_1089PFAM: SirA family protein; KEGG: bca:BCE_0868 hypothetical protein. (68 aa)
Ferp_1084PFAM: PP-loop domain protein; KEGG: afu:AF1321 hypothetical protein. (290 aa)
cheBResponse regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (348 aa)
Ferp_1072MCP methyltransferase, CheR-type; KEGG: afu:AF1037 chemotaxis protein methyltransferase (CheR); PFAM: MCP methyltransferase CheR-type; SMART: MCP methyltransferase CheR-type. (267 aa)
Ferp_0995Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (756 aa)
Ferp_0917PFAM: Uroporphyrinogen III synthase HEM4; KEGG: afu:AF0116 uroporphyrinogen III synthase (HemD). (228 aa)
Ferp_0885PFAM: Xylose isomerase domain protein TIM barrel; KEGG: afu:AF2428 hypothetical protein. (260 aa)
Ferp_0814TIGRFAM: RNA methyltransferase, TrmH family, group 1; PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: afu:AF1801 hypothetical protein. (230 aa)
Your Current Organism:
Ferroglobus placidus
NCBI taxonomy Id: 589924
Other names: F. placidus DSM 10642, Ferroglobus placidus AEDII12DO, Ferroglobus placidus DSM 10642, Ferroglobus placidus str. DSM 10642, Ferroglobus placidus strain DSM 10642
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