STRINGSTRING
ACZ74919.1 ACZ74919.1 ACZ75010.1 ACZ75010.1 ACZ75070.1 ACZ75070.1 metE metE ACZ75236.1 ACZ75236.1 ACZ75279.1 ACZ75279.1 acdS acdS mdh mdh ACZ75695.1 ACZ75695.1 ACZ75705.1 ACZ75705.1 ACZ75796.1 ACZ75796.1 ACZ75866.1 ACZ75866.1 ACZ75878.1 ACZ75878.1 ACZ75924.1 ACZ75924.1 ACZ76493.1 ACZ76493.1 ACZ76587.1 ACZ76587.1 ACZ76671.1 ACZ76671.1 ACZ76701.1 ACZ76701.1 ACZ76726.1 ACZ76726.1 ACZ76730.1 ACZ76730.1 ACZ76731.1 ACZ76731.1 ACZ76833.1 ACZ76833.1 serC serC ACZ77808.1 ACZ77808.1 ACZ77850.1 ACZ77850.1 ACZ77896.1 ACZ77896.1 ACZ77953.1 ACZ77953.1 mtnN mtnN speE speE speD speD luxS luxS gshA gshA mtnK mtnK mtnA mtnA mtnD mtnD mtnC mtnC mtnB mtnB ACZ78271.1 ACZ78271.1 ACZ78433.1 ACZ78433.1 ACZ78446.1 ACZ78446.1 metK metK gshB gshB ACZ78517.1 ACZ78517.1 ACZ78520.1 ACZ78520.1 metAS metAS asd asd ilvE ilvE ACZ78762.1 ACZ78762.1 ACZ78763.1 ACZ78763.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ACZ74919.1Aminotransferase class V; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (373 aa)
ACZ75010.1Acyl-homoserine-lactone synthase; PFAM: autoinducer synthesis protein; KEGG: dze:Dd1591_0101 acyl-homoserine-lactone synthase. (212 aa)
ACZ75070.1KEGG: dze:Dd1591_3938 serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: serine acetyltransferase domain protein; transferase hexapeptide repeat containing protein. (273 aa)
metE5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (755 aa)
ACZ75236.1TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: dze:Dd1591_3762 cystathionine beta-lyase. (397 aa)
ACZ75279.1PFAM: alpha/beta hydrolase fold; KEGG: dze:Dd1591_3724 alpha/beta hydrolase fold protein; Belongs to the AB hydrolase superfamily. MetX family. (355 aa)
acdS1-aminocyclopropane-1-carboxylate deaminase; Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. (338 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. (313 aa)
ACZ75695.1TIGRFAM: cysteine synthase B; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: dze:Dd1591_3277 cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (293 aa)
ACZ75705.1TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: dze:Dd1591_3268 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
ACZ75796.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: dze:Dd1591_3184 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding. (337 aa)
ACZ75866.1PFAM: Methionine synthase vitamin-B12 independent; KEGG: dze:Dd1591_3115 methionine synthase vitamin-B12 independent. (366 aa)
ACZ75878.1PFAM: Methionine synthase vitamin-B12 independent; KEGG: dze:Dd1591_3103 methionine synthase vitamin-B12 independent. (371 aa)
ACZ75924.1PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: dze:Dd1591_3061 pyridoxal-5'-phosphate-dependent protein beta subunit. (350 aa)
ACZ76493.1Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: dze:Dd1591_1664 aspartate transaminase. (396 aa)
ACZ76587.1PFAM: amidohydrolase; KEGG: kpe:KPK_B0072 amidohydrolase family protein. (465 aa)
ACZ76671.1PFAM: GAF domain protein; SMART: GAF domain protein; KEGG: dze:Dd1591_1843 putative GAF sensor protein. (171 aa)
ACZ76701.1PFAM: Methionine synthase vitamin-B12 independent; KEGG: dda:Dd703_1778 methionine synthase vitamin-B12 independent. (343 aa)
ACZ76726.1PFAM: aminotransferase class IV; KEGG: pct:PC1_2699 aminotransferase class IV. (311 aa)
ACZ76730.1Cystathionine gamma-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: spe:Spro_1626 cystathionine gamma-synthase. (384 aa)
ACZ76731.1PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; SMART: CBS domain containing protein; KEGG: spe:Spro_1627 pyridoxal-5'-phosphate-dependent protein beta subunit. (455 aa)
ACZ76833.1KEGG: dze:Dd1591_1985 L-serine dehydratase 1; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (453 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
ACZ77808.1KEGG: dze:Dd1591_1241 L-serine dehydratase 1; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa)
ACZ77850.1PFAM: aminotransferase class I and II; KEGG: ajs:Ajs_1376 aminotransferase, class I and II. (393 aa)
ACZ77896.1PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein; KEGG: dze:Dd1591_1113 rhodanese domain protein. (284 aa)
ACZ77953.1KEGG: dze:Dd1591_1056 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (422 aa)
mtnNMTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...] (233 aa)
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (287 aa)
speDS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (264 aa)
luxSQuorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
gshAKEGG: dze:Dd1591_0987 glutamate/cysteine ligase; TIGRFAM: glutamate/cysteine ligase; PFAM: glutamate--cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (516 aa)
mtnK5-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (400 aa)
mtnATranslation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (343 aa)
mtnDAcireductone dioxygenase ARD; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (180 aa)
mtnC2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (236 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (204 aa)
ACZ78271.1PFAM: aminotransferase class I and II; KEGG: dze:Dd1591_0702 aminotransferase class I and II. (397 aa)
ACZ78433.1KEGG: dze:Dd1591_0533 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family. (818 aa)
ACZ78446.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; KEGG: dze:Dd1591_0520 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding. (410 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
gshBKEGG: dze:Dd1591_0502 glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: glutathione synthetase ATP-binding; glutathione synthetase domain protein; Belongs to the prokaryotic GSH synthase family. (317 aa)
ACZ78517.1KEGG: dze:Dd1591_0372 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (454 aa)
ACZ78520.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa)
metASHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (366 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa)
ACZ78762.1KEGG: dze:Dd1591_0121 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; aspartate/glutamate/uridylate kinase; homoserine dehydrogenase NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family. (811 aa)
ACZ78763.1KEGG: dze:Dd1591_0120 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (386 aa)
Your Current Organism:
Dickeya zeae
NCBI taxonomy Id: 590409
Other names: D. zeae Ech586, Dickeya dadantii Ech586, Dickeya zeae Ech586
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