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| | aroK | Shikimate kinase; KEGG: afu:AF0520 hypothetical protein; TIGRFAM: shikimate kinase; PFAM: GHMP kinase. (273 aa) |
| | Ferp_0062 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: afu:AF0935 homoserine dehydrogenase. (330 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa) |
| | apgM | Phosphonopyruvate decarboxylase-related protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (403 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (220 aa) |
| | argG | KEGG: afu:AF2252 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (395 aa) |
| | Ferp_0239 | TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; KEGG: afu:AF1252m oxaloacetate decarboxylase. (480 aa) |
| | Ferp_0322 | TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: afu:AF0220 pyruvate carboxylase subunit A. (514 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa) |
| | Ferp_0374 | TIGRFAM: hisA/hisF family protein; PFAM: histidine biosynthesis protein; KEGG: afu:AF0713 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (HisA-1); Belongs to the HisA/HisF family. (223 aa) |
| | Ferp_0376 | TIGRFAM: 6-phospho 3-hexuloisomerase; PFAM: sugar isomerase (SIS); KEGG: afu:AF1796 hypothetical protein. (189 aa) |
| | Ferp_0381 | TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: afu:AF0080 acetylornithine aminotransferase (ArgD-1); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (378 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa) |
| | Ferp_0597 | PFAM: peptidase dimerisation domain protein; peptidase M20; KEGG: afu:AF0522 acetylornithine deacetylase. (322 aa) |
| | Ferp_0598 | KEGG: afu:AF2138 phosphoserine phosphatase (SerB); TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; amino acid-binding ACT domain protein. (391 aa) |
| | aroA | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (268 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (280 aa) |
| | Ferp_0682 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: afu:AF0051 succinyl-diaminopimelate desuccinylase (DapE-1). (379 aa) |
| | leuC | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa) |
| | Ferp_0724 | KEGG: afu:AF1255 ornithine carbamoyltransferase; TIGRFAM: ornithine carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (305 aa) |
| | Ferp_0737 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (388 aa) |
| | Ferp_0744 | KEGG: pmx:PERMA_0022 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (460 aa) |
| | Ferp_0804 | KEGG: afu:AF0700 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (463 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa) |
| | Ferp_0809 | TIGRFAM: LL-diaminopimelate aminotransferase; PFAM: aminotransferase class I and II; KEGG: afu:AF0409 LL-diaminopimelate aminotransferase. (384 aa) |
| | Ferp_0810 | KEGG: afu:AF1340 citrate synthase (CitZ); TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase. (375 aa) |
| | Ferp_0862 | KEGG: afu:AF0647 isocitrate dehydrogenase, NADP (icd); TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase. (412 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: afu:AF0883 argininosuccinate lyase (ArgH). (481 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (267 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (333 aa) |
| | mat | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (399 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afu:AF0986 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (HisA-2). (237 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: afu:AF0985 imidazoleglycerol-phosphate dehydrogenase/histidinol-phosphatase (HisB). (186 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: afu:AF1146 3-phosphoglycerate kinase (pgk); Belongs to the phosphoglycerate kinase family. (405 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa) |
| | Ferp_1199 | PFAM: aminotransferase class I and II; KEGG: afu:AF2366 aspartate aminotransferase (AspB-1). (377 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (288 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase, type II; KEGG: afu:AF1732 glyceraldehyde-3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain. (335 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (430 aa) |
| | cimA | Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (489 aa) |
| | Ferp_1446 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: afu:AF0904 diaminopimelate aminotransferase. (399 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (271 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (389 aa) |
| | fbp | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (370 aa) |
| | ilvD | KEGG: afu:AF1014 dihydroxy-acid dehydratase (IlvD); TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (546 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: afu:AF2002 histidinol-phosphate aminotransferase (HisC-1). (344 aa) |
| | Ferp_1664 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: afu:AF0949 glutamine synthetase (GlnA). (480 aa) |
| | hisC-2 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: afu:AF2024 histidinol-phosphate aminotransferase (HisC-2). (344 aa) |
| | Ferp_1730 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: afu:AF2112 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (317 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (420 aa) |
| | Ferp_1871 | PFAM: NADP oxidoreductase coenzyme F420-dependent; KEGG: tga:TGAM_1616 pyrroline-5-carboxylate reductase (ProC). (231 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (408 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (402 aa) |
| | Ferp_1994 | PFAM: Indole-3-glycerol phosphate synthase; KEGG: mae:Maeo_1115 indole-3-glycerol-phosphate synthase. (224 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (324 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (433 aa) |
| | Ferp_1997 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: mvn:Mevan_0330 anthranilate synthase component II. (186 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: pab:PAB2047 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (207 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (385 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (251 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (274 aa) |
| | Ferp_2010 | Proposed homoserine kinase; KEGG: afu:AF1425 cofactor-independent phosphoglycerate mutase; TIGRFAM: proposed homoserine kinase; phosphonopyruvate decarboxylase-related protein; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein. (379 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (253 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (281 aa) |
| | Ferp_2111 | KEGG: afu:AF0813 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (527 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) |
| | Ferp_2126 | KEGG: afu:AF0628 multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (325 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (222 aa) |
| | fae-hps | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (394 aa) |
| | Ferp_2162 | TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; KEGG: afu:AF1719 acetolactate synthase 3 regulatory subunit. (161 aa) |
| | Ferp_2163 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afu:AF1720 acetolactate synthase 3 catalytic subunit. (554 aa) |
| | Ferp_2198 | PFAM: Orotidine 5'-phosphate decarboxylase; pyruvate carboxyltransferase; Dimethylmenaquinone methyltransferase; KEGG: afu:AF0861 bifunctional hexulose-6-phosphate synthase/ribonuclease regulator. (433 aa) |
| | Ferp_2213 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: afu:AF0551 threonine synthase. (404 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (290 aa) |
| | Ferp_2248 | KEGG: afu:AF0230 fructose-bisphosphate aldolase; TIGRFAM: predicted phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase. (261 aa) |
| | aroD | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (204 aa) |
| | Ferp_2251 | PFAM: prephenate dehydratase; Chorismate mutase, type II; Prephenate dehydrogenase; amino acid-binding ACT domain protein; KEGG: afu:AF0227 chorismate mutase/prephenate dehydratase (PheA). (637 aa) |
| | Ferp_2288 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: afu:AF0219 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (499 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (377 aa) |
| | Ferp_2446 | PFAM: aminotransferase class I and II; KEGG: afu:AF2129 aspartate aminotransferase. (375 aa) |
| | Ferp_2451 | PFAM: asparagine synthase; KEGG: afu:AF1439 asparagine synthetase (AsnB). (385 aa) |
| | leuC-2 | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa) |
| | Ferp_2510 | KEGG: afu:AF0589 ribose-phosphate pyrophosphokinase (PrsA-1); TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family. (277 aa) |
| | hisE | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: hut:Huta_1413 phosphoribosyl-ATP diphosphatase. (92 aa) |
