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Ferp_0085 Ferp_0085 Ferp_0086 Ferp_0086 Ferp_0239 Ferp_0239 Ferp_0322 Ferp_0322 cdhD cdhD cdhE cdhE Ferp_0788 Ferp_0788 Ferp_0862 Ferp_0862 Ferp_0892 Ferp_0892 Ferp_0893 Ferp_0893 Ferp_0894 Ferp_0894 Ferp_0895 Ferp_0895 Ferp_0911 Ferp_0911 Ferp_0978 Ferp_0978 Ferp_1004 Ferp_1004 Ferp_1035 Ferp_1035 Ferp_1036 Ferp_1036 Ferp_1189 Ferp_1189 Ferp_1231 Ferp_1231 sucC sucC sucD sucD Ferp_1243 Ferp_1243 Ferp_1244 Ferp_1244 Ferp_1245 Ferp_1245 Ferp_1246 Ferp_1246 Ferp_1299 Ferp_1299 Ferp_1300 Ferp_1300 Ferp_1387 Ferp_1387 Ferp_1580 Ferp_1580 Ferp_1581 Ferp_1581 Ferp_1823 Ferp_1823 Ferp_1824 Ferp_1824 Ferp_1825 Ferp_1825 Ferp_1826 Ferp_1826 Ferp_1831 Ferp_1831 Ferp_1832 Ferp_1832 Ferp_1836 Ferp_1836 Ferp_1942 Ferp_1942 Ferp_1944 Ferp_1944 Ferp_2001 Ferp_2001 Ferp_2030 Ferp_2030 Ferp_2031 Ferp_2031 ppcA ppcA Ferp_2110 Ferp_2110 Ferp_2323 Ferp_2323 Ferp_2330 Ferp_2330 Ferp_2331 Ferp_2331 Ferp_2369 Ferp_2369 Ferp_2450 Ferp_2450 Ferp_2554 Ferp_2554 Ferp_2555 Ferp_2555 Ferp_2562 Ferp_2562 Ferp_2563 Ferp_2563
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ferp_0085PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; KEGG: tpe:Tpen_0588 phosphoenolpyruvate synthase. (356 aa)
Ferp_0086PFAM: PEP-utilising protein mobile region; KEGG: geo:Geob_0142 PEP-utilising protein mobile region. (617 aa)
Ferp_0239TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; KEGG: afu:AF1252m oxaloacetate decarboxylase. (480 aa)
Ferp_0322TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: afu:AF0220 pyruvate carboxylase subunit A. (514 aa)
cdhDCO dehydrogenase/acetyl-CoA synthase, delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family. (455 aa)
cdhECO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (471 aa)
Ferp_0788PFAM: AMP-dependent synthetase and ligase; KEGG: chy:CHY_0659 acetyl-CoA synthetase. (634 aa)
Ferp_0862KEGG: afu:AF0647 isocitrate dehydrogenase, NADP (icd); TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase. (412 aa)
Ferp_0892TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: afu:AF1699 pyruvate ferredoxin oxidoreductase subunit gamma. (193 aa)
Ferp_0893TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: afu:AF1700 pyruvate ferredoxin oxidoreductase, subunit delta (PorD). (97 aa)
Ferp_0894PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; KEGG: afu:AF1701 pyruvate ferredoxin oxidoreductase, subunit alpha (PorA). (391 aa)
Ferp_0895PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afu:AF1702 pyruvate ferredoxin oxidoreductase, subunit beta (PorB). (292 aa)
Ferp_0911Vinylacetyl-CoA Delta-isomerase; PFAM: 4-hydroxyphenylacetate 3-hydroxylase; KEGG: afu:AF0885 4-hydroxyphenylacetate-3-hydroxylase (HpaA-2). (456 aa)
Ferp_0978KEGG: afu:AF2416 acetyl-CoA acetyltransferase. (382 aa)
Ferp_1004TIGRFAM: acetyl-CoA acetyltransferase; KEGG: cbf:CLI_3339 acetyl-CoA acetyltransferase. (393 aa)
Ferp_1035PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; Enoyl-CoA hydratase/isomerase; KEGG: afu:AF0017 3-hydroxyacyl-CoA dehydrogenase (hbd-1); Belongs to the enoyl-CoA hydratase/isomerase family. (658 aa)
Ferp_1036Propanoyl-CoA C-acyltransferase; KEGG: afu:AF0018 3-ketoacyl-CoA thiolase (AcaB-1). (400 aa)
Ferp_1189Propanoyl-CoA C-acyltransferase; KEGG: afu:AF0438 acetyl-CoA acetyltransferase. (388 aa)
Ferp_12314Fe-4S ferredoxin iron-sulfur binding domain protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (159 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (381 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
Ferp_1243TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: afu:AF0681 succinate dehydrogenase flavoprotein subunit. (567 aa)
Ferp_1244KEGG: afu:AF0682 succinate dehydrogenase iron-sulfur subunit; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein. (236 aa)
Ferp_1245KEGG: afu:AF0683 succinate dehydrogenase, subunit C (SdhC). (122 aa)
Ferp_1246KEGG: afu:AF0684 succinate dehydrogenase, subunit D (SdhD). (115 aa)
