STRINGSTRING
ACZ75065.1 ACZ75065.1 ACZ75066.1 ACZ75066.1 murB murB ACZ75162.1 ACZ75162.1 ACZ75163.1 ACZ75163.1 ACZ75164.1 ACZ75164.1 ACZ75165.1 ACZ75165.1 ACZ75166.1 ACZ75166.1 murA murA ACZ75793.1 ACZ75793.1 rlpA rlpA mrdB mrdB mrdA mrdA ftsI ftsI mltG mltG ACZ76459.1 ACZ76459.1 ACZ76758.1 ACZ76758.1 minE minE ACZ76844.1 ACZ76844.1 minC minC ACZ77084.1 ACZ77084.1 mltF mltF ACZ77969.1 ACZ77969.1 ACZ77995.1 ACZ77995.1 ftsB ftsB ftsZ ftsZ ftsA ftsA ftsQ ftsQ ACZ78360.1 ACZ78360.1 murC murC murG murG ftsW ftsW murD murD mraY mraY murF murF murE murE ftsI-2 ftsI-2 ftsL ftsL rsmH rsmH mraZ mraZ mpl mpl ACZ78476.1 ACZ78476.1 ACZ78637.1 ACZ78637.1 glpG glpG ACZ78867.1 ACZ78867.1 ftsE ftsE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACZ75065.1PFAM: protein of unknown function DUF610 YibQ; KEGG: dze:Dd1591_3943 protein of unknown function DUF610 YibQ. (309 aa)
ACZ75066.1PFAM: Peptidase M23; KEGG: dze:Dd1591_3942 peptidase M23. (424 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (345 aa)
ACZ75162.1TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl; KEGG: dze:Dd1591_3835 cell shape determining protein, MreB/Mrl family. (347 aa)
ACZ75163.1TIGRFAM: rod shape-determining protein MreC; PFAM: Rod shape-determining protein MreC; KEGG: dze:Dd1591_3834 rod shape-determining protein MreC. (376 aa)
ACZ75164.1Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. (162 aa)
ACZ75165.1Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (197 aa)
ACZ75166.1KEGG: dze:Dd1591_3831 ribonuclease, Rne/Rng family; TIGRFAM: ribonuclease, Rne/Rng family; PFAM: RNA-binding protein AU-1/Ribonuclease E/G; RNA binding S1 domain protein. (489 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa)
ACZ75793.1KEGG: dze:Dd1591_3188 N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; SMART: cell wall hydrolase/autolysin. (412 aa)
rlpARare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (382 aa)
mrdBRod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa)
mrdAPenicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (636 aa)
ftsIPeptidoglycan glycosyltransferase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (566 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (344 aa)
ACZ76459.1TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease; KEGG: dze:Dd1591_1630 hydrolase, TatD family. (264 aa)
ACZ76758.1TIGRFAM: lytic murein transglycosylase; PFAM: Peptidoglycan-binding domain 1 protein; KEGG: dze:Dd1591_1902 lytic murein transglycosylase. (440 aa)
minECell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (96 aa)
ACZ76844.1TIGRFAM: septum site-determining protein MinD; PFAM: Cobyrinic acid ac-diamide synthase; KEGG: dze:Dd1591_1996 septum site-determining protein MinD. (270 aa)
minCSeptum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (232 aa)
ACZ77084.1KEGG: ana:alr1779 hypothetical protein. (340 aa)
mltFLytic transglycosylase catalytic; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (485 aa)
ACZ77969.1Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (847 aa)
ACZ77995.1PFAM: Lytic transglycosylase catalytic; MLTD_N domain protein; Peptidoglycan-binding lysin domain; SMART: Peptidoglycan-binding LysM; KEGG: dze:Dd1591_1006 lytic transglycosylase catalytic. (465 aa)
ftsBSeptum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (117 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (418 aa)
ftsQCell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (284 aa)
ACZ78360.1KEGG: dze:Dd1591_0612 hypothetical protein. (51 aa)
murCUDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (486 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (363 aa)
ftsWCell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (400 aa)
murDUDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (437 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (453 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (494 aa)
ftsI-2Peptidoglycan glycosyltransferase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (587 aa)
ftsLCell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (107 aa)
rsmHS-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (313 aa)
mraZMraZ protein; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster. (152 aa)
mplUDP-N-acetylmuramate; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (460 aa)
ACZ78476.1PFAM: cell wall hydrolase/autolysin; Peptidoglycan-binding lysin domain; SMART: cell wall hydrolase/autolysin; Peptidoglycan-binding LysM; KEGG: dze:Dd1591_0489 cell wall hydrolase/autolysin. (563 aa)
ACZ78637.1TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; KEGG: dze:Dd1591_0253 penicillin-binding protein, 1A family. (852 aa)
glpGRhomboid protease; Rhomboid-type serine protease that catalyzes intramembrane proteolysis. (274 aa)
ACZ78867.1Protein insertion ABC transporter, inner membrane subunit FtsX; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (325 aa)
ftsEType II (General) Secretory Pathway (IISP) Family protein; Part of the ABC transporter FtsEX involved in cellular division. (222 aa)
Your Current Organism:
Dickeya zeae
NCBI taxonomy Id: 590409
Other names: D. zeae Ech586, Dickeya dadantii Ech586, Dickeya zeae Ech586
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