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| | cofG | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (320 aa) |
| | cofH | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (339 aa) |
| | Ferp_0085 | PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; KEGG: tpe:Tpen_0588 phosphoenolpyruvate synthase. (356 aa) |
| | Ferp_0086 | PFAM: PEP-utilising protein mobile region; KEGG: geo:Geob_0142 PEP-utilising protein mobile region. (617 aa) |
| | Ferp_0094 | PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; KEGG: pth:PTH_0579 anaerobic dehydrogenases. (680 aa) |
| | Ferp_0136 | PFAM: Tetrahydromethanopterin S-methyltransferase MtrH subunit; KEGG: afu:AF0009 tetrahydromethanopterin S-methyltransferase subunit H. (277 aa) |
| | Ferp_0139 | Methyl-viologen-reducing hydrogenase delta subunit; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (777 aa) |
| | Ferp_0140 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: afu:AF1644 tungsten formylmethanofuran dehydrogenase, subunit F (FwdF). (438 aa) |
| | apgM | Phosphonopyruvate decarboxylase-related protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (403 aa) |
| | mfnB | Protein of unknown function DUF556; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (234 aa) |
| | Ferp_0376 | TIGRFAM: 6-phospho 3-hexuloisomerase; PFAM: sugar isomerase (SIS); KEGG: afu:AF1796 hypothetical protein. (189 aa) |
| | Ferp_0598 | KEGG: afu:AF2138 phosphoserine phosphatase (SerB); TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein. (391 aa) |
| | aroA | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (268 aa) |
| | Ferp_0601 | PFAM: molydopterin dinucleotide-binding region; KEGG: afu:AF1928 tungsten formylmethanofuran dehydrogenase, subunit D (FwdD-2). (123 aa) |
| | Ferp_0602 | TIGRFAM: formylmethanofuran dehydrogenase subunit B; PFAM: molybdopterin oxidoreductase; KEGG: afu:AF1929 tungsten formylmethanofuran dehydrogenase, subunit B (FwdB-2). (415 aa) |
| | Ferp_0603 | TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase 3; KEGG: afu:AF1930 tungsten formylmethanofuran dehydrogenase, subunit A (FwdA). (560 aa) |
| | Ferp_0604 | KEGG: afu:AF1931 tungsten formylmethanofuran dehydrogenase, subunit C (FwdC); TIGRFAM: formylmethanofuran dehydrogenase subunit C; PFAM: glutamate synthase alpha subunit domain protein. (234 aa) |
| | mch | Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (315 aa) |
| | Ferp_0651 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: afu:AF0463m polyferredoxin (MvhB). (354 aa) |
| | Ferp_0657 | Formylmethanofuran--tetrahydromethanopterin N-formyltransferase; PFAM: formylmethanofuran: tetrahydromethanopterin formyltransferase (Ftr); KEGG: afu:AF2073 formylmethanofuran--tetrahydromethanopterin formyltransferase. (303 aa) |
| | Ferp_0728 | PFAM: Fe-S cluster domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: afu:AF1649 tungsten formylmethanofuran dehydrogenase, subunit G (FwdG). (156 aa) |
| | Ferp_0729 | TIGRFAM: formylmethanofuran dehydrogenase subunit B; KEGG: afu:AF1650 tungsten formylmethanofuran dehydrogenase, subunit B (FwdB-1). (402 aa) |
| | Ferp_0730 | KEGG: afu:AF1651 tungsten formylmethanofuran dehydrogenase, subunit D (FwdD-1). (131 aa) |
| | cdhA | CO dehydrogenase/acetyl-CoA synthase complex, epsilon subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (804 aa) |
| | cdhB | CO dehydrogenase/acetyl-CoA synthase complex, epsilon subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. Belongs to the CdhB family. (181 aa) |
| | cdhC | CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (525 aa) |
| | cdhD | CO dehydrogenase/acetyl-CoA synthase, delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family. (455 aa) |
| | cdhE | CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (471 aa) |
| | mer | 5,10-methylenetetrahydromethanopterin reductase; Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT; Belongs to the mer family. (332 aa) |
| | Ferp_0788 | PFAM: AMP-dependent synthetase and ligase; KEGG: chy:CHY_0659 acetyl-CoA synthetase. (634 aa) |
| | Ferp_0818 | PFAM: aspartate/glutamate/uridylate kinase; KEGG: afu:AF0572 hypothetical protein. (196 aa) |
| | Ferp_0819 | TIGRFAM: H4MPT-linked C1 transfer pathway protein; PFAM: Hydantoinase/oxoprolinase; KEGG: afu:AF0479 hypothetical protein. (310 aa) |
| | Ferp_0836 | Fumarate reductase/succinate dehydrogenase flavoprotein domain protein; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (660 aa) |
| | Ferp_0837 | KEGG: afu:AF1376 heterodisulfide reductase, subunit C (HdrC). (170 aa) |
| | Ferp_0838 | CoB--CoM heterodisulfide reductase; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: afu:AF1375 heterodisulfide reductase, subunit B (HdrB). (292 aa) |
| | Ferp_0839 | PFAM: methyl-viologen-reducing hydrogenase delta subunit; KEGG: afu:AF1374 methylviologen-reducing hydrogenase, subunit delta (VhuD). (137 aa) |
| | Ferp_0840 | PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; KEGG: afu:AF1373 methylviologen-reducing hydrogenase, subunit gamma (VhuG). (299 aa) |
| | Ferp_0841 | PFAM: nickel-dependent hydrogenase large subunit; KEGG: afu:AF1372 methylviologen-reducing hydrogenase, subunit alpha (VhuA). (457 aa) |
| | cofE | F420-dependent oxidoreductase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (248 aa) |
| | Ferp_0892 | TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: afu:AF1699 pyruvate ferredoxin oxidoreductase subunit gamma. (193 aa) |
| | Ferp_0893 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: afu:AF1700 pyruvate ferredoxin oxidoreductase, subunit delta (PorD). (97 aa) |
| | Ferp_0894 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; KEGG: afu:AF1701 pyruvate ferredoxin oxidoreductase, subunit alpha (PorA). (391 aa) |
| | Ferp_0895 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afu:AF1702 pyruvate ferredoxin oxidoreductase, subunit beta (PorB). (292 aa) |
| | Ferp_0929 | PFAM: CO dehydrogenase/acetyl-CoA synthase complex beta subunit; KEGG: mvu:Metvu_0967 CO dehydrogenase/acetyl-CoA synthase complex, beta subunit. (360 aa) |
| | Ferp_0942 | CoB--CoM heterodisulfide reductase; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: afu:AF0506 iron-sulfur binding reductase. (375 aa) |
| | cofD | LPPG domain protein containing protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (301 aa) |
| | Ferp_0997 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: rci:LRC441 sulfopyruvate decarboxylase, alpha chain. (360 aa) |
| | Ferp_1005 | PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; KEGG: dps:DP1769 formate dehydrogenase, selenocysteine-containing chain A. (954 aa) |
| | Ferp_1006 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: pna:Pnap_0835 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (187 aa) |
| | mtd | Methylenetetrahydromethanopterin dehydrogenase; Catalyzes the oxidation of methylene-H(4)MPT to methenyl- H(4)MPT(+). (272 aa) |
| | Ferp_1231 | 4Fe-4S ferredoxin iron-sulfur binding domain protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (159 aa) |
| | ftr | Formylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family. (297 aa) |
| | Ferp_1393 | CoB--CoM heterodisulfide reductase; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: mth:MTH1879 heterodisulfide reductase, subunit B. (267 aa) |
| | Ferp_1394 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mvu:Metvu_0281 CoB/CoM heterodisulfide reductase, subunit C. (163 aa) |
| | fbp | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (370 aa) |
| | Ferp_1614 | KEGG: dhd:Dhaf_3925 hypothetical protein. (218 aa) |
| | mfnA | Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (363 aa) |
| | Ferp_1666 | PFAM: glutamate synthase alpha subunit domain protein; KEGG: mth:MTH192 tungsten formylmethanofuran dehydrogenase, subunit C-like protein. (234 aa) |
| | Ferp_1667 | PFAM: glutamine amidotransferase class-II; KEGG: mth:MTH191 glutamine PRPP amidotransferase. (305 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (420 aa) |
| | Ferp_1735 | TIGRFAM: formaldehyde-activating enzyme; PFAM: Formaldehyde-activating enzyme (Fae); KEGG: afu:AF1305 bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase. (167 aa) |
| | Ferp_1746 | TIGRFAM: methyltransferase MtaA/CmuA family; PFAM: Uroporphyrinogen decarboxylase (URO-D); KEGG: mbu:Mbur_0808 methylcobalamin:coenzyme M methyltransferase. (341 aa) |
| | Ferp_1747 | PFAM: Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: cbb:CLD_3057 dimethylamine corrinoid protein. (231 aa) |
| | Ferp_1749 | PFAM: Tetrahydromethanopterin S-methyltransferase MtrH subunit; KEGG: afu:AF0009 tetrahydromethanopterin S-methyltransferase subunit H. (316 aa) |
| | Ferp_1761 | TIGRFAM: methyltransferase MtaA/CmuA family; PFAM: Uroporphyrinogen decarboxylase (URO-D); KEGG: mba:Mbar_A3639 methylcobalamin:coenzyme M methyltransferase. (355 aa) |
| | cofC | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (200 aa) |
| | Ferp_1823 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afu:AF2052 2-ketoisovalerate ferredoxin oxidoreductase, subunit beta (VorB). (278 aa) |
| | Ferp_1824 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: afu:AF2053 2-ketoisovalerate ferredoxin oxidoreductase, subunit alpha (VorA). (374 aa) |
| | Ferp_1825 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mvn:Mevan_0815 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit. (83 aa) |
| | Ferp_1826 | TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: afu:AF2055 2-ketoisovalerate ferredoxin oxidoreductase, subunit gamma (VorG). (164 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (402 aa) |
| | Ferp_2001 | PFAM: Lactate/malate dehydrogenase; KEGG: afu:AF0855 L-malate dehydrogenase, NAD+-dependent (MdhA); Belongs to the LDH/MDH superfamily. (295 aa) |
| | Ferp_2010 | Proposed homoserine kinase; KEGG: afu:AF1425 cofactor-independent phosphoglycerate mutase; TIGRFAM: proposed homoserine kinase; phosphonopyruvate decarboxylase-related protein; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein. (379 aa) |
| | ppcA | Phosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (476 aa) |
| | Ferp_2110 | TIGRFAM: phosphoenolpyruvate synthase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; PEP-utilizing protein; KEGG: afu:AF0710 phosphoenolpyruvate synthase. (753 aa) |
| | Ferp_2111 | KEGG: afu:AF0813 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (527 aa) |
| | fae-hps | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (394 aa) |
| | Ferp_2172 | TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: RimK domain protein ATP-grasp; KEGG: saz:Sama_1999 ribosomal protein S6 modification protein, putative. (297 aa) |
| | Ferp_2198 | PFAM: Orotidine 5'-phosphate decarboxylase; pyruvate carboxyltransferase; Dimethylmenaquinone methyltransferase; KEGG: afu:AF0861 bifunctional hexulose-6-phosphate synthase/ribonuclease regulator. (433 aa) |
| | Ferp_2248 | KEGG: afu:AF0230 fructose-bisphosphate aldolase; TIGRFAM: predicted phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase. (261 aa) |
| | Ferp_2285 | PFAM: protein of unknown function DUF201; KEGG: afu:AF1061 hypothetical protein. (305 aa) |
| | Ferp_2369 | KEGG: afu:AF1849 carbon monoxide dehydrogenase, catalytic subunit (CooS); TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane. (627 aa) |
| | Ferp_2562 | KEGG: sfu:Sfum_2875 carbon-monoxide dehydrogenase, catalytic subunit; TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane. (617 aa) |
| | Ferp_2563 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mhu:Mhun_1271 4Fe-4S ferredoxin, iron-sulfur binding. (196 aa) |
