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pyrG pyrG murE murE murF murF murD murD murC murC gshA gshA panC panC purL purL guaA guaA purK purK ACZ77610.1 ACZ77610.1 ACZ77430.1 ACZ77430.1 ACZ77427.1 ACZ77427.1 ACZ77425.1 ACZ77425.1 bioD-2 bioD-2 rimK rimK bioD bioD nadE nadE pncB pncB lplA lplA ACZ76414.1 ACZ76414.1 ACZ76040.1 ACZ76040.1 purC purC purM purM argG argG ACZ74952.1 ACZ74952.1 tilS tilS ddl ddl ACZ75379.1 ACZ75379.1 ACZ75266.1 ACZ75266.1 ACZ75155.1 ACZ75155.1 ACZ75141.1 ACZ75141.1 purD purD birA birA queC queC ACZ75046.1 ACZ75046.1 ACZ78950.1 ACZ78950.1 epmA epmA purA purA mpl mpl gshB gshB carA carA carB carB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (494 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (453 aa)
murDUDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (437 aa)
murCUDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (486 aa)
gshAKEGG: dze:Dd1591_0987 glutamate/cysteine ligase; TIGRFAM: glutamate/cysteine ligase; PFAM: glutamate--cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (516 aa)
panCPantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (525 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (356 aa)
ACZ77610.1FolC bifunctional protein; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. (422 aa)
ACZ77430.1PFAM: IucA/IucC family protein; KEGG: dze:Dd1591_2677 IucA/IucC family protein. (629 aa)
ACZ77427.1PFAM: IucA/IucC family protein; KEGG: dze:Dd1591_2674 IucA/IucC family protein. (618 aa)
ACZ77425.1PFAM: IucA/IucC family protein; KEGG: dze:Dd1591_2672 IucA/IucC family protein. (630 aa)
bioD-2Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (226 aa)
rimKTIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: RimK domain protein ATP-grasp; KEGG: dze:Dd1591_2388 alpha-L-glutamate ligase, RimK family; Belongs to the RimK family. (300 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (223 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (274 aa)
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (401 aa)
lplALipoyltransferase and lipoate-protein ligase; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Belongs to the LplA family. (338 aa)
ACZ76414.1KEGG: dze:Dd1591_1584 putative carbamoyl-phosphate-synthetase protein. (393 aa)
ACZ76040.1KEGG: dze:Dd1591_2945 asparagine synthase (glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. (554 aa)
purCKEGG: dze:Dd1591_2982 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (237 aa)
purMKEGG: dze:Dd1591_2992 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (345 aa)
argGKEGG: dze:Dd1591_0068 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (449 aa)
ACZ74952.1KEGG: dze:Dd1591_0045 UreA carboxylase; TIGRFAM: urea carboxylase; urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; Allophanate hydrolase subunit 1; biotin/lipoyl attachment domain-containing protein; SMART: Allophanate hydrolase subunit 2; Allophanate hydrolase subunit 1. (1197 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (448 aa)
ddlD-alanine/D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (366 aa)
ACZ75379.1TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: dze:Dd1591_3591 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (204 aa)
ACZ75266.1PFAM: protein of unknown function DUF404; protein of unknown function DUF407; KEGG: dda:Dd703_3574 protein of unknown function DUF404. (481 aa)
ACZ75155.1acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
ACZ75141.1CTP synthase; PFAM: glutamine amidotransferase class-I; KEGG: dda:Dd703_3700 CTP synthase. (230 aa)
purDKEGG: dze:Dd1591_3862 phosphoribosylamine/glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (429 aa)
birAbiotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (319 aa)
queCexsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa)
ACZ75046.1Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (418 aa)
ACZ78950.1TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: dze:Dd1591_4156 glutamine synthetase, type I. (469 aa)
epmAlysyl-tRNA synthetase-related protein GenX; With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P; Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily. (325 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
mplUDP-N-acetylmuramate; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (460 aa)
gshBKEGG: dze:Dd1591_0502 glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: glutathione synthetase ATP-binding; glutathione synthetase domain protein; Belongs to the prokaryotic GSH synthase family. (317 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: dze:Dd1591_0554 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (381 aa)
carBTIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; KEGG: dze:Dd1591_0555 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1074 aa)
Your Current Organism:
Dickeya zeae
NCBI taxonomy Id: 590409
Other names: D. zeae Ech586, Dickeya dadantii Ech586, Dickeya zeae Ech586
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