Ferp_1299PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; KEGG: afu:AF0749 2-oxoacid ferredoxin oxidoreductase, subunit alpha (orA). (528 aa)
Ferp_1300PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afu:AF0750 2-oxoacid ferredoxin oxidoreductase, subunit beta (orB). (249 aa)
Ferp_1387CoB--CoM heterodisulfide reductase; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: mbu:Mbur_1774 hypothetical protein. (353 aa)
Ferp_1580methylmalonyl-CoA mutase, large subunit; KEGG: afu:AF1288a methylmalonyl-CoA mutase N-terminal domain-containing protein; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase. (568 aa)
Ferp_1581PFAM: cobalamin B12-binding domain protein; KEGG: afu:AF1288b methylmalonyl-CoA mutase C-terminal domain-containing protein. (141 aa)
Ferp_1823PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afu:AF2052 2-ketoisovalerate ferredoxin oxidoreductase, subunit beta (VorB). (278 aa)
Ferp_1824PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: afu:AF2053 2-ketoisovalerate ferredoxin oxidoreductase, subunit alpha (VorA). (374 aa)
Ferp_1825TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mvn:Mevan_0815 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit. (83 aa)
Ferp_1826TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: afu:AF2055 2-ketoisovalerate ferredoxin oxidoreductase, subunit gamma (VorG). (164 aa)
Ferp_1831PFAM: cobalamin B12-binding domain protein; KEGG: afu:AF2219 methylmalonyl-CoA mutase, subunit alpha, C-terminus (mcmA2). (141 aa)
Ferp_1832TIGRFAM: methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: afu:AF2218 hypothetical protein. (131 aa)
Ferp_1836KEGG: afu:AF2215 methylmalonyl-CoA mutase, subunit alpha, N-terminus (mcmA1); TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase. (548 aa)
Ferp_1942PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; Enoyl-CoA hydratase/isomerase; KEGG: afu:AF0285 3-hydroxyacyl-CoA dehydrogenase (hbd-2); Belongs to the enoyl-CoA hydratase/isomerase family. (652 aa)
Ferp_1944Propanoyl-CoA C-acyltransferase; PFAM: Beta-ketoacyl synthase; KEGG: afu:AF0283 acetyl-CoA acetyltransferase. (392 aa)
Ferp_2001PFAM: Lactate/malate dehydrogenase; KEGG: afu:AF0855 L-malate dehydrogenase, NAD+-dependent (MdhA); Belongs to the LDH/MDH superfamily. (295 aa)
Ferp_2030TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region; KEGG: afu:AF1099 fumarate hydratase. (272 aa)
Ferp_2031KEGG: afu:AF1098 fumarate hydratase; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region. (192 aa)
ppcAPhosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (476 aa)
Ferp_2110TIGRFAM: phosphoenolpyruvate synthase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; PEP-utilizing protein; KEGG: afu:AF0710 phosphoenolpyruvate synthase. (753 aa)
Ferp_2323Propanoyl-CoA C-acyltransferase; KEGG: mth:MTH793 acetyl-CoA acetyltransferase. (388 aa)
Ferp_2330PFAM: cobalamin B12-binding domain protein; KEGG: afu:AF2219 methylmalonyl-CoA mutase, subunit alpha, C-terminus (mcmA2). (138 aa)
Ferp_2331KEGG: eba:ebA2060 methylmalonyl-CoA mutase subunit alpha; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase. (539 aa)
Ferp_2369KEGG: afu:AF1849 carbon monoxide dehydrogenase, catalytic subunit (CooS); TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane. (627 aa)
Ferp_2450TIGRFAM: acetyl-CoA acetyltransferase; KEGG: afu:AF1197 3-ketoacyl-CoA thiolase (FadA-2). (425 aa)
Ferp_2554KEGG: afu:AF0967 acetyl-CoA acetyltransferase. (400 aa)
Ferp_2555KEGG: afu:AF0968 acetyl-CoA acetyltransferase. (380 aa)
Ferp_2562KEGG: sfu:Sfum_2875 carbon-monoxide dehydrogenase, catalytic subunit; TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit; PFAM: Prismane. (617 aa)
Ferp_2563PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mhu:Mhun_1271 4Fe-4S ferredoxin, iron-sulfur binding. (196 aa)
Your Current Organism:
Ferroglobus placidus
NCBI taxonomy Id: 589924
Other names: F. placidus DSM 10642, Ferroglobus placidus AEDII12DO, Ferroglobus placidus DSM 10642, Ferroglobus placidus str. DSM 10642, Ferroglobus placidus strain DSM 10642
